Prostate cancer (PC) affects millions of men, causing high mortality rates. Despite the treatment approaches, options for metastatic castration-resistant prostate (mCRPC), a lethal form advanced PC, are still limited. Cabazitaxel (Cbx) is last taxane-derived chemotherapeutic approved Docetaxel- resistant mCRPC patients. However, its effects limited due to activation several pathways. Therefore, new approaches needed increase efficacy Cbx. Usnic acid (UA) natural product with wellknown...

An effective pain control is important in early mobilization and returning to normal daily life following percutaneous nephrolithotomy (PCNL) operations. The use of an intraoperative local anaesthetic or postoperative analgesic has been reported for PCNL. Transmuscular quadratus block (QLB III) a regional technique applied under ultrasound guidance. aim this study was investigate the effectiveness QLB III on PCNL.This prospective, randomized, double-blinded carried out at Dr Ersin Arslan...

A subset of renal cell carcinoma (RCC) patients has been shown to respond anti-EGFR therapy. As KRAS and BRAF mutations are associated with poor response therapy in some cancers, it suggested that screening for RCC may be a promising strategy identify who might EGFR-targeted The aim this study was investigate the mutation status EGFR, patients. Renal tumors normal samples from forty-eight underwent radical or partial nephrectomy kidney cancer were used study. Histological classification...

The study aims to compare the effectiveness, safety and costs of two different anesthesia methods in percutaneous nephrolithotomy (PCNL) operations.In our study, data was retrospectively examined 1657 patients who underwent PCNL due renal calculi between 2009 2017. Patients were separated into groups according type anesthesia; as those by general (GA) (n = 572) under spinal anesthe-sia(SA) 1085). Standard technique used both groups. Gender, age, operation duration, period hospitalization,...

Fournier’s Gangrene is a mortal disease. Monitoring of the prognosis patients utmost importance while planning treatment strategies. To evaluate platelet mass index (PMI) calculated by multiplying count mean volume, Uludag Severity Index (UFGSI) and some biochemical markers including Mg, for predicting mortality in single-center patient population with (FG). The medical records were reviewed 46 FG who treated followed up tertiary care center between May 2005 November 2017 . history patients,...

Penile cancer risk increases significantly with increasing age, poor hygiene, and the presence of a foreskin. The most frequently observed type is squamous cell carcinoma (SCC). Clinical examination inguinal lymph nodes critical, as nodal involvement prognostic feature. Patients T2 or higher-grade tumors lymphovascular invasion are at high probably should have node dissection.

NSCLC accounts for 80-85% of lung cancer cases, a major global mortality factor. Identifying treatment-responsive biomarkers in is crucial real-time therapeutic evaluation. Tumor-derived exosomes and their mRNAs are recognized influencing tumor dynamics within the microenvironment. The Hippo HIF1A pathways central to progression potential targets NSCLC. Despite research advances, specific treatment-related molecular mechanisms remain incompletely understood. This study aimed assess pathway...

Numerous research studies have explored the impact of micronutrients, including dietary minerals such as iron, zinc, selenium, copper, and vitamins A, B complex, C, D, E, on periodontitis. However, there is no literature investigating role iodine in periodontal health.

Emphysematous pyelonephritis (EPN) is an acute severe necrotizing infection of the renal parenchyma and its surrounding tissues that results in presence gas parenchyma, collecting system or perinephric tissue. Our case was a 46-year-old diabetic woman who referred to us from emergency department. This first emphysematous caused by Candida species English literature.

Objective: To build up a new microcontroller thermoelectric system to achieve renal hypothermia.Material and methods: Renal hypothermia was tested under in vivo conditions the kidneys of ten Mongrel dogs.Ambient temperature evaluated using two different microcontrollers.In order ensure parenchyma, selection can be made among 4 modules sensors which detect area.The range adjusted between -50°C +50°C.Results: When single double poles kidney were cooled, initial mean intraperitoneal values...

ÖzWhat's known on the subject?and What does study add?Amaç: Bu çalışmanın amacı, lokalize prostat kanseri nedeniyle radikal prostatektomi yapılan hastalarda preoperatif trombosit kitle indeksi (PMI) ile tümörün patolojik özellikleri ve postoperatif biyokimyasal nüks arasındaki ilişkiyi araştırmaktır.Gereç Yöntem: Nisan 2004 2017 arasında 141 hastanın verileri retrospektif olarak tarandı.Hastaların yaş, spesifik antijen (PSA), sayısı, ortalama hacmi PMI değerleri, N/L oranı, tümör evresi,...

Introduction: The relationship between inflammation and cancer has long been the focus of researchers' interest. There are many inflammatory markers studied for this purpose in literature. In context, we focused on effects platelet counts mass index (PMI) as diagnosis low-volume localized testicular cancer. Materials methods: Thirty-eight patients with a mean age 30.84 ± 5.79 years 38 varicocele control group 32.8 9.7 were enrolled study. Number platelets, volume value PMI calculated from...

Triple-negative breast cancer (TNBC) is a heterogeneous disease with poor prognosis and can be classified into different molecular subtypes. There need to develop computer-aided diagnosis system artificial intelligence (AI) techniques increase the accuracy of evaluating suspicious lesions identifying A multi-gene analysis panel consisting 14 genes 2 reference was designed from TCGA, cBioportal datasets, which were determined in accordance silico analyses 488 TNBC patients (TCGA:123,...

Die Behandlung mit PD1/PD-L1-Inhibitoren erlangt eine zunehmende Bedeutung in der Erstlinientherapie des fortgeschrittenen nicht-kleinzelligen Lungenkarzinoms (NSCLC). Rolle einer präoperativen Immunmodulation bei Patienten im multimodalen kurativen Behandlungskonzept ist aufgrund fehlender Daten unklar. NEOMUN-Studie (NCT03197467) wurde konzipiert, um den Stellenwert neoadjuvanten Anti-PD-1-Immuntherapie vor kurativ intendierter Resektion zu überprüfen.

Objective: To present our initial experience on laparoscopic transperitoneal nephrectomies and to report the perioperative postoperative outcomes in patients with kidney tumor. Materials Methods:We retrospectively evaluated clinical data, laboratory results radiological findings of 40 who underwent renal surgery performed by a single surgeon center between November 2017 May 2019.Thoracoabdominopelvic computed tomography was all patients.Results: A total (26 males (65%), 14 females (35%)...

Objective: To evaluate the importance of preoperative plateletcrit value predicting malignancy in patients who undergo open surgery due to small renal masses. Material and methods: Sixty-eight underwent partial or radical nephrectomy for masses were included this retrospective study. In routine blood tests, ultrasonography contrast-enhanced computed tomography performed all patients. Preoperative values compared with clear cell carcinoma (Group 1, 57 patients) benign lesions 2, 11 patients)....