- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Biosimilars and Bioanalytical Methods
- Immunotherapy and Immune Responses
Cancer continues to be the leading cause of mortality in high-income countries, necessitating development more precise and effective treatment modalities. Immunotherapy, specifically adoptive cell transfer T receptor (TCR)-engineered cells (TCR-T therapy), has shown promise engaging immune system for cancer treatment. One biggest challenges TCR-T therapies is proper prediction pairing between TCRs peptide-human leukocyte antigen (pHLAs). Modern computational immunology, using artificial...
<sec> <title>BACKGROUND</title> Cancer continues to be the leading cause of mortality in high-income countries, necessitating development more precise and effective treatment modalities. Immunotherapy, specifically adoptive cell transfer T receptor (TCR)-engineered cells (TCR-T therapy), has shown promise engaging immune system for cancer treatment. One biggest challenges TCR-T therapies is proper prediction pairing between TCRs peptide-human leukocyte antigen (pHLAs). Modern computational...