A5062557643- Cholinesterase and Neurodegenerative Diseases
- Pesticide Exposure and Toxicity
- Computational Drug Discovery Methods
- Advanced biosensing and bioanalysis techniques
- Metal-Organic Frameworks: Synthesis and Applications
- DNA and Nucleic Acid Chemistry
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Insect and Pesticide Research
- Natural product bioactivities and synthesis
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Covalent Organic Framework Applications
- RNA and protein synthesis mechanisms
- Animal testing and alternatives
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical synthesis and alkaloids
- Environmental Toxicology and Ecotoxicology
- Phytochemical Studies and Bioactivities
- Synthesis of Organic Compounds
- Thermal and Kinetic Analysis
- Radioactive element chemistry and processing
- Phytochemistry and Biological Activities
- Antimicrobial agents and applications
Ministry of Defence
2010-2022
Leiden University
1998-2021
Netherlands Organisation for Applied Scientific Research
2011
In recent years, Zr-based metal-organic frameworks (MOFs) have been developed that facilitate catalytic degradation of toxic organophosphate agents, such as chemical warfare agents (CWAs). Because strict regulations, experiments using live are not possible for most laboratories and, a result, simulants used in the majority cases. Reports employ real CWAs scarce and do cover whole spectrum agents. We here present comparative study which UiO-66-NH2, NU-1000, MOF-808, PCN-777 evaluated their...
The most recent global health crisis caused by the SARS-CoV-2 outbreak and alarming use of chemical warfare agents highlight necessity to produce efficient protective clothing masks against biohazard threats. However, development a multifunctional textile is still behind supply adequate protection for public. To tackle this challenge, we designed regenerable N-chlorine based biocidal detoxifying textiles using robust zirconium metal–organic framework (MOF), UiO-66-NH2, as chlorine carrier...
Novichoks are a novel class of nerve agents (also referred to as the A-series) that were employed in several poisonings over last few years. This calls for development countermeasures can be applied protective concepts (e.g., clothing) or decontamination methods. The Zr metal-organic framework MOF-808 has recently emerged promising catalyst hydrolysis V- and G-series well their simulants. In this paper, we report detailed study degradation three Novichok by buffers with varying pH. is...
The three-dimensional (3D) microporous titanium aminoterephthalate MIL-125-NH2 (MIL: Material of Institut Lavoisier) was successfully isolated as monodispersed nanoparticles, which are compatible with intravenous administration, by using a simple, safe and low-cost synthetic approach (100 °C/32 h under atmospheric pressure) so that for the first time it could be considered encapsulation release drugs. nerve agent antidote 2-[(hydroxyimino)methyl]-1-methyl-pyridinium chloride (2-PAM or...
Virucidal activity of immobilized quaternary ammonium compounds (IQACs) coated onto glass and plastic surfaces was tested against enveloped influenza A (H1N1) virus nonenveloped poliovirus Sabin1. The IQACs were virucidal the within 2 min, but no effect found in 6 h.
In the case of an incident with nerve agents, timely and ready detection identification such a substance on suspected surfaces is essential. However, low levels agents surface considerable challenge for conventional equipment, especially VX, highly toxic agent volatility. Here, we report development metal–organic framework (MOF)/fabric composite that gives rapid, visual, sensitive color response when pre-wetted rubbed over VX-contaminated surface. The fabric composed cotton textile modified...
Nerve agents are among the most toxic substances known to man. Recent events in Syria, Malaysia, and UK illustrate that threat of these is real actual. The timely detection identification nerve great importance facilitate decontamination or medical countermeasures. In this work, an effective sensitive system, based on metal–organic framework (MOF) NU-1000, was developed for disclosure V-agents, a class very persistent, highly toxic, difficult detect. NU-1000 zirconium-based MOF can hydrolyze...
Organophosphorus nerve agents (OPNAs) are highly toxic compounds inhibiting cholinergic enzymes in the central and autonomic nervous systems neuromuscular junctions, causing severe intoxications humans. Medical countermeasures efficient decontamination solutions needed to counteract toxicity of a wide spectrum harmful OPNAs including G, V Novichok agents. Here, we describe use engineered OPNA-degrading for degradation various insecticides, series OPNA surrogates, as well real chemical...
In the present work, we performed docking and molecular dynamics simulations studies on two groups of long-tailored oximes designed as peripheral site binders acetylcholinesterase (AChE) potential penetrators blood brain barrier. Our permitted to determine how tails anchor in sarin-inhibited human AChE, which aminoacids are important their stabilization. Also energy values obtained corroborated quite well with experimental results before for these oximes.
TMSOTf-mediated condensation of ethyl 4,6-O-benzylidene-1-thio-β-D-glucopyranoside (2) with peracetylated α-L-rhamnopyranosyl trichloroacetimidate donor 3a resulted in the formation orthoester 4, which, after acetylation, rearranged into 3-O-(α-L-rhamnopyranosyl)-1-thio-β-D-glucopyranoside derivative 6a. The latter compound was converted corresponding donors 8a–b. An alternative approach to 8c commenced iodonium ion mediated glycosidation 2,3,4-tri-O-benzoyl-1-thio-α-L-rhamnopyranside (15)...
In this study a systematic approach was chosen to test and characterize amine systems for CO2 capture. Vapour-liquid-equilibrium measurements were performed on homologue series of amines, with ethylene as base structure. Various functional groups used that ranged in chemical physical properties. The effect the addition following investigated: -NH2 (ethylene diamine), -COOH (s-alanine), -SH (cysteamine), SO3H (taurine) -OH (monoethanolamine). Of these systems, MEA taurine showed comparable...
A solution-phase synthesis protocol amenable to scale-up was developed for the preparation of oligonucleotides employing phosphoramidite chemistry and DMTr/iBu/Bz-protected monomers. Isolation intermediates accomplished by means extractions as only purification tool. The potential method is demonstrated with a hexameric DNA fragment in high yield purity.
We report the synthesis of novel artificial ribonucleases with potentially improved cellular uptake. The design trifunctional conjugates 1a and 1b is based on specific RNA-recognizing properties PNA, RNA-cleaving abilities diethylenetriamine (DETA), peptide (KFF)3K for potential uptake into E. coli. were assembled in a convergent synthetic route involving native chemical ligation containing an N-terminal cysteine, C-terminal thioester cell-penetrating to give 12a 12b. These hybrids contained...
Recently, a new class of reactivators chemical warfare agent inhibited acetylcholinesterase (AChE) with promising in vitro potential was developed by the covalent linkage an oxime nucleophile and peripheral site ligand. However, complexity these molecular structures thwarts their accessibility. We report compatibility various oxime-based compounds use Ugi multicomponent reaction which four readily accessible building blocks are mixed together to form product that links reactivating unit A...
Metal-organic frameworks (MOFs) are a class of porous organic-inorganic solids extensively explored for numerous applications owing to their catalytic activity and high surface area. In this work MOF thin films deposited in one-step, molecular layer deposition (MLD), an all-gas-phase process, on glass wool fibers characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, capabilities towards toxic industrial chemical (TIC) capture warfare...
The development of materials that enable the efficient removal toxic compounds is important for improvement current protective or decontamination technologies. Current rely either on agent by adsorption effecting (catalytic) degradation. Ideally, both these mechanisms are combined in a single material order to target more broad spectrum agents and improve performance materials. Recent attempts combine with adsorptive catalytic properties into composite promising, although overall often...