A5063383373- Circadian rhythm and melatonin
- Plant Molecular Biology Research
- Light effects on plants
- Neurobiology and Insect Physiology Research
- Genetics, Aging, and Longevity in Model Organisms
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
University of California, Davis
2015-2024
Codon usage bias is a universal feature of all genomes, but its in vivo biological functions animal systems are not clear. To investigate the role codon animals, we took advantage sensitivity and robustness Drosophila circadian system. By codon-optimizing parts period ( dper ), core clock gene that encodes critical component oscillator, showed important for function. optimization resulted conformational changes dPER protein, altered phosphorylation profile stability, impaired function...
The animal circadian timing system interprets environmental time cues and internal metabolic status to orchestrate rhythms of physiology, allowing animals perform necessary tasks in a time-of-day-dependent manner. Normal progression is dependent on the daily cycling core transcriptional factors that make up cell-autonomous molecular oscillators. In Drosophila , PERIOD (PER), TIMELESS (TIM), CLOCK (CLK), CYCLE (CYC) are clock proteins function transcriptional–translational feedback mechanism...
Abstract Circadian clocks respond to temperature changes over the calendar year, allowing organisms adjust their daily biological rhythms optimize health and fitness. In Drosophila , seasonal adaptations compensation are regulated by temperature-sensitive alternative splicing (AS) of period ( per ) timeless tim genes that encode key transcriptional repressors clock gene expression. Although clk encodes critical activator expression, AS its transcripts potential role in regulation function...
Circadian clocks control daily rhythms in behavior and physiology. In Drosophila, the small ventral lateral neurons (sLNvs) expressing PIGMENT DISPERSING FACTOR (PDF) are master pacemaker generating locomotor rhythms. Despite importance of sLNvs PDF circadian behavior, little is known about factors that maintenance accumulation. Here, we identify Drosophila SWI2/SNF2 protein DOMINO (DOM) as a key regulator behavior. Depletion DOM eliminates morning anticipatory activity under light dark...
Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms physiology behavior with 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping, regulated by transcription factor binding, RNA polymerase II (RNAPII) recruitment elongation, post-transcriptional mechanisms. Recently, it has become clear that dynamic alterations chromatin landscape at level histone posttranslational modification...
Circadian clocks respond to temperature changes over the calendar year, allowing organisms adjust their daily biological rhythms optimize health and fitness. In Drosophila , seasonal adaptations are regulated by temperature-sensitive alternative splicing (AS) of period ( per ) timeless tim genes that encode key transcriptional repressors clock gene expression. Although Clock Clk encodes critical activator circadian expression, AS its transcripts potential role in regulation function have not...
Circadian clocks endow organisms with the ability to temporally coordinate and synchronize their physiology surrounding environment, thereby conferring an adaptive advantage. Although specific clock genes are not highly conserved, basic design regulation of circadian oscillator is remarkably similar across species. In Drosophila melanogaster , central exists as interconnected transcriptional translational feedback loops that drive sustain rhythm. Essential this regulatory network activator...
Abstract Circadian clocks control daily rhythms in physiology. In Drosophila , the small ventral lateral neurons (sLN v s) expressing PIGMENT DISPERSING FACTOR (PDF) are master pacemaker neurons. Despite importance of sLN s and PDF circadian behavior, little is known about factors that maintenance accumulation. Here, we identify SWI2/SNF2 protein DOMINO (DOM) as a key regulator behavior. Depletion DOM eliminates morning anticipation impairs rhythmicity. Interestingly, two splice variants...