A5071267798- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Liver Disease and Transplantation
- Viral-associated cancers and disorders
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Oral and Maxillofacial Pathology
- Genetic factors in colorectal cancer
- Agriculture and Rural Development Research
- Cardiac, Anesthesia and Surgical Outcomes
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
Shizuoka Cancer Center
2016-2025
Nagoya University
1994-2025
Kasugai Municipal Hospital
2018-2019
University Medical Center Utrecht
2013
Toyohashi Municipal Hospital
2009-2012
Institute of Agrobiological Sciences
1986
Duke University
1973
Duke University Hospital
1973
Duke Medical Center
1973
Cornell University
1973
Abstract In pancreatic cancer (PC), Tumor mutation burden (TMB) has been reported to be lower than in other cancers, with its clinical significance remaining unclear. We analyzed the dataset of whole-exome sequencing and gene expression profiling 93 resected PC cases. The median TMB was 0.24. classified as High (≥ 5.0), Low (< 5.0, ≥ 1.0), or Ultra-low 1.0). Nineteen samples (20%) were TMB-low, 74 (80%) TMB-ultra-low; no TMB-high. TMB-ultra-low had significantly fewer borderline...
Hepatectomy is the primary treatment for malignant liver tumours. It crucial to control bleeding during parenchymal transection. Methods reduce central venous pressure (CVP), such as fluid restriction and use of vasodilators, are essential minimising but can lead haemodynamic instability. Phosphodiesterase-3 (PDEIII) inhibitors milrinone have shown efficacy in managing low CVP maintaining stability. This study investigates olprinone, another PDEIII inhibitor with a potentially strong...
Pembrolizumab has been introduced to solid cancers with microsatellite instability (MSI)-high cases; however, its clinical experience for cholangiocarcinoma remains very limited. Here, we present a case who successfully underwent conversion surgery following pembrolizumab treatment MSI-high perihilar cholangiocarcinoma, which pathologically exhibited complete response. A 69-year-old male Bismuth IV bulky lymphadenopathy was referred, initially required left hepatic trisectionectomy, caudate...
Objective: This study aimed to evaluate the nature of perioperative dysgeusia and its associated factors in patients undergoing pancreatoduodenectomy (PD). Background: Perioperative is an unfavorable symptom with malnutrition. Methods: The Taste Alteration Survey Trace Elements PD (TASTE-PD) was a single-center prospective observational performed between April 2021 September 2022. Dysgeusia evaluated using questionnaire administered 100 during hospitalization. A blood examination also for...
The prognostic value of the perioperative carbohydrate antigen 19-9 (CA19-9) and relationship between CA19-9 surgical margin in extrahepatic cholangiocarcinoma (EHCC) have not been fully discussed.
Background: The classification of intrahepatic cholangiocarcinomas (ICCs) has been reported in several studies, however, it remains controversial. Materials and Methods: Between January 2003 December 2015, 94 patients underwent hepatectomy for ICC. ICCs 63 these were classified as predominantly small bile duct type or ductular ICC included this analysis. Results: Thirty-seven (58.7%) into the group, 26 (41.3%) group. A multivariate analysis identified metastasis [hazard ratio (HR)=2.53,...
There are a few reports that compare the rate of postoperative complications between subtotal stomach-preserving pancreatoduodenectomy (SSPPD) and antrectomy-combined (ACPD), especially with respect to delayed gastric emptying (DGE) after (PD).From 2002 2013, 628 patients who underwent SSPPD (n = 78) or ACPD 550) were enrolled in this study. The DGE nutritional status compared receiving SSPPD.The overall morbidity (p 0.830) was comparable both groups; however, incidence grade B C...