A5081958425- COVID-19 Clinical Research Studies
- Advanced Proteomics Techniques and Applications
- Long-Term Effects of COVID-19
- Advanced biosensing and bioanalysis techniques
- Vascular Tumors and Angiosarcomas
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Molecular Biology Techniques and Applications
- Inflammasome and immune disorders
VA Boston Healthcare System
2015-2021
Boston University
2021
Immunotherapies are revolutionizing cancer care, producing durable responses and potentially cures in a subset of patients. However, response rates low for most tumors, grade 3/4 toxicities not uncommon, our current understanding tumor immunobiology is incomplete. While hundreds immunomodulatory proteins the microenvironment shape anti-tumor response, few them can be reliably quantified. To address this need, we developed multiplex panel targeted proteomic assays targeting 52 peptides...
Previous studies of SARS-CoV-2 viral infection suggest that both the humoral and cytotoxic arms immune system are weak in patients with severe COVID-19 disease when compared to mild disease. A cytokine storm is also induced IL-15 has been shown support arm response. IL-21 In addition, some settings, Il-21 actually decrease IL-6 TNF-alpha production, reducing inflammatory proteins involved storm. Furthermore, other combination be more effective than either interleukin alone promoting an...
SARS-Cov-2 is the virus that causes disease COVID-19. While most patients who contract experience mild symptoms, a significant percentage has severe sometimes leading to death. In this paper, immune response infection reviewed, highlighting differences between with and disease.
A 64 year old white male patient was evaluated by colonoscopy for a 6 months history of spontaneous rectal bleeding. He had longstanding tobacco and alcohol use. bulky (4x3 cm) ano-rectal tumor identified during retroflexion the endoscope (Figure 1). Mucosal biopsies were obtained showed an atypical spindle cell type 3) with strong expression Sox-10. Multiple markers tested immunohistochemistry (IHC; see Table 1) which Sox-10, S-100, HBM45, Mart-1was demonstrated positive. In contrast,...