Abstract The effective control of pathogenic bacteria is crucial in the restoration periodontal tissue affected by periodontitis. Guided regeneration (GTR) membranes are commonly used to aid repair defects. Therefore, there a clear advantage developing antibacterial that can effectively eliminate infections and promote regeneration. This study aimed create collagen membrane with optimal content silver nanoparticles (AgNPs) for properties minimal toxicity mammalian cells. Ascorbic...

Abstract Objective Proteus mirabilis is related to serious infections. The present study was designed investigate the minimum inhibitory concentration (MIC) of silver nanoparticles (AgNPs) and zinc oxide (ZnONPs) cytotoxicity among P. isolates recovered from clinical samples in Shiraz. Results A total 100 were screened by biochemical tests polymerase chain reaction (PCR). Also, 25 (25%) 7 (7%) positive for extended-spectrum beta-lactamase (ESBLs) carbapenemase, respectively. Synthesized...

Background: Zataria multiflora Boiss. is a traditional and popular spice in Iran. The effects of 3 ecotypes (ECTPs) Z. essential oils (EOs) against most common causes food-borne nosocomial infections were evaluated. Materials Methods: antimicrobial activities the EOs examined by broth microdilution method as recommended Clinical Laboratory Standards Institute (CLSI). chemical compositions from ECTPs have been analyzed gas chromatography-mass spectrometry. Results: Analysis indicated that...

Nosocomial pathogens are associated with increased hospital stay lengths and mortality rates. Increasing resistance to antibiotics makes the treatment of these infections more difficult. Novel antimicrobial compounds derived from natural sources may be useful for addressing antiobiotic resistance. The objective this study is determine chemical composition activities essential oils Myrtus communis L. (Myrtaceae) leaves against causing nosocomial infections. oil M. was analysed by gas...

Today an alternative approach to control bacterial infections is the use of natural and traditional plant compounds interfere with their quorum-sensing (QS) systems. In this study, antibacterial anti-QS sensing activity Syzygium aromaticum, Dionysia revoluta Boiss. Eucalyptus camaldulensis Dehnh. were evaluated. These plants are local Middle East region have since ancient times been used for activity. Plant extracted n-hexane, methanol 96% ethanol mixed solvent. Antibacterial herbal extracts...

Background and Objectives: Increasing antimicrobial resistance among Acinetobacter baumannii (A. baumannii) strains poses a significant challenge, particularly in intensive care units (ICUs) where these bacteria are common causes of hospital infections. Biofilm production is recognized as key mechanism contributing to this resistance. This study aims explore the relationship between biofilm production, presence biofilm-associated genes, antibiotic patterns A. isolates obtained from ICU...

ABSTRACT Objectives Fixed orthodontic appliances are associated with higher levels of plaque and saliva bacteria, which contribute to dental caries. The effects combining xylitol fluoride, both used in caries prevention, uncertain. Thus, this study assessed the combined impact fluoride varnish on bacteria biofilms around brackets. Materials Methods A single‐center, four‐arm, parallel‐group, triple‐blind, randomized clinical trial was conducted. total 120 patients who required fixed treatment...

Opportunistic infections such as Pseudomonas aeruginosa, colonized from the oral cavity, are common in candidates of bone marrow transplantation. Therefore, it is important to prescribe appropriate antibiotics for this group debilitated patients. In study, we aimed investigate antibiotic resistance aeruginosa encountered transplantation referred Imam Reza Clinic, Namazi Hospital, and Amir Shiraz, Iran. This cross-sectional study was performed on 30 patients with leukemia lymphoma. To...

Molecular typing such as spa is used to control and prevent Staphylococcus aureus widespread in hospitals communities. Hence, the aim of this study was find most common types S. strain circulating Shiraz via SCCmec methods.Total 159 isolates were collected from two tertiary Shiraz. Isolates identified by biochemical tests. Antimicrobial susceptibility tests performed standard disk diffusion method then genetic analysis bacteria using typing. In 31.4% methicillin-resistant aureus. The...

Hypervirulent Klebsiella pneumoniae (hvKp) pathotype is emerging worldwide in pyogenic liver abscesses (PLAs). However, the role of virulence factors pathogenicity remains unclear. On other hand, epidemiology PLAs Iran unknown. From July 2020 to April 2022, bacterial species were isolated and identified from drainage samples 54 patients with PLAs. K. as most common pathogen was 20 (37%) patients. We analyzed clinical microbiological characteristics -related abscesses. Antibiotic...

To find out if a functional promoter polymorphism in the IL-8 gene along with cagA status and polymorphisms vacA influence type of diseases Iranian patients infected by H pylori.IL-8 -251 A/T was genotyped oligonucleotide allele specific PCR (ASO-PCR) sample 233 pylori infection undergoing upper gastrointestinal endoscopy. The presence also determined PCR. Association these genetic development gastritis, peptic ulcers as well gastric cancer tested.When different clinical manifestations were...

This study aimed to investigate the clarithromycin resistance and its associated molecular mechanisms among Helicobacter pylori isolates from dyspeptic patients in Shiraz, Iran. From January May 2014, 100 H. strains were isolated with gastroduodenal disorders. The was quantitatively evaluated, using Epsilometer (E‐test) method. Polymerase chain reaction‐restriction fragment length polymorphism ( PCR ‐ RFLP ) performed on all detect A2143G A2142G mutations 23S rRNA gene. isolation rate found...

Aims and Objectives: Dentures in the oral cavity may act as a reservoir of microorganisms, which be related to systemic infections. The aim this study was investigate nonoral pathogenic bacteria patients with removable dentures Shiraz, Southern Iran. Materials Methods: bacterial flora saliva samples from 50 men women 100 age- sex-matched controls normal dentate were compared using culture, Gram staining, API20E Kit methods. All data analyzed SPSS software. Results: Except for Enterobacter...

Objectives:Helicobacter pylori (H. pylori) infection caused by antibiotic-resistant strains represents a major public health threat that aggressively promotes gastric cancer progression. Antibiotic resistance evaluation is immensely important to counteract its emergence. Here we merely determine the prevalence of antibiotic in H. isolates and correlation with cagA motifs homB gene. Methods: The pattern was investigated on 128 isolated utilizing disk diffusion method study between it presence...

INTRODUCTION The aim of this study was to detect the prevalence extended-spectrum beta-lactamase (ESBL)-encoding CTX-M gene in Escherichia coliisolates. METHODS: Phenotypic screening 376 E. coli isolates for ESBL conducted using disk diffusion. ESBL-producing were tested PCR and specific primers. bla cluster identified RFLP method, its genotype sequenced. RESULTS: From 202 , 185 (91.5%) possessed genes. CTX-M-1 subtypes found 98% isolates. identical CTX-M-15. CONCLUSIONS: A high...

is one of the most important hospital pathogenic bacteria that cause infectious diseases. The present study aimed to determine frequency carbapenem resistance genes in association with transposable elements and molecular typing carbapenem-resistant

Objective. Helicobacter pylori infection is accompanied by inflammatory processes leading to peptic ulcer and gastric cancer in the minority of infected individuals. The interaction between H. virulence factors, host defense mechanisms environmental factors determine outcome clinical manifestations. One involved inflammation carcinogenesis peroxisome proliferator-activated receptor-γ (PPAR-γ) molecule. present case–control study aimed polymorphism PPAR-γ gene its association with...