A5032923467- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Adrenal and Paraganglionic Tumors
- Reproductive System and Pregnancy
- Mechanical Circulatory Support Devices
- Cancer, Hypoxia, and Metabolism
- Inflammatory Bowel Disease
- Adipose Tissue and Metabolism
- Dialysis and Renal Disease Management
- Pharmacological Effects and Toxicity Studies
- Polyomavirus and related diseases
- Cancer Immunotherapy and Biomarkers
- Neurological Complications and Syndromes
- Cardiac Arrest and Resuscitation
- CAR-T cell therapy research
- Regulation of Appetite and Obesity
- Pregnancy and Medication Impact
- Diabetes and associated disorders
- Aortic aneurysm repair treatments
- Glioma Diagnosis and Treatment
Poznan University of Medical Sciences
2015-2025
Centrum Medyczne iMed24
2021
Poznań University of Technology
2010
<h3>Objective</h3> The authors tested whether the anti-interleukin (IL)-17A monoclonal antibody secukinumab was safe and effective for treatment of active Crohn9s disease. <h3>Design</h3> In a double-blind, randomised, placebo-controlled proof-of-concept study, 59 patients with moderate to severe disease (Crohn9s Disease Activity Index (CDAI) ≥220 ≤450) were assigned in 2:1 ratio 2×10 mg/kg intravenous or placebo. primary end point, addressed by Bayesian statistics augmented historical...
Tacrolimus is metabolized in the liver with participation of cytochrome P450 isoforms 3A4 and 3A5 (CYP3A4, CYP3A5). Omeprazole, unlike famotidine, a substrate inhibitor CYP2C19, CYP3A4, CYP3A5 enzymes. The aim study to compare effect omeprazole famotidine on tacrolimus concentration kidney transplant function. A randomized was conducted 24 adult patients stable function who received standard triple immunosuppression regimen. Patients were assigned group I (n = 12) additionally receiving (20...
Many patients with venous leg ulcers do not reach complete healing compression treatment alone, which is current standard care. This clinical trial HEAL LL-37 was a phase IIb double-blind, randomized, placebo-controlled study, the aim to evaluate efficacy and safety of new drug for topical administration, in combination therapy, 148 suffering from hard-to-heal ulcers. The study had three arms, consisting two groups treated at concentrations 0.5 or 1.6 mg/mL, placebo cohort. Patients mean age...
Cancer continues to be the leading cause of mortality in high-income countries, necessitating development more precise and effective treatment modalities. Immunotherapy, specifically adoptive cell transfer T receptor (TCR)-engineered cells (TCR-T therapy), has shown promise engaging immune system for cancer treatment. One biggest challenges TCR-T therapies is proper prediction pairing between TCRs peptide-human leukocyte antigen (pHLAs). Modern computational immunology, using artificial...
Tacrolimus is metabolized in the liver with participation of CYP3A4 and CYP3A5 enzymes. Proton pump inhibitors are used kidney transplant patients to prevent duodenal gastric ulcer disease due glucocorticoids. Omeprazole, unlike famotidine, a substrate inhibitor enzymes CYP2C19, CYP3A4, CYP3A5. The aim this study was compare impact omeprazole famotidine on pharmacokinetics tacrolimus. A randomized, non-blinded involving 22 stabilized adult conducted. Patients received standard triple...
Adropin is a multifunctional peptide hormone encoded by the ENHO (energy homeostasis associated) gene. It plays role in mechanisms related to increased adiposity, insulin resistance, as well glucose and lipid metabolism. The low adropin levels are strongly associated with obesity independent resistance. On other hand, overexpression or exogenous administration of improves homeostasis. multidirectional, adropin-related effects regulation metabolism humans also appear be attributable this on...
Peritoneal dialysis (PD) is a valuable 'home treatment' option, even more so during the ongoing Coronavirus pandemic. However, long-term use of PD limited by unfavourable tissue remodelling in peritoneal membrane, which associated with inflammation-induced angiogenesis. This appears to be driven primarily through vascular endothelial growth factor (VEGF), while involvement other angiogenic signaling pathways still poorly understood. Here, we have identified crucial contribution mesothelial...
Zwilch kinetochore protein (ZWILCH) plays a key role in proper cell proliferation. The upregulation of the
A previous case report described an adrenal incidentaloma initially misdiagnosed as adrenocortical carcinoma (ACC), which was treated with mitotane. The final diagnosis metastatic melanoma of unknown primary origin. However, the patient developed rapid disease progression after mitotane withdrawal, suggesting a protective role for in non-adrenal-derived tumor. aim present study to determine biological response cells obtained from that patient, and other established ACC cell lines, treatment...
Maintaining the viability of organs from donors after circulatory death (DCD) for transplantation is a complicated procedure, time perspective in absence appropriate organizational capabilities, that makes such cases difficult and not yet widespread Poland. We present procedural preparation Poland's first case organ (kidney) DCD donor which perfusion was supported by extracorporeal membrane oxygenation (ECMO). Because this model complex expensive, we used advanced high-fidelity medical...
The discovery of mitochondria-derived peptides (MDPs) has provided a new perspective on mitochondrial function. MDPs encoded by DNA (mtDNA) can act as hormone-like peptides, influencing cell survival and proliferation. Among these humanin been identified crucial factor for maintaining preventing death under various conditions. Adrenocortical carcinoma (ACC) is rare aggressive malignancy that results from adrenal hormone dysfunction. This study aimed to investigate expression in the tissue...
Adrenal tumors, such as adrenocortical carcinoma (ACC), adenoma (ACA), and pheochromocytoma (PCC) are complex diseases with unclear causes treatments. Mitochondria mitochondrial-derived peptides (MDPs) crucial for cancer cell survival. The primary aim of this study was to analyze samples from different adrenal diseases, carcinoma, adenoma, pheochromocytoma, compare them normal tissue determine whether the expression levels mitochondrial open reading frame 12S rRNA type-c (MOTS-c) gene...
Background: “ECMO for Greater Poland” is a program being developed to serve the 3.5 million inhabitants of Poland region (Wielkopolska) based on an approach already implemented in USA1 or Qatar.2,3Method: The complex and takes full advantage ECMO perfusion therapy opportunities save life patients region. main implementation areas are: – treatment with hypothermia;4 reversible severe respiratory failure;5 acute intoxication resulting cardiorespiratory failure6 other critical conditions heart...
The aim of the study was to determine impact gender renal allograft donor and recipient on graft function over a 5-year follow-up period.The 154 kidney grafts from 77 donors transplanted into recipients both genders. Two groups were formed: one group consisted male donors, while other female donors. in each pair, female.71% survived five-year period when male; case rate 62.5%. Depending recipient, rates with survival as follows: 79.2% for (MF); 62.5% (MM). difference between not...