A5023761751- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Blood properties and coagulation
- Platelet Disorders and Treatments
- Extracellular vesicles in disease
- Caveolin-1 and cellular processes
- Blood disorders and treatments
- Congenital heart defects research
- Antiplatelet Therapy and Cardiovascular Diseases
Framingham Heart Study
2023
National Heart Lung and Blood Institute
2023
The Francis Crick Institute
2023
University of Massachusetts Lowell
2023
Platelet activation causes the release of extracellular vesicles, which a small proportion contain respiratory competent mitochondria. Mitochondria are integral for energy production and in regulation apoptotic pathways. However, existence mitochondria highlights potential new role intercellular communication. We hypothesised that platelet vesicles containing could be taken up by circulatory cells alter their function. In this work we demonstrate interact with internalised neutrophils. Flow...
Decreased left ventricle (LV) function caused by genetic mutations or injury often leads to debilitating and fatal cardiovascular disease. LV cardiomyocytes are, therefore, a potentially valuable therapeutical target. Human pluripotent stem cell-derived (hPSC-CMs) are neither homogeneous nor functionally mature, which reduces their utility. Here, we exploit cardiac development knowledge instruct differentiation of hPSCs specifically toward cardiomyocytes. Correct mesoderm patterning retinoic...