A5052723288- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Healthcare Regulation
- Nail Diseases and Treatments
- Women's cancer prevention and management
- Plant Pathogens and Fungal Diseases
- Nosocomial Infections in ICU
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Infectious Diseases and Mycology
- COVID-19 and Mental Health
- Health, Nursing, Elderly Care
- Antibiotic Resistance in Bacteria
- Infection Control in Healthcare
- Healthcare during COVID-19 Pandemic
- Cytomegalovirus and herpesvirus research
- Public Health in Brazil
- Mosquito-borne diseases and control
- Pleural and Pulmonary Diseases
- Body Image and Dysmorphia Studies
- T-cell and Retrovirus Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Immunodeficiency and Autoimmune Disorders
- Syphilis Diagnosis and Treatment
- Surgical site infection prevention
- Studies on Chitinases and Chitosanases
Universidade Estadual Paulista (Unesp)
2015-2024
São Camilo Hospital
2021
Fundação de Apoio à Universidade Federal de São Paulo
2011-2015
Hospital de Clínicas
2014
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2013
Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that associated with rural environments and agricultural activities. However, the incidence prevalence of paracoccidiodomycosis underestimated because lack compulsory notification. If not diagnosed treated early adequately, endemic infection could result serious sequelae. While Paracoccidioides brasiliensis ( P. ) complex has been known to be causal agent paracoccidiodomycosis, new species, lutzii ), reported...
Paracoccidioidomycosis is a systemic fungal disease associated with agricultural activities. Its incidence and prevalence are underestimated because of the lack reporting in several Brazilian states. If paracoccidiodomycosis not diagnosed treated early adequately, endemic infection may result serious sequelae. In addition to Paracoccidioides brasiliensis (P. brasiliensis) complex, appearance new species, lutzii lutzii), Rondônia state, where has reached epidemic levels, country's Midwest...
Background There are no published reports on studies comparing itraconazole (ITC), sulfamethoxazole-trimethoprim (cotrimoxazole, CMX), and ITC followed by CMX (ITC/CMX) in the treatment of paracoccidiodomycosis. This study aimed to compare efficacy, effectiveness, safety time clinical serologic cure paracoccidioidomycosis patients treated with or CMX, antifungal agents most widely used. Methodology A quasi-experimental was performed 177 a confirmed probable diagnosis paracoccidioidomycosis....
Surgical complications after kidney transplantation can lead to catastrophic outcomes. Frailty has been associated with important outcomes; however, there are no studies assessing this measure of physiological reserve as a specific predictor surgical in population. Such an assessment was, therefore, the objective present study.A total 87 individuals aged ≥ 18 years who underwent between March 2017 and 2018 were included. At time admission for transplantation, demographic, clinical, data...
A review of 400 clinical records paracoccidioidomycosis (PCM) patients, 93 with the acute/subacute (AF) and 307 chronic form (CF), attended from 1977 to 2011, selected as schedule release for study by Office Medical Records at University Hospital Faculdade de Medicina Botucatu – São Paulo State UNESP, was performed detect cases in relapse. The control cure serological evaluation using double agar gel immunodiffusion test (DID). In diagnosis relapse, DID, enzyme-linked immunosorbent assay...
Mutations in genes affecting interferon-γ (IFN-γ) immunity have contributed to understand the role of IFN-γ protection against intracellular pathogens. However, inborn errors STAT4, which controls interleukin-12 (IL-12) responses, not yet been reported. Our objective was determine genetic defect a family with history paracoccidioidomycosis. Genetic analysis performed by whole-exome sequencing and Sanger sequencing. STAT4 phosphorylation (pSTAT4) translocation nucleus, release patient...
Bloodstream infections are responsible for thousands of deaths each year. The rapid identification the microorganisms causing these permits correct therapeutic management that will improve prognosis patient. In an attempt to reduce time spent on this step, microorganism devices have been developed, including VITEK® 2 system, which is currently used in routine clinical microbiology laboratories. This study evaluated accuracy system 400 isolated from blood cultures and compared results those...
Paracoccidioidomycosis (PCM) is a systemic mycosis that diagnosed by visualizing the fungus in clinical samples or other methods, like serological techniques. However, all PCM diagnostic methods have limitations. The aim of this study was to develop tool for based on Fourier transform infrared (FTIR) spectroscopy. A total 224 serum were included: 132 from patients and 92 constituting control group (50 healthy blood donors 42 with mycoses). Samples analyzed attenuated reflection (ATR) t-test...
Paracoccidioidomycosis (PCM) is systemic mycosis caused by the thermal dimorphic fungus of genus Paracoccidioides, leading to either acute/subacute (AF) or chronic (CF) clinical forms. Numerous CF patients after treatment exhibit sequels, such as pulmonary and adrenal fibrosis. Monocytes are cells that involved in inflammatory response during active infection well fibrogenesis. These comprise a heterogeneous population with distinct phenotypic functional activities. The scope this study was...
Catheter-related bloodstream infection (CR-BSI) is one of various complications related to hemodialysis (HD). As a result the high rate infection, use lock solutions for prevention CR-BSI has been studied. However, adverse effects solution, such as increased emergence strains resistant antibiotics, which an important concern, need be investigated further. The aim this study was compare efficacy solution using combination cefazolin and gentamicin versus taurolidine citrate in reducing...
Infection control interventions can be erroneously interpreted if outcomes are assessed in short periods. Also, statistical methods usually applied to compare before and after not appropriate for analyzing time series. To analyze the impact of a bundle directed at reducing incidence ventilator-associated pneumonia (VAP) other device-associated infections two medical-surgical intensive care units (ICU) Brazil. Our study had quasi-experimental design. Interrupted series analyses (ITS) was...
Background: Endemic systemic mycoses remain a health challenge, since these opportunistic diseases are increasingly infecting immunosuppressed patients. The simultaneous use of antifungal compounds and other drugs to treat infectious or non-infectious has led several interactions undesirable effects. Thus, new should be investigated. present study aimed evaluate the activity liriodenine extracted from Annona macroprophyllata on agents mycoses, with emphasis genus Paracoccidioides. Methods:...
Abstract Objectives We aimed to explore angiographic patterns and in‐hospital outcomes of patients with concomitant coronavirus disease‐19 (COVID‐19) myocardial infarction (MI). Background Patients COVID‐19 may experience MI during the course viral infection. However, this association is currently poorly understood. Methods This a multicenter prospective study consecutive who underwent coronary angiography. Quantitative qualitative angiography were analyzed by two observers in an independent...
Patients submitted to hemodialysis are at a high risk for healthcare-associated infections (HAI). Presently there scarce data allow benchmarking of HAI rates in developing countries. Also, most studies focus only on bloodstream (BSI) or local access (LAI). Our study aimed provide wide overview epidemiology unit southeastern Brazil. We present from prospective surveillance carried out March 2010 through May 2012. Rates were compared (mid-p exact test) and temporally analyzed Shewhart control...
Surgical site infections (SSIs) often manifest after patients are discharged and missed by hospital-based surveillance.We conducted a case-reference study nested in prospective cohort of from six surgical specialties teaching hospital. The factors related to SSI were compared for cases identified during the hospital stay discharge.Among 3,427 patients, 222 (6.4%) acquired an SSI. In 138 these onset occurred discharge. Neurological surgery use steroids independently associated with greater...
Imipenem-resistant Acinetobacter baumannii (IRAB) is a major threat for critically ill patients, including those admitted to burn units. Recent studies have suggested that colonization pressure (the proportion of patients or patient-days harbouring the pathogen interest) an important driver risk acquisition multidrug-resistant organisms. With in mind, we conducted cohort study, enrolling 208 unit from November 2008 through December 2009. The outcome interest was IRAB. In addition usual...
Introduction: This study standardized a semi-quantitative dot blotting assay (DB) and quantitative real-time polymerase chain reaction (qPCR) to detect specific antibodies for Paracoccidioides brasiliensis its DNA in PCM patients. Methodology: We evaluated 42 confirmed patients upon admission using serological double agar gel immunodiffusion test (DID), DB, molecular tests (qPCR total blood). The control groups included healthy individuals 37 with other infectious diseases. progress during...
The diagnosis of chronic pulmonary aspergillosis (CPA) depends on the radiologic image and identification specific antibodies. present study aimed to evaluate accuracy parameters enzyme-linked immunosorbent assay (ELISA) determination serum galactomannan level in patients with CPA, comparing these results double agar gel immunodiffusion (DID) test. In addition, prevalence cross-reactivity serological progression after treatment were evaluated by DID ELISA. Six groups formed: G1: 22 17 whom...