A5048625554- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Nausea and vomiting management
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
- Treatment of Major Depression
- Electroconvulsive Therapy Studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Hemodynamic Monitoring and Therapy
- Intraoperative Neuromonitoring and Anesthetic Effects
- Trauma and Emergency Care Studies
- Hip and Femur Fractures
- Aortic aneurysm repair treatments
- Anesthesia and Neurotoxicity Research
- Dental Anxiety and Anesthesia Techniques
- Acute Myocardial Infarction Research
- Enhanced Recovery After Surgery
- Pain Management and Opioid Use
- Airway Management and Intubation Techniques
- Vascular anomalies and interventions
- Optical Imaging and Spectroscopy Techniques
- Urinary Tract Infections Management
Medical University of Vienna
2010-2023
Universitätsklinikum Tulln
2023
University of Chicago
2018-2019
American Society of Anesthesiologists
2018
Committee on Publication Ethics
2018
Washington University in St. Louis
2013-2017
Leiden University Medical Center
2017
Taylor Family Institute for Innovative Psychiatric Research
2017
Hennepin County Medical Center
2016
University of Minnesota
2016
N-methyl-D-aspartate receptor antagonists, such as ketamine, have rapid antidepressant effects in patients with treatment-resistant depression (TRD). We hypothesized that nitrous oxide, an inhalational general anesthetic and antagonist, may also be a rapidly acting treatment for TRD.In this blinded, placebo-controlled crossover trial, 20 TRD were randomly assigned to 1-hour inhalation of 50% oxide/50% oxygen or nitrogen/50% (placebo control). The primary endpoint was the change on 21-item...
BACKGROUND: This study sought to determine whether preoperatively measured high-sensitivity cardiac troponin T (hs-cTnT) and N -terminal pro-brain natriuretic peptide (NT-proBNP) improve risk prediction in patients undergoing major noncardiac surgery compared with the standard indices. METHODS: In this ancillary Vitamins Nitrous Oxide trial, were included who had preoperative hs-cTnT NT-proBNP (n = 572). Study outcome was incidence of postoperative myocardial infarction (MI) within first 3...
Esketamine is traditionally administered via intravenous or intramuscular routes. In this study we developed a pharmacokinetic model of inhalation nebulized esketamine with special emphasis on pulmonary absorption and bioavailability.Three increasing doses inhaled (dose escalation from 25 to 100 mg) were applied followed by single dose (20 in 19 healthy volunteers using nebulizer system arterial concentrations esnorketamine obtained. A multicompartmental was population nonlinear...
In Brief Levobupivacaine is the isolated S(−)-stereoisomer of racemic bupivacaine. Important pharmacodynamic properties levobupivacaine have not been determined for femoral three-in-one block. this randomized, controlled, double-blinded trial, we studied 60 ASA physical status I–III patients scheduled surgery lower limb. A nerve-stimulator-guided block was performed as supplemental analgesic therapy with 20 mL bupivacaine 0.5% (n = 20), or 0.25% 20). Sensory onset time, quality blockade, and...
The diagnosis of myocardial infarction (MI) after noncardiac surgery has traditionally relied on using relatively insensitive contemporary cardiac troponin (cTn) assays. We hypothesized that a recently introduced novel high-sensitivity cTnT (hscTnT) assay would increase the detection rate perioperative MI.In this ancillary study Vitamins in Nitrous Oxide trial, readjudicated incidence rates injury (new isolated cTn elevation) and MI were compared when diagnosed by cTnI versus hscTnT. probed...
Two-rescuer cardiopulmonary resuscitation (CPR) is considered the best method for professional basic life support (BLS). However, in many prehospital cardiac arrest situations, one rescuer has to begin CPR alone while other performs additional tasks. In theory, over-the-head a suitable alternative this situation, with added benefit of allowing single use self-inflating bag ventilation. trial, we compared standard single-rescuer manikins. We planned study using crossover design where each...
Early diagnosis of acute compartment syndrome (ACS) the leg is essential to improve outcome. Direct invasive measurement currently recommended measure intracompartmental pressure. A non-invasive and reproducible means making would be a step forward. The purpose this exploratory study was investigate feasibility ultrasound-guided angle as surrogate increased pressure in model ACS.A ACS generated by infusion saline into anterior human cadavers incrementally increase from 10 100 mmHg. In 40...
WE report a case of bite damage to wire-reinforced endotracheal tube caused by transcranial electrical stimulation (TES).A 23-yr-old female patient (American Society Anesthesiologists grade I) with mild motor deficits in the lower extremities was admitted for extirpation an intramedullary cervical spinal cord tumor (C3–C7).Intraoperative neurophysiological monitoring using motor-evoked potentials (MEPs) elicited TES and somatosensory-evoked performed assess functional integrity cord.1After...
While electroconvulsive therapy is widely regarded as a lifesaving and safe procedure, evidence regarding its effects on myocardial cell injury sparse. The objective of this investigation was to determine the incidence magnitude new cardiac troponin elevation after using novel high-sensitivity I assay.
Prolongation of the QTc interval indicates abnormal cardiac repolarization. A recent study has shown that postoperative prolongation is common. However, it unknown whether an isolated phenomenon or occurs regularly during surgery, type anesthesia influences its incidence.To answer this question, we conducted a prospective cohort (n = 300), where duration was continuously recorded by 12-lead Holter electrocardiogram from 30 minutes preoperatively to up 60 postoperatively. compared between...
In Brief BACKGROUND: Prolonged administration of nitrous oxide causes an increase in plasma homocysteine children via vitamin B12 inactivation. However, it is unclear whether doses used clinical practice cause adverse hematological effects pediatric patients. METHODS: This retrospective study included 54 patients undergoing elective spinal surgery: 41 received throughout anesthesia (maintenance group), 9 for induction and/or emergence (induction/emergence and 4 did not receive (nitrous...
Knowledge about longitudinal changes in epidemiological data at mass gathering events is sparse. The goal of this study was to determine and compare the type, severity frequency illnesses a large music festival over 7 consecutive years (2011-2017).Prospectively collected from rescue operation protocols an Austrian were retrieved analyzed. Patient presentation rates (PPR) transport hospital (TTHR) calculated compared between years. Linear regression used investigate association (a) total...
Many patients experience moderate to severe postoperative pain. Nitrous oxide (N₂O) exerts analgesia by inhibition of N-methyl-D-aspartate receptors. Ketamine, another receptor antagonist, reduces opioid consumption and A similar effect N₂O is plausible, yet understudied. The goal this study was determine the effects anesthesia on early postsurgical pain.This a retrospective, secondary analysis Vitamins In Oxide trial, where 500 undergoing general for noncardiac surgery received 60% 125 no...
The use of certain peripheral nerve blocks in paediatric patients is gaining increasing popularity, although distinctive characteristics the juvenile anatomy, psychological barriers, time constraints on block placement, and risks neurotoxic cardio toxic side effects are still mentioned. However, newer agents like Ropivacaine Levobupivacaine seem to offer excellent alternatives Bupivacaine Lidocaine, especially for patients.We evaluated 0.5% Lidocaine 1.0% using axillary plexus blockade as a...