A5083973635- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
University of Cambridge
2016-2024
Wellcome/MRC Cambridge Stem Cell Institute
2016
Medical Research Council
2016
Posttranscriptional modifications in transfer RNA (tRNA) are often critical for normal development because they adapt protein synthesis rates to a dynamically changing microenvironment. However, the precise cellular mechanisms linking extrinsic stimulus intrinsic modification pathways remain largely unclear. Here, we identified cytosine-5 methyltransferase NSUN2 as sensor external stress stimuli. Exposure oxidative efficiently repressed NSUN2, causing reduction of methylation at specific...