A5057677030- Viral Infectious Diseases and Gene Expression in Insects
- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Amphibian and Reptile Biology
- Healthcare and Venom Research
- Transgenic Plants and Applications
- Spectroscopy and Chemometric Analyses
- Protein purification and stability
- thermodynamics and calorimetric analyses
- Toxin Mechanisms and Immunotoxins
- Bacillus and Francisella bacterial research
- Advanced Control Systems Optimization
- Biomedical and Engineering Education
- Antimicrobial Peptides and Activities
- Spectroscopy Techniques in Biomedical and Chemical Research
- Virology and Viral Diseases
- Virus-based gene therapy research
- Poxvirus research and outbreaks
- Membrane Separation Technologies
- Bee Products Chemical Analysis
- Organ Transplantation Techniques and Outcomes
- Beetle Biology and Toxicology Studies
- 3D Printing in Biomedical Research
- Clostridium difficile and Clostridium perfringens research
- Diphtheria, Corynebacterium, and Tetanus
Medecell (Brazil)
2024
Universidade Estadual Paulista (Unesp)
2024
Instituto Butantan
1995-2019
Universidade de São Paulo
2013-2019
Fundação Oswaldo Cruz
2019
Victims of massive bee attacks become extremely ill, presenting symptoms ranging from dizziness and headache to acute renal failure multiple organ that can lead death. Previous attempts develop specific antivenom treat these victims have been unsuccessful. We herein report a F(ab)´2-based raised in horse as potential new treatment for stings. The final product contains high IgG titers is effective neutralizing toxic effects, such hemolysis, cytotoxicity myotoxicity. assessment neutralization...
Background Snake envenoming is a significant public health problem in underdeveloped and developing countries. In sub-Saharan Africa, it estimated that 90,000–400,000 envenomations occur each year, resulting 3,500–32,000 deaths. Envenomings are caused by snakes from the Viperidae (Bitis spp. Echis spp.) Elapidae (Naja Dendroaspis families. The African continent has been suffering severe antivenom crisis current production only sufficient to treat 25% of snakebite cases. Our aim develop...
Viral safety remains a challenge when processing plasma-derived product. A variety of pathogens might be present in the starting material, which requires downstream process capable broad viral reduction. In this article, we used wide panel viruses to assess removal/inactivation our for Snake Antivenom Immunoglobulin (SAI). First, screened and excluded equine plasma that cross-reacted with any model virus, procedure not published before antivenoms. addition, evaluated first time virucidal...
Monitoring mammalian cell culture with UV–vis spectroscopy has not been widely explored. The aim of this work was to calibrate Partial Least Squares (PLS) models from off-line spectral data in order predict some nutrients and metabolites, as well viable concentrations for bioprocess using phenol red medium. BHK-21 line used a model. Spectra samples taken batches performed at different dissolved oxygen (10, 30, 50, 70% air saturation), two bioreactor configurations strategies control pH were...
Baby Hamster Kidney cells (BHK-21) are commonly used in research and the biopharmaceutical industry. This work aimed to model kinetic performance batch operation mode of BHK-21 cultured two stirred tank configurations using different dissolved oxygen concentrations pH control strategies. Viable dead cell concentrations, as well glucose, glutamine, lactate ammonium were monitored. Statistical multiple linear regression, logistic equation multiplicative Monod models fitted. for viable...
This work aimed to compare the predictive capacity of empirical models, based on uniform design utilization combined artificial neural networks with respect classical factorial designs in bioprocess, using as example rabies virus replication BHK-21 cells. The viral infection process parameters under study were temperature (34°C, 37°C), multiplicity (0.04, 0.07, 0.1), times infection, and harvest (24, 48, 72 hours) monitored output parameter was production. A multilevel experimental performed...
<sec> <title>BACKGROUND</title> Background: Translational science is the process of applying basic scientific knowledge with goal developing clinical research by creating new medicines, devices, medical procedures, preventative measures, and diagnostic kits. These actions are known as moving “from bench to bedside.” The Covid-19 pandemic has highlighted a shortage translational professionals prepared respond immediately global demands. To achieve these advancements, investigators must...
Os colaboradores nao fazem parte da Fiocruz, entretanto submeteram o trabalho ao evento organizado e disponibilizado por Bio-Manguinhos cedendo assim os direitos a unidade.