A5080066145- 3D Printing in Biomedical Research
- Advanced X-ray and CT Imaging
- Bone health and osteoporosis research
- Orthopaedic implants and arthroplasty
- Medical Imaging Techniques and Applications
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Additive Manufacturing and 3D Printing Technologies
- Advanced Neuroimaging Techniques and Applications
- Elasticity and Material Modeling
- Bone fractures and treatments
- Knee injuries and reconstruction techniques
- Advanced MRI Techniques and Applications
- Composite Material Mechanics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Anatomy and Medical Technology
- Orthopedic Surgery and Rehabilitation
- Titanium Alloys Microstructure and Properties
- Wireless Body Area Networks
- Facial Trauma and Fracture Management
- Nanofabrication and Lithography Techniques
- Infrared Thermography in Medicine
- Electromagnetic Fields and Biological Effects
- Hydrogels: synthesis, properties, applications
- Geophysical Methods and Applications
The University of Melbourne
2016-2023
Austrian Federal Railways
2023
St Vincent's Hospital
2017-2022
Melbourne Clinic
2018
Australian Institute for Musculoskeletal Science
2016-2017
Sunshine Hospital
2017
TU Wien
2013-2016
Articular cartilage injuries experienced at an early age can lead to the development of osteoarthritis later in life. In situ three-dimensional (3D) printing is exciting and innovative biofabrication technology that enables surgeon deliver tissue-engineering techniques time location need. We have created a hand-held 3D device (biopen) allows simultaneous coaxial extrusion bioscaffold cultured cells directly into defect vivo single-session surgery. This pilot study assessed ability biopen...
Three-dimensional (3D) bioprinting is driving major innovations in the area of cartilage tissue engineering. Extrusion-based 3D necessitates a phase change from liquid bioink to semi-solid crosslinked network achieved by photo-initiated free radical polymerization reaction that known be cytotoxic. Therefore, choice photocuring conditions has carefully addressed generate structure stiff enough withstand forces phisiologically applied on articular cartilage, while ensuring adequate cell...
Photo-crosslinkable hydrogels, in particular gelatin methacryloyl (GelMa), are gaining increasing importance biofabrication and tissue engineering. While GelMa is often described as mechanically 'tunable', clear relationships linking the photocrosslinking conditions to reaction rates, resulting mechanical properties, have not been described. Meanwhile employed literature disparate, difficult compare. In this work, situ rheological measurements were used quantify relative rate of hydrogels...
Cartilage injuries cause pain and loss of function, if severe may result in osteoarthritis (OA). 3D bioprinting is now a tangible option for the delivery bioscaffolds capable regenerating deficient cartilage tissue. Our team has developed handheld device, Biopen, to allow situ additive manufacturing during surgery. Given its ability extrude core/shell manner, Biopen can preserve cell viability biofabrication process, it currently only tool tested as surgical instrument sheep model using...
While micro-FE simulations have become a standard tool in computational biomechanics, the choice of appropriate material properties is still relevant topic, typically involving empirical grey value-to-elastic modulus relations. We here derive voxel-specific volume fractions mineral, collagen, and water, from tissue-independent bilinear relations between mineral collagen content extracellular bone tissue (J. Theor. Biol. 287: 115, 2011), measured X-ray attenuation information quantified terms...
While in clinical settings, bone mineral density measured by computed tomography (CT) remains the key indicator for fracture risk, there is an ongoing quest more engineering mechanics-based approaches safety analyses of skeleton. This calls determination suitable material properties from respective CT data, where traditional approach consists regression between attenuation-related grey values and mechanical properties. We here present a physics-oriented approach, considering that elasticity...
In this paper, a comprehensive framework is proposed to estimate the anisotropic permeability matrix in trabecular bone specimens based on micro-computed tomography (microCT) imaging combined with pore-scale fluid dynamics simulations. Two essential steps methodology are selection of (i) representative volume element (RVE) for calculation and (ii) converged mesh accurate pore flow properties. Accurate estimates porosities obtained using microCT image resolution approximately 10 μm. We show...
3D printing is a rapid and accessible fabrication technology that engenders creative custom design solutions for cell scaffolds, perfusion systems culture tissue engineering. Critical to its success the biocompatibility of materials used, which should allow long-term without affecting viability or inducing an inflammatory response in vitro vivo applications. Polyjet printers offer arguably highest resolution with fewest constraints any commercially available systems. Although widely used...
For decades, the study of tissue-engineered skeletal muscle has been driven by a clinical need to treat neuromuscular diseases and volumetric loss. The in vitro fabrication offers opportunity test drug-and cell-based therapies, disease processes, perhaps, one day, serve as graft for reconstructive surgery. This developed biofabrication technique engineer research applications. A bioprinting protocol was established deliver primary mouse myoblasts gelatin methacryloyl (GelMA) bioink, which...
Summary In this paper, an efficient numerical method is proposed to calculate the anisotropic permeability in porous materials characterized by a periodic microstructure. This based on pore‐scale fluid dynamic simulations using static volume of method. Unlike standard solution procedures for type problem, we here solve average constitutive equation over both and solid domain use subgrid model accurately capture momentum transfer from interface regions. Using arrays spheres, first demonstrate...
Due to its high resolution, micro-CT (Computed Tomograph) scanning is the key assess bone quality of sham and OVX (ovariectomized) rats. Combination basic X-ray physics, such as energy- chemistry-dependence attenuation coefficients, with results from ashing tests on rat bones, delivers mineral, organic, water volume fractions within voxels. Additional use a microelastic model for provides voxel-specific elastic properties. The new method realistic mass densities, reveals that protocols may...
Bone tumours must be surgically excised in one piece with a margin of healthy tissue. The unique nature each bone tumour case is well suited to the use patient-specific implants, additive manufacturing allowing production highly complex geometries. This work represents first assessment combination surgical robotics and additively manufactured implants.The development evaluation robotic system for excision, capable milling osteotomy paths, described. developed was evaluated as part an animal...
Drainage pipes in tunnels are very complicated to service but still need rather frequent inspections order detect the initiation of deposited scales stemming from carbonate that tends precipitate when pH-value mountain water rises with release gaseous carbon dioxide CO2 due a decreasing pressure. The drainages enable design without resistance ground We present development robot able autonomously navigate through tunnel drainage pipe systems inspecting for these scale deposits, and can...
Pulsed electromagnetic field (PEMF) stimulation has been utilized in the medical since early 20th century. A number of therapeutic devices have developed for treatment bone fractures and other applications. Most these are backed by limited quantitative evidence. In this paper we present development a PEMF device purposes determining, through vitro experimentation, exposure parameters required to give most optimal fracture repair. Following characterization, was shown match well with...