A5047658599- Animal Behavior and Reproduction
- T-cell and B-cell Immunology
- Evolution and Genetic Dynamics
- Immune Cell Function and Interaction
- Plant and animal studies
- SARS-CoV-2 and COVID-19 Research
- Immune responses and vaccinations
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- MicroRNA in disease regulation
- vaccines and immunoinformatics approaches
- interferon and immune responses
- Physiological and biochemical adaptations
- Advanced biosensing and bioanalysis techniques
- Insect-Plant Interactions and Control
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Chromosomal and Genetic Variations
- Wildlife Ecology and Conservation
- Aquaculture disease management and microbiota
- Amphibian and Reptile Biology
- Immune Response and Inflammation
Jagiellonian University
2016-2024
Abstract Variation in the vertebrate major histocompatibility complex (MHC) genes is crucial for fighting pathogen assault. Because new alleles confer a selective advantage, MHC should readily introgress between species, even under limited hybridization. Using replicated transects through two hybrid zones strongly reproductively isolated European newts, Lissotriton montandoni and L. vulgaris , we demonstrated recent ongoing class I II introgression Carpathian region. The extent of correlated...
Abstract Major histocompatibility complex (MHC) genes are crucial for the adaptive immune response of jawed vertebrates. Their variation, reaching extreme levels, is driven mainly by an arms race between hosts and pathogens. One hypothesised mechanism contributing to MHC polymorphism introgression, exchange genetic variants hybridising species favoured selection, yet its effect on variation poorly understood. Detection though challenging, may be facilitated analysis complexes forming...
Abstract The Major Histocompatibility Complex (MHC) genes encode proteins that initiate the adaptive immune response by presenting pathogen‐derived antigenic peptides to T lymphocytes. Host–pathogen coevolution drives MHC polymorphism, introducing intraspecific variation in host life expectancy. This interacts with optimal growth strategy, as increases reproductive potential. While mortality rate and body size‐dependent fecundity are major factors shaping histories, effect of MHC‐based...
The major histocompatibility complex (MHC) genes are central to the adaptive immune response in vertebrates. Selection generally maintains high MHC variation because spectrum of recognized pathogens depends on polymorphism. Novel alleles favoured by selection originate interallelic recombination or de novo mutations but may also be acquired introgression from related species. However, extent and prevalence remain an open question. In this study, we tested for six hybrid zones formed Triturus...
Abstract Interspecific introgression is a potentially important source of novel variation adaptive significance. Although multiple cases are well documented, broader generalizations about its targets and mechanisms lacking. Multiallelic balancing selection, particularly when acting through rare allele advantage, an evolutionary mechanism expected to favor introgression. This because introgressed alleles likely confer immediate selective facilitating their establishment in the recipient...
Selection acting on males can reduce mutation load of sexual relative to asexual populations, thus mitigating the twofold cost sex, provided that it seeks and destroys same mutations as selection females, but with higher efficiency. This could happen due selection—a potent evolutionary force in most systems predominantly affects males. We used replicate populations red flour beetles (Tribolium castaneum) study sex‐specific against deleterious introduced ionizing radiation. found no evidence...
Abstract Sexual selection may increase population‐level fitness by facilitating the removal of deleterious mutations with pleiotropic effects on competition for fertilizations as well other components in both sexes. Under inbreeding, this could promote purging selection, that is recessive alleles exposed homozygotes via matings between closely related individuals. Here, two independent experiments, we found no evidence short‐term inbreeding load from severely bottlenecked populations red...
According to theory, sexual selection in males may efficiently purge mutation load of populations, reducing or fully compensating 'the cost males'. For this occur, mutations not only need be deleterious both sexes, they also must affect more than females. A frequently overlooked problem is that relative strength on versus females vary between environments, with social conditions being particularly likely and differently. Here, we induced red flour beetles (Tribolium castaneum) tested their...
Abstract Selection acting on males can reduce mutation load of sexual relative to asexual populations, thus mitigating the two-fold cost sex. This requires that it seeks and destroys same mutations as selection females, but with higher efficiency, which could happen due selection-a potent evolutionary force in most systems predominantly affects males. We used replicate populations red flour beetles (Tribolium castaneum) study sex-specific against deleterious introduced ionizing radiation....
Abstract Variation in the vertebrate major histocompatibility complex (MHC) genes is crucial for fighting pathogen assault. Because new alleles confer a selective advantage, MHC should readily introgress between species, even under limited hybridization. Using replicated transects through two hybrid zones strongly reproductively isolated newts, we demonstrated recent and ongoing introgression. Its extent correlated with age of contact. In older zone, similarity species within exceeded that...