A5063647356- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Elasticity and Material Modeling
- Bone health and treatments
- Cellular Mechanics and Interactions
- Scoliosis diagnosis and treatment
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Medical Imaging and Analysis
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Spinal Fractures and Fixation Techniques
- Shoulder and Clavicle Injuries
- Hip disorders and treatments
- Bone and Joint Diseases
- Knee injuries and reconstruction techniques
- Soil and Unsaturated Flow
- Spine and Intervertebral Disc Pathology
- Lower Extremity Biomechanics and Pathologies
- Musculoskeletal pain and rehabilitation
- Medical Imaging Techniques and Applications
- Electrostatics and Colloid Interactions
- Alkaline Phosphatase Research Studies
- Landfill Environmental Impact Studies
Queensland University of Technology
2017-2025
Philadelphia University
2023
Australian Institute for Musculoskeletal Science
2013-2022
The University of Melbourne
2008-2022
Mater Health Services
2020
Sunshine Hospital
2017
St Vincent's Hospital
2017
Melbourne Clinic
2017
The University of Western Australia
2009-2016
Australian Institute of Music
2014
Articular cartilage injuries experienced at an early age can lead to the development of osteoarthritis later in life. In situ three-dimensional (3D) printing is exciting and innovative biofabrication technology that enables surgeon deliver tissue-engineering techniques time location need. We have created a hand-held 3D device (biopen) allows simultaneous coaxial extrusion bioscaffold cultured cells directly into defect vivo single-session surgery. This pilot study assessed ability biopen...
Three-dimensional (3D) bioprinting is driving major innovations in the area of cartilage tissue engineering. Extrusion-based 3D necessitates a phase change from liquid bioink to semi-solid crosslinked network achieved by photo-initiated free radical polymerization reaction that known be cytotoxic. Therefore, choice photocuring conditions has carefully addressed generate structure stiff enough withstand forces phisiologically applied on articular cartilage, while ensuring adequate cell...
Bone remodeling is a process involving removal of mature bone tissue and subsequent formation new tissue. This driven by complex actions biological cells biochemical factors, it sensitive to the loads applied onto skeleton. Herein, we develop mathematical framework describing this at (macroscopic) level cortical bone, combining, for first time, cell population kinetics with multiscale mechanics. Key variables are concentrations (osteoclasts, osteoblasts their progenitors) factors (RANK,...
Mechanical loads which are macroscopically acting onto bony organs, known to influence the activities of biological cells located in pore spaces bone, particular so signaling and production processes mediated by osteocytes. The exact mechanisms osteocytes actually able “feel” mechanical loading changes thereof, has been subject numerous studies, and, while several hypotheses have brought forth over time, this topic remained a matter debate. Relaxation times reported recent experimental study...
The lacunar-canalicular network (LCN) of bone contains osteocytes and their dendritic extensions, which allow for intercellular communication, are believed to serve as the mechanosensors that coordinate processes modeling remodeling. Imbalances in remodeling, example, linked disease, including fragility associated with aging. We have reported there is a reduction scale one component LCN, osteocyte lacunar volume, across human lifespan females. In present study, we explore hypothesis...
In spine research, two possibilities to generate models exist: generic (population-based) representing the average human and subject-specific representations of individuals. Despite increasing interest in subject specificity, individualisation remains challenging. Neuro-musculoskeletal (NMS) enable analysis prediction dynamic motions by incorporating active muscles attaching bones that are connected using articulating joints under assumption rigid body dynamics. this study, we used...
Osteoporosis (OP) is a chronic progressive bone disease which characterised by reduction of matrix volume and changes in the properties can ultimately lead to fracture. The two major forms OP are related aging and/or menopause. With worldwide increase elderly population, particularly age-related poses serious health issue puts large pressure on care systems. A challenge for development new drug treatments comparison efficacy with existing due current regulatory requirements demand testing...
We explored the integration of 3D ultrasound (US) imaging with motion capture technology for non-invasively tracking bones shoulder district during normal activity. Our study aimed to demonstrate ex-vivo proposed US method's feasibility and accuracy in a controlled cadaveric positioned various arm elevations (low, mid high). registered previously acquired full bone shapes spatially small bony surface patches segmented from US. The registration approach used was based on silico analyses that...
Abstract Recent advancements in deep learning have significantly enhanced the segmentation of high-resolution microcomputed tomography (µCT) bone scans. In this paper, we present dual-branch attention-based hybrid network (DBAHNet), a architecture designed for automatically segmenting cortical and trabecular compartments 3D µCT scans mouse tibiae. DBAHNet’s hierarchical structure combines transformers convolutional neural networks to capture long-range dependencies local features improved...
An emerging alternative to conventional piezoelectric technologies, which continue dominate the ultrasound medical imaging (US) market, is Capacitive Micromachined Ultrasonic Transducers (CMUTs). Ultrasound transducers based on this technology offer a wider frequency bandwidth, improved cost-effectiveness, miniaturized size and effective integration with electronics. These features have led an increase in commercialization of CMUTs last 10 years. We conducted review answer three main...
Purpose: The aim of this study was to investigate the application three-dimensional bone bioreactor for studying drug-release kinetics and distribution drugs in ex vivo cancellous environment, demonstrate nanoengineered titanium (Ti) wires generated with titania nanotube (TNT) arrays as drug-releasing implants local drug delivery Methods: Nanoengineered Ti covered a layer TNT implanted were used implant. Viable bovine trabecular substrate embedded placed reactor. A hydrophilic fluorescent...