A5077923665- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Cystic Fibrosis Research Advances
- DNA Repair Mechanisms
- Chronic Lymphocytic Leukemia Research
- Integrated Water Resources Management
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
Children's Memorial Health Institute
2013-2020
Instytut Matki i Dziecka
2013
Common variable immune deficiency (CVID) is a heterogeneous disease associated with ineffective production of antibodies. It usually diagnosed in adulthood, but proportion children develop CVID. Early identification patients potentially worse prognosis may help to avoid serious complications. The goal this study was associate the clinical phenotype early onset CVID peripheral B-cell maturation profile. Four color flow cytometry used define distribution subsets 49 early-onset All data were...
Primary immunodeficiencies (PIDs) are rare disorders of the immune system encompassing inborn errors immunity. antibody deficiencies constitute largest group PID with common variable immunodeficiency (CVID) being most symptomatic form. Combined (CID) accompanied by deficiency can mimic CVID and these patients need verification final diagnosis. Respiratory involvement, especially interstitial lung disease (ILD), poses a relevant cause morbidity mortality among in some cases is first...
Abstract Background: Defects in early B lymphocyte maturation bone marrow (BM) compose a characteristic feature of many primary immune deficiencies associated with agammaglobulinemia. To date, only limited data on the composition precursor B‐cell compartment BM is available. The aim this study was to define normal age‐related ranges total content and distribution B—cell stages for future use clinical diagnostics. Methods: Four color flow cytometry used analyze specimens from 59...
Patients with Nijmegen Breakage Syndrome (NBS) suffer from recurrent infections due to humoral and cellular immune deficiency. Despite low number of T lymphocytes their maturation defect, the clinical manifestations cell-mediated deficiency are not as severe in case patients other types combined deficiencies similar cell lymphopenia. In this study, multicolor flow cytometry was used for evaluation peripheral lymphocyte according currently known differentiation pathway, 46 genetically...