A5027440523- Nail Diseases and Treatments
- Fungal Infections and Studies
- Plant Pathogens and Fungal Diseases
- Cutaneous lymphoproliferative disorders research
- Infectious Diseases and Mycology
- Dermatologic Treatments and Research
- Bee Products Chemical Analysis
- Bacterial Identification and Susceptibility Testing
- Hair Growth and Disorders
- Streptococcal Infections and Treatments
- Otolaryngology and Infectious Diseases
- Cutaneous Melanoma Detection and Management
- Mycobacterium research and diagnosis
- Ocular Oncology and Treatments
- Autoimmune Bullous Skin Diseases
- melanin and skin pigmentation
- Actinomycetales infections and treatment
Teikyo University
2016-2023
Teikyo University Hospital, Mizonokuchi
2021
Japanese Society of Medical Oncology
2018-2019
Teikyo University Hospital
2016
Abstract The “Guidelines for the management of dermatomycosis” Japanese Dermatological Association were first published in 2009 and Guidelines Committee revised it 2019. guidelines was prepared according to opinions members educational value. version is composed introductory descriptions disease concepts, diagnosis, medical mycology recent advances treatment, along with clinical questions (CQ), which intended help general practice dermatologists. CQ are limited those involved therapy but...
Abstract We evaluated the efficacy of efinaconazole 10% topical solution in long‐term use, for up to 72 weeks, onychomycosis, including severe cases. Among 605 participants, 219 patients diagnosed as having onychomycosis were efinaconazole. The treatment success rate (<10% clinical involvement target toenail) at final assessment time point was 56.6%, complete cure 31.1% and mycological 61.6%, all which increased over time, demonstrating that continuous application contributed improvement...
Topical or systemic antifungal therapy was administered to patients diagnosed with Malassezia folliculitis during the 5-year period between March 2007 and October 2013. The diagnosis of established on basis characteristic clinical features direct microscopic findings (10 more yeast-like fungi per follicle). Treatment consisted topical application 2% ketoconazole cream 100 mg oral itraconazole based symptom severity patients' preferences. given until papules flattened, flat were examined...
Abstract In Japan, an epidemiological survey of onychomycosis pathogens was performed using culture methods; however, the positive rate 40% or less. As part dermatomycoses in we overcame this low by employing a real-time polymerase chain reaction (PCR) assay that allowed rapid and accurate detection identification. 2011, nail specimens were collected from patients at nine institutes various prefectures Japan diagnosed as onychomycosis. For identification main causing onychomycosis, PCR...
Many clinicians prefer to treat onychomycosis systemically. However, systemic therapy may not be suitable for all patients due drug interactions, side effects of oral medications, or comorbidities. Two topical agents (efinaconazole 10% in 2014 and luliconazole 5% 2016) have recently been approved treatment Japan. We investigated the efficacy these at Teikyo University Mizonokuchi Hospital, Kanagawa, conducted a retrospective survey among diagnosed with our outpatient clinic had treated...
A 41-year-old man visited our dermatology clinic because an eruption, which was resistant to steroid ointment treatment, had appeared on his right forearm. An oval, soybean-sized erythematous infiltrated lesion with scales and crusts located in the central part of extensor surface forearm showed partial erosion attached yellow crusts. The impetigo-like appearance. Fungal elements were confirmed from by KOH examination fungus identified as Trichophyton tonsurans fungal culture molecular...
Onychomycosis with longitudinal spikes in the nail plate has been reported to be refractory oral drugs as dermatophytoma. We evaluated efficacy of 10% efinaconazole solution treatment onychomycosis spikes. Of 223 subjects who were enrolled a previous study, post-hoc analysis 82 was performed this study. The opacity ratio decreased over time from 8.1 0.9 at final assessment. In addition, spike disappearance rate increased early after application 81.7% Therefore, can first-line drug for...
A 64-year-old woman presented with a fist-sized, severely painful lesion scales, crusts, pustules, erythema subcutaneous abscess, and hair loss on the left temporal region. Direct microscopic examination revealed large number of spores around hair, which indicated ectothrix invasion, some hyphae were also found. Histopathological showed significant inflammatory cell infiltration from dermis to tissues into follicles, destruction follicles granulomatous reactions, fungal masses along within...
20 歳，女性。小児期より認めた右上眼瞼の色素斑が数年前より増大，隆起してきた。長径 7 mm の青黒色隆起性結節で，病理組織学的に青色母斑の所見に加え，表皮下層部に dendritic melanocyte が認められ，‘compound’ blue nevus と診断した。Compound は極めてまれな腫瘍で，結節型悪性黒色腫と誤診されることがあり，注意を要する。
Abstract Fosravuconazole L-lysine ethanolate (F-RVCZ), a ravuconazole prodrug, is newly available agent with high expectations for efficacy in the treatment of onychomycosis. However, clinical data regarding F-RVCZ are limited because drug was launched only Japan 2018. Therefore, we analyzed outcome therapy onychomycosis at outpatient dermatology clinics Japan. We examined 109 patients (68 male, 41 female) varying type, including total dystrophic and dermatophytoma, wide range age groups,...