A5074552841- Inflammatory Bowel Disease
- COVID-19 Clinical Research Studies
- Gene expression and cancer classification
- Long-Term Effects of COVID-19
- Nuclear Receptors and Signaling
- Single-cell and spatial transcriptomics
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Genomics and Phylogenetic Studies
- Hematological disorders and diagnostics
- Microscopic Colitis
- Mitochondrial Function and Pathology
- Bioinformatics and Genomic Networks
- Immune responses and vaccinations
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammation biomarkers and pathways
- Molecular Biology Techniques and Applications
- Cholesterol and Lipid Metabolism
- Cancer-related molecular mechanisms research
- Veterinary medicine and infectious diseases
University of Oslo
2022-2024
Oslo University Hospital
2023-2024
Abstract A maladaptive inflammatory response has been implicated in the pathogenesis of severe COVID-19. This study aimed to characterize temporal dynamics this and investigate whether disease is associated with distinct gene expression patterns. We performed microarray analysis serial whole blood RNA samples from 17 patients COVID-19, 15 moderate 11 healthy controls. All subjects were unvaccinated. assessed patterns by differential analysis, set enrichment, two clustering methods estimated...
Improved transcriptomic sequencing technologies now make it possible to perform longitudinal experiments, thus generating a large amount of data. Currently, there are no dedicated or comprehensive methods for the analysis these experiments. In this article, we describe our TimeSeries Analysis pipeline (TiSA) which combines differential gene expression, clustering based on recursive thresholding, and functional enrichment analysis. Differential expression is performed both temporal...
There is accumulating evidence that interfering with the basic aging mechanisms can enhance healthy longevity. The interventional/therapeutic strategies targeting multiple hallmarks could be more effective than one hallmark. While health-promoting qualities of marine oils have been extensively studied, underlying molecular are not fully understood. Lipid extracts from Antarctic krill rich in long-chain omega-3 fatty acids choline, and astaxanthin. Here, we used C. elegans human cells to...
ABSTRACT Nth-like DNA glycosylase (NTHL1) is a base excision repair enzyme, with crucial role both in nuclear and mitochondrial genomic maintenance. In this study, we demonstrate key function of NTHL1 on (mtDNA) maintenance dynamics. Our results reveal significant accumulation transcripts increased mtDNA levels NTHL1-deficient cells, accompanied by an lesions. These findings underscore the essential protecting against damage. addition to OXPHOS mRNA protein levels, Seahorse analyzer...
Many high-throughput sequencing datasets can be represented as objects with coordinates along a reference genome. Currently, biological investigations often involve large number of such datasets, for example representing different cell types or epigenetic factors. Drawing overall conclusions from collection results individual may challenging and time-consuming. Meaningful interpretation requires the to aggregated according metadata that represents characteristics interest. In this light, we...
Abstract Background One of the main drivers colitis associated colorectal cancer (CA-CRC) is suspected to be long-standing mucosal inflammation, but far from all patients develop cancer. We analyzed gene expression profiles in ulcerative (UC) who have progressed neoplasia (progressors) compared those not (non-progressors) order identify underlying mechanisms for neoplastic progression UC patients. Methods performed transcriptome profiling on 143 samples non-neoplastic colon segments 14...