A5032308620- Burn Injury Management and Outcomes
- Injury Epidemiology and Prevention
- Healthcare professionals’ stress and burnout
- Innovations in Medical Education
- Medical Education and Admissions
- Diversity and Career in Medicine
- Patient Satisfaction in Healthcare
- Traumatic Brain Injury Research
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Immunotherapy and Biomarkers
- Chronic Disease Management Strategies
- Colorectal Cancer Treatments and Studies
- Child and Adolescent Health
- Economic and Financial Impacts of Cancer
- Advanced Breast Cancer Therapies
- Health and Wellbeing Research
- Racial and Ethnic Identity Research
- Breast Cancer Treatment Studies
- Family Support in Illness
- Lung Cancer Treatments and Mutations
- Delphi Technique in Research
- Gastric Cancer Management and Outcomes
- Posttraumatic Stress Disorder Research
- Health Policy Implementation Science
- Frailty in Older Adults
Sanofi (United States)
2021-2025
AVEO Oncology (United States)
2024
Boston University
2016-2023
Massachusetts General Hospital
2019-2021
Spaulding Rehabilitation Hospital
2019-2021
Shriners Hospitals for Children - Boston
2019-2021
Harvard University
2019-2021
University of North Carolina at Chapel Hill
2021
IQVIA (United Kingdom)
2021
University of Amsterdam
2021
<h3>Importance</h3> Addressing physician suicide requires understanding its association with possible risk factors such as burnout and depression. <h3>Objective</h3> To assess the between suicidal ideation after adjusting for depression of self-reported medical errors. <h3>Design, Setting, Participants</h3> This cross-sectional study was conducted from November 12, 2018, to February 15, 2019. Attending postgraduate trainee physicians randomly sampled American Medical Association Physician...
Abstract Purpose Current US health policy discussions regarding physician burnout have largely been informed by studies employing the Maslach Burnout Inventory (MBI); yet, there is little in literature focused on interpreting MBI scores. We described symptoms and precision associated with scores physicians. Methods Using item response theory (IRT) analyses of secondary, cross-sectional survey data, we created profiles describing probability physicians’ emotional exhaustion (EE),...
Abstract Background Physician burnout is often assessed by healthcare organizations. Yet, scores from different measures cannot currently be directly compared, limiting the interpretation of results across organizations or studies. Objective To link common to a single metric in psychometric analyses such that group-level assessments can compared. Design Cross-sectional survey. Setting US practices. Participants A total 1355 physicians sampled American Medical Association Masterfile. Main...
Background. Physician wellness is a vital element of well-functioning health care system. Not only physician empirically associated with quality and patient outcomes, but its ramifications span individual, interpersonal, organizational, societal levels. The purpose this study was to explore academic physicians' perceptions about their work-related wellness, including the following questions: (a) What are workplace barriers facilitators wellness? (b) solutions do theythinkwouldimprove (c)What...
Abstract Purpose Thresholds for meaningful within-individual change (MWIC) are useful interpreting patient-reported outcome measures (PROM). Transition ratings (TR) have been recommended as anchors to establish MWIC. Traditional statistical methods analyzing MWIC such mean analysis, receiver operating characteristic (ROC) and predictive modeling ignore problems of floor/ceiling effects measurement error in the PROM scores TR item. We present a novel approach estimation multi-item scales...
Abstract Background Many patients receiving adjuvant endocrine therapy (ET) for breast cancer experience side effects and reduced quality of life (QoL) discontinue ET. We sought to describe these issues develop a prediction model early discontinuation Methods Among with hormone receptor–positive HER2-negative stage I-III the Cancer Toxicities cohort (NCT01993498) who were prescribed ET between 2012 2017, upon stratification by menopausal status, we evaluated patterns including treatment...
In June 2021, the US Food and Drug Administration (FDA) released a draft guidance for industry on core patient-reported outcomes (PROs) related considerations instrument selection trial design in registrational cancer clinical trials, building prior communications about use of PROs to assess efficacy tolerability oncology drug development. The International Society Quality Life Research (ISOQOL) Standards Best Practices Committee led an initiative commentary guidance, focusing its positive...
Abstract Background Disparities in US physician burnout rates across age, gender, and specialty groups as measured by the Maslach Burnout Inventory-Human Services Survey for Medical Personnel (MBI) are well documented. We evaluated whether disparities explained differences MBI’s functioning groups. Methods assessed measurement equivalence of MBI multi-group item response theory- (IRT-) based differential (DIF) analyses using secondary, cross-sectional survey data from physicians ( n = 6577)....
Abstract Background In the EMPOWER‐Lung 1 trial ( ClinicalTrials.gov , NCT03088540), cemiplimab conferred longer survival than platinum‐doublet chemotherapy for advanced non–small cell lung cancer (NSCLC) with programmed death‐ligand (PD‐L1) ≥50%. Patient‐reported outcomes were evaluated among participants. Methods Adults NSCLC and Eastern Cooperative Oncology Group performance status 0 to randomly assigned 350 mg every 3 weeks or chemotherapy. At baseline day of each treatment cycle,...
Abstract Due to the rapid developmental growth in preschool-aged children, more precise measurement of effects burns on child health outcomes is needed. Expanding upon Shriners Hospitals for Children/American Burn Association Outcome Questionnaire 0 5 (BOQ0–5), we developed a conceptual framework describing domains important assessing recovery from burn injury among children (1–5 years). We working based BOQ0–5, National Research Council and Institute Medicine’s Model Child Health, World...
Abstract Pediatric burn injuries can alter the trajectory of survivor’s entire life. Patient-centered outcome measures are helpful to assess unique physical and psychosocial needs long-term recovery. This study aimed develop a conceptual framework measure pediatric outcomes in survivors aged 5 12 years as part School-Aged Life Impact Burn Recovery Evaluation Computer Adaptive Test (SA-LIBRE5–12 CAT) development. conducted systematic literature review guided by WHO International...
Purpose: Quantifying patient-perceived benefits and disadvantages of treatments in a real-world setting is increasingly important healthcare decision-making. The Patient's Qualitative Assessment Treatment (PQAT) assesses treatment, associated trade-offs potentially influencing patients' willingness to continue treatment. It has then been modified capture perceived magnitude treatment quantitatively, as well qualitatively (PQATv2). However, the PQAT PQATv2 were designed for use validated...
9078 Background: Cemiplimab, a PD-1 inhibitor, improved survival and progression-free vs platinum doublet chemotherapy (chemo) in patients (pts) with advanced NSCLC PD-ligand(L)1 expression ≥50% the EMPOWER-Lung 1 Phase 3 study (NCT03088540). Since pts have high symptom burden that adversely impacts QoL functioning, these outcomes were evaluated as secondary endpoints clinical trial. Methods: Pts PD-L1 ECOG performance status ≤1 randomized to IV cemiplimab 350 mg Q3W (n=356) or chemo...
Due to rapid developmental growth in young children there is a need for more precise measurement of the effects burn injury on child health and development. In an effort expand upon Burn Outcome Questionnaire0-4, we built established conceptual framework inform development Preschool Life Impact Recovery Evaluation (Preschool LIBRE) computer adaptive test (CAT). We performed literature review, consulted with clinical experts, conducted clinician focus groups identify outcomes impacted by...
<h3>Background</h3> The importance in measurement and analysis of patient-reported outcomes (PROs) early oncology development as toxicity efficacy endpoints— particularly with the emergence targeted therapies immunotherapies, has been recognized among researchers.<sup>1-6</sup> Recently, more attention directed towards considerations for applying PROs to by FDA public workshops.<sup>7,8</sup> Despite their value, methods collecting, analyzing, interpreting phase PRO data are complex, leading...