Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) from ¹⁸F-FDG PET/CT are emerging prognostic biomarkers in various human cancers. This study examined the value of these metabolic parameters measured by pretreatment patients with salivary gland carcinomas. <b>Methods:</b> Forty-nine intermediate- or high-grade carcinomas who underwent definitive surgery without radiotherapy chemoradiotherapy were evaluated preoperatively PET/CT. Maximum standardized uptake values...

Objective To verify that tinnitus itself could disturb speech perception and to evaluate the effects of masking noise on ability in patients with normal hearing but unilateral chronic using test. Study Design Prospective, nonrandomized study. Materials Methods Between June 2009 May 2011, we enrolled 20 subjective had persisted for more than 12 months, along healthy controls same age. All subjects were evaluated audiologic examinations, handicap inventory, Korean version Hearing Noise Test...

<h3>Objectives</h3>To investigate the long-term clinical efficacy and stability of thyroplasty type I for unilateral vocal cord palsy, to identify appropriate timing posttreatment evaluations determination voice outcome.<h3>Study Design</h3>Single-institution retrospective study.<h3>Setting</h3>Academic tertiary referral centers in Korea.<h3>Patients</h3>Forty patients with palsy who underwent from January 1, 1996, through December 31, 2006, were followed up at least 5 years after surgical...

Background We examined the prognostic value of lymph node density in predicting cancer-specific mortality (CSM) for patients with nodes positive (pN+) laryngeal squamous cell carcinoma (SCC) after laryngectomy. Methods The records 156 SCC who initially underwent curative resection primary tumor combined neck dissection were reviewed. Results 5-year cumulative incidence CSM was 20.4%. N classification and extralaryngeal spread (ELS) independent variables all patients. Univariate analyses 71...

Objective: Three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) magnetic resonance imaging (MRI) has recently been applied to the inner ear, but relationship between 3D-FLAIR findings and audiovestibular function unclear in patients with sudden sensorineural hearing loss (SSNHL). We therefore used MRI investigate vestibular lesions SSNHL determined correlation these radiologic results of tests. Study Design: Prospective study. Methods: enrolled 35 who presented from 2008 2009....

Abstract Background We investigated whether the addition of narrow band imaging (NBI) to standard diagnostic workups could enhance detection primary lesions in patients with carcinoma unknown (CUP). Methods Thirty CUP underwent NBI endoscopy and fluorodeoxyglucose–positron emission tomography/CT (FDG‐PET/CT) after thorough conventional between 2009 2011. Sites suspected harboring tumors, as determined by and/or FDG‐PET/CT, were biopsied for histologic confirmation. Results Occult tumors...

Background We compared clinical outcomes between patients with salivary gland carcinomas preoperatively misdiagnosed as benign lesion and properly diagnosed malignant lesion. Methods The were (44 each) on preoperative fine‐needle aspiration cytology diagnosis who underwent conservative or radical surgery. Results Five‐year lesion‐free survival (DFS) rates 86.8% for 76.3% ( p = .128). Surgical extent did not significantly affect locoregional recurrence DFS .360). Univariate analysis showed...

Introduction: The authors assessed clinical presentations and anatomic variants among patients with recurrent acute rhinosinusitis (RARS), chronic (CRS) without nasal polyps (CRSsNP), CRS (CRSwNP). Additionally, differences in the postoperative improvement of each category were evaluated. Methods: performed an analysis 304 who underwent endoscopic sinus surgery. They divided into groups RARS, CRSsNP, CRSwNP. Patients had to complete Sino-Nasal Outcome Test (SNOT-20) on surgery 1 day before 6...

Background: Facial or head pain is not an infrequent symptom among patients diagnosed with chronic rhinosinusitis (CRS), but few reports have investigated the in CRS, including relationship between and sites of CRS. The aim this study was to investigate whether related location lesions on computed tomography (CT) Methods: We analyzed 203 who underwent endoscopic sinus surgery (ESS) for 2 years. Patients were assessed using questionnaires pain, provided 1 day prior operation 6 months post...

Induction chemotherapy (ICT) may reduce rates of distant metastases and enhance organ preservation survival in patients with hypopharyngeal cancer. The authors compared data who underwent chemoradiotherapy or surgery after ICT investigated whether response to is a predictive marker for outcome cancer.Historical cohort study.Tertiary-care hospital.The enrolled 97 (89 men, 8 women; mean age 61.2 years; range, 29-80 years) previously untreated cancer between January 1997 December 2006 at Asan...

Ortner's syndrome is a rare clinical entity with hoarseness attributable to recurrent laryngeal nerve palsy in cardiovascular diseases. The mechanism of this condition thought be due compression the by dilated, tense structure against its adjacent tissue; thus, also known as cardio-vocal syndrome. We experienced case 81-year-old female suffering from large aneurysm aortic arch, and reviews literature for possible causes Key words: Vocal cord paralysis ㆍ Ortner’s Cardio-vocal

Objectives：Even though headache is a common symptom in patients with chronic rhinosinusitis (CRS) or nasal septal deviation (NSD), there are very few recent reports investigating characteristics rhinologic patients.Therefore, we investigated the and differences CRS NSD who were diagnosed by computerized tomography endoscopic exams.Methods：We enrolled 257 had undergone sinus surgery between January 2012 December 2013.The subjects divided into group (n=147) (n=110).They asked to fill out...

Lingual thyroid is an uncommon developmental anomaly and the result of failure to descend from foramen cecum its prelaryngeal site during embryogenesis.Massive bleeding a lingual unusual symptom occasionally fatal.Current surgical treatment options range tumor extirpation or transposition excision reimplantation.The use CO 2 laser for removal offers advantages over traditional managements.We experienced case which was successfully excised via transoral approach using laser.We discussed...

Abstract Overexpression of MDM2 or MDMX inactivates the tumor-suppressive function p53. Restoration p53 counteracting these repressors can lead to in vivo tumor regression. Therefore, we evaluated whether restoration by a small-molecule activator XI-011, pseudouria derivative NSC146109, induce apoptosis head-and-neck cancer (HNC). The effects XI-011 treatment four HNC cell lines were tested, individually combination with nutlin-3a, an inhibitor MDM2-p53 interactions, and its growth...

론 최근

Abstract Overexpression of MDM2 inactivates the tumor suppressive function p53 and a small-molecule reactivation induction cell apoptosis (RITA) disrupts MDM2-p53 interaction. We evaluated whether restoration by RITA enhances cytotoxicity cisplatin in head-and-neck cancer (HNC). was tested four human HNC lines differing TP53 status. In vitro vivo growth suppression, cycle arrest, after treatment individually or combination with were assessed. induced prominent accumulation wild-type...

Free accessAbstractFirst published online August 2010Usefulness of Induction Chemotherapy in Hypopharynx CancerIn Sun Ryu, presenterView all authors and affiliationsVolume 143, Issue 2_supplhttps://doi.org/10.1016/j.otohns.2010.06.826