A5030767672- Phytochemistry and Biological Activities
- Metabolomics and Mass Spectrometry Studies
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Algal biology and biofuel production
- Medicinal plant effects and applications
- Carbohydrate Chemistry and Synthesis
- Traditional Chinese Medicine Analysis
- Biodiesel Production and Applications
- Hormonal and reproductive studies
- Food Chemistry and Fat Analysis
- Plant chemical constituents analysis
- Biochemical Analysis and Sensing Techniques
- Ginseng Biological Effects and Applications
- Pharmacogenetics and Drug Metabolism
- Analytical Chemistry and Chromatography
- Ziziphus Jujuba Studies and Applications
- Phytochemical Studies and Bioactivities
- Cocoa and Sweet Potato Agronomy
- Enzyme-mediated dye degradation
- Traditional and Medicinal Uses of Annonaceae
- Sesquiterpenes and Asteraceae Studies
- Phytochemistry and biological activities of Ficus species
Janssen (Belgium)
2021-2024
University of Antwerp
2013-2020
Flemish Institute for Technological Research
2013-2019
<i>Filipendula ulmaria</i> (meadowsweet) is traditionally used for the treatment of inflammatory diseases and as a diuretic antirheumatic. Extracts Filipendulae herba are on market in European Union food supplements. Nevertheless, its active constituents remain to be revealed. During this study, phytochemical composition Ulmariae Herba was comprehensively characterised first time with two complementary generic ultrahigh-performance liquid chromatography-photodiode array-accurate mass...
Abstract Plant species of the genus Cecropia (Urticaceae) are used as traditional medicine in Latin-America, and commercially available food supplements. The aim this study was to characterize compare phytochemical constituents four collected Panama. structures 11 compounds isolated from leaves C. obtusifolia were elucidated based on high resolution mass spectrometry (HRMS) nuclear magnetic resonance (NMR) spectroscopic analysis; polyphenolic all commercial products characterized using...
Abstract This work explored the biotechnological potential of medicinal halophyte Artemisia campestris subsp. maritima (dune wormwood) as a source health promoting commodities. For that purpose, infusions, decoctions and tinctures were prepared from roots aerial-organs evaluated for in vitro antioxidant, anti-diabetic tyrosinase-inhibitory potential, also polyphenolic mineral contents toxicity. The dune wormwood extracts had high content several phenolics identified by ultra-high performance...
Several Cecropia (Cecropiaceae) species are traditionally used in Latin America for the treatment of a variety diseases including diabetes, arterial hypertension, asthma, bronchitis, anxiety, and inflammation. At present, number commercial products based on these plants have been introduced into market with very little information methods guaranteeing their quality safety.This work proposes potential chemical markers control raw materials obtusifolia Bertol., peltata L., glaziovii Snethl.,...
Vegetables are a major source of carotenoids and identified as potentially important natural antioxidants that may aid in the prevention several human chronic degenerative diseases. Characterization organic biological matrices is crucial step any research valorization trajectory. This study reports for first time use high mass resolution exact orbitrap technology elucidation carotenoid fragmentation pathways. contributes to generation new tools identifying unknown based on patterns. Two...
To screen and identify biosurfactant-producing Pseudomonas strains isolated from floral nectar; to characterize the produced biosurfactants; investigate effect of different carbon sources on biosurfactant production.Four eight nectar isolates were found produce biosurfactants. Phylogenetic analysis based three housekeeping genes (16S rRNA gene, rpoB gyrB) classified into two groups, including one group closely related fluorescens another fragi jessenii. Although our pseudomonads able grow a...
Abstract Cecropia species are traditionally used in Latin American folk medicine and available as food supplements with little information warranting their quality. The optimum conditions for the extraction of chlorogenic acid (CA), total flavonoids (TF) flavonolignans (FL) from leaves were determined using a fractional factorial design (FFD) central composite (CCD). A reversed-phase high-performance liquid chromatographic method coupled to diode array detector (HPLC-DAD) was validated...
In Alzheimer's disease (AD) brain, one of the histopathological hallmarks is neurofibrillary tangles consisting aggregated and hyperphosphorylated tau. Currently many tau binding antibodies are under development to target extracellular species responsible for spreading in brain. As such, an in-house developed antibody JNJ-63733657 with picomolar affinity towards phosphorylated at both T212 T217 (further named p217+tau) was recently tested phase I clinical trial NCT03375697. Following...
Herniaria hirsuta L. (Caryophyllaceae) is used for treatment of urinary stones and as a diuretic. Little known about the active compounds mechanism action. The phytochemical composition H. was comprehensively characterized using UHPLC-UV-HRMS (Ultrahigh-Performance Liquid Chromatography-Ultraviolet-High Resolution Mass Spectrometry) data. An in vitro gastrointestinal model to simulate biotransformation, which allowed monitoring relative abundances individual over time. To analyze...
The aim of the present study was to develop a generic analytical method for identification and quantitation apolar plant metabolites in biomass using liquid chromatography-photodiode array-accurate mass spectrometry (LC-PDA-amMS). During this study, single sample preparation protocol applied extract metabolites. Compound performed screening compounds without need dedicated fractionation. Such approach renders vast amounts information is virtually limited by only solubility detector response...
Postpartum haemorrhage (PPH) is the leading cause of maternal mortality worldwide. To prevent PPH, WHO recommends administration oxytocin (OT) immediately after birth, i.e. during third stage labour (TSL). Previous studies demonstrate that methods to quantify OT in biological matrices, e.g. enzyme-linked immunosorbent assays (ELISA), radioimmunoassays (RIA) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) lack specificity and/or sensitivity accurately plasma from women...
Stone diseases present a major health problem in the Western society, since both urinary and biliary stones occur with relatively high prevalence of 10-12 % 10-20 %, respectively, demonstrate recurrence rate. At moment treatment is mainly based on interventional procedures, or prophylactic dissolution therapy. However, many current drugs cause severe side effects, therefore, there an increasing interest natural medicines. no registered herbal medicinal products are available for gallstones....
The isolation and identification of the flavonoids present in a decoction Desmodium adscendens was performed. In view oral use decoction, this work focused on stability gastrointestinal conditions biotransformation by intestinal microflora colon D-pinitol, vitexin flavonoid fraction as first step unravelling its behaviour human body.The freeze-dried subjected to column chromatography. Subsequently an enriched fraction, separated repeated semi-preparative high-performance liquid...
Saponification is most often used to hydrolyze glycerolipid interferences during carotenoid analysis. Ester bonds of other plant metabolites such as carotenoids are, however, also hydrolyzed saponification, thus altering the natural composition. A straightforward and selective cleanup procedure was therefore developed involving enzymatic hydrolysis matrix glycerolipids. The optimized (100 μL extracted vegetable or algal oil in 20 mL 50:50 phosphate buffer/methanol with 25 sodium n-octyl...