A5045657016- Peroxisome Proliferator-Activated Receptors
- Electron Spin Resonance Studies
- RNA modifications and cancer
- Photochemistry and Electron Transfer Studies
- Spectroscopy and Quantum Chemical Studies
- Photosynthetic Processes and Mechanisms
- RNA Research and Splicing
- Molecular Sensors and Ion Detection
- RNA and protein synthesis mechanisms
- Advanced Biosensing Techniques and Applications
- Signaling Pathways in Disease
- Antibiotics Pharmacokinetics and Efficacy
- Various Chemistry Research Topics
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
University of Münster
2022-2023
Ruhr University Bochum
2021
Although it is well-known that limited local mutations of enzymes, such as matrix metalloproteinases (MMPs), may change enzyme activity by orders magnitude well its stability, the completely rational design proteins still challenging. These changes alter electrostatic potential and thus fields, which impacts dynamics water molecules close protein surface. Here we show a combined computational design, experimental, molecular (MD) study have not only but also global effect on solvent: In...
The properties of the water network in concentrated HCl acid pools nanometer-sized reverse nonionic micelles were probed with TeraHertz absorption, dielectric relaxation spectroscopy, and reactive force field simulations capable describing proton hopping mechanisms. We identify that only at a critical micelle size W0 =9 do solvated complexes form pool, accompanied by change mechanism from Grotthuss forward shuttling to one favors local oscillatory hopping. This is due preference for H+ Cl-...
The double-ring AAA+ ATPase Pex1/Pex6 is required for peroxisomal receptor recycling and essential peroxisome formation. mutations cause severe associated developmental disorders. Despite its pathophysiological importance, mechanistic details of the heterohexamer are not yet available. Here, we report cryoEM structures from Saccharomyces cerevisiae, with an endogenous protein substrate trapped in central pore catalytically active second ring (D2). Pairs Pex1/Pex6(D2) subdomains engage via a...
Abstract The properties of the water network in concentrated HCl acid pools nanometer‐sized reverse nonionic micelles were probed with TeraHertz absorption, dielectric relaxation spectroscopy, and reactive force field simulations capable describing proton hopping mechanisms. We identify that only at a critical micelle size W 0 =9 do solvated complexes form pool, accompanied by change mechanism from Grotthuss forward shuttling to one favors local oscillatory hopping. This is due preference...
Abstract The double-ring AAA+ ATPase Pex1/Pex6 is required for peroxisomal receptor recycling and essential peroxisome formation. mutations cause severe associated developmental disorders. Despite its pathophysiological importance, mechanistic details of the heterohexamer are not yet available. Here, we report cryoEM structures from Saccharomyces cerevisiae , with an endogenous protein substrate trapped in central pore second ring (D2). Pairs Pex1/Pex6(D2) subdomains engage via a staircase...
Protonen , die in nichtionischen reversen Mizellen eingeschlossen sind, erfahren einen “Stau”, bei dem das Vorwärts-Hopping von – der Grotthuss-Mechanismus eingeschränkt ist. Dieser Effekt ist größen- und konzentrationsabhängig: In kleinen oder niedrigeren Konzentrationen diffundieren frei durch Vorwärts-Hopping. größeren höheren sammeln sich Ionen an Grenzfläche Mizelle verursachen Stau, verfügbaren Wege für Bewegung Wasserinnere beschränkt, wie Martina Havenith, Teresa Head-Gordon et al....