A5077504586- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Surgical Treatments
- Thyroid Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Colorectal and Anal Carcinomas
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- Pituitary Gland Disorders and Treatments
- Gastric Cancer Management and Outcomes
- Hernia repair and management
- Multiple and Secondary Primary Cancers
- Thyroid and Parathyroid Surgery
- Urticaria and Related Conditions
- Management of metastatic bone disease
- Genetic Neurodegenerative Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Psoriasis: Treatment and Pathogenesis
- Cancer-related Molecular Pathways
- Colorectal Cancer Treatments and Studies
- Congenital Diaphragmatic Hernia Studies
- Parathyroid Disorders and Treatments
- Airway Management and Intubation Techniques
- Head and Neck Anomalies
Sapienza University of Rome
2016-2025
Policlinico Umberto I
2016
The new Italian cytological classification (2014) of thyroid nodules replaced the TIR3 category old (2007) with two subclasses, TIR3A and TIR3B, aim reducing rate surgery for benign diseases. Moreover, imaging reporting data system (TI-RADS) score appears to ameliorate stratification malignancy risk. We evaluated whether has improved diagnostic accuracy its association TI-RADS could improve prediction. retrospectively analyzed 70 from patients classified as according who underwent...
The dysregulation of PD-1 ligands (PD-L1 and PD-L2) CTLA-4 (CD80 CD86) represents a tumor strategy to escape the immune surveillance. Here, expression PD-L1 , PD-L2 CD80 CD86 was evaluated at mRNA level in 94 patients affected by papillary thyroid carcinoma (PTC) 11 anaplastic (ATC). Variations mRNAs PTC were then correlated with clinicopathological features. all genes deregulated ATC tissues compared normal tissues. In particular, downregulation observed above ATC. addition, increased...
The transcription factors involved in epithelial–mesenchymal transition (EMT-TFs) silence the genes expressed epithelial cells (e.g., E-cadherin) while inducing those typical of mesenchymal vimentin). core set EMT-TFs comprises Zeb1, Zeb2, Snail1, Snail2, and Twist1. To date, information concerning their expression profile clinical utility during thyroid cancer (TC) progression is still incomplete. We evaluated EMT-TF, E-cadherin, vimentin mRNA levels 95 papillary TC (PTC) 12 anaplastic...
Multisystem inflammatory syndrome in children (MIS-C) is a rare hyperinflammatory disease occurring several weeks after SARS-CoV-2 infection. The clinical similarities between MIS-C and the toxic shock syndrome, together with preferential expansion of T cells T-cell receptor variable β chain (TCRVβ) skewing, suggested superantigen theory MIS-C. For instance, recent silico modelling evidenced presence highly conserved motif within spike protein similar structure to superantigenic fragment...
Thyroidectomy performed by an experienced surgeon is associated with a low incidence of recurrent laryngeal nerve injury and permanent hypoparathyroidism. During reoperative thyroid surgery there higher technical risk because detection preservation the nerves parathyroid glands are more difficult than in primary surgery.Our retrospective cohort study was to assess short- long-term complications order suggest approach lower morbidity rate.From January 2005 September 2013, 745 patients...
CD28 is an important costimulatory receptor for T lymphocytes that, in humans, delivers TCR-independent signal leading to the up-regulation of pro-inflammatory cytokines. We have recently reported that autonomous signalling induces expression IL-17A peripheral CD4+ from healthy donors, multiple sclerosis and type 1 diabetes patients. Due relevance pathophysiology several inflammatory autoimmune diseases, we characterized mechanisms mediators responsible CD28-induced expression. Here show...
Oesophageal leiomyoma is the most common benign tumour of oesophagus. The incidence leiomyomas larger than 10 cm, defined as giant oesophageal (GELs), has been reported in 17% all cases. Although computed tomographic scan and endoscopy are usually useful for diagnosis, big symptomatic masses located lower mediastinum remain both a diagnostic therapeutic challenge.We describe our experience management 7 patients (4 males 3 females, with mean age 41 years) GEL treated department. Radical...
About 5% of occult gastrointestinal bleeding derives from small intestinal lesions. The intraoperative enteroscopy (IOE), although the development double-balloon and capsule endoscopy reduced indications, is still valid to locate site in some selected cases. An 88-year-old woman presenting emergency department with a severe anemia underwent laparotomic exploration IOE. A 15-mm laparoscopy trocar sterile camera drape was adopted introduce standard colonoscope through an enterotomy. operation...
Establishment and maintenance of the apical-basal cell polarity, required for proper replication, migration, specialized functions tissue morphogenesis, relies on three evolutionary conserved complexes: PAR, CRUMBS SCRIBBLE. Loss polarity/cohesiveness (LOP/C) is implicated in cancer progression, members polarity complex have been described as either oncogenes or oncosuppressors. However, no information their role thyroid (TC) progression available. In present study, we evaluated gene...
IL-22 is a member of the IL-10 cytokine family involved in host protection against extracellular pathogens, by promoting epithelial cell regeneration and barrier functions. Dysregulation production has also frequently been observed acute respiratory distress syndrome (ARDS) several chronic inflammatory autoimmune diseases. We have previously described that human CD28, crucial co-stimulatory receptor necessary for full T activation, able to act as TCR independent signaling induce expression...