A5049143174- Vector-borne infectious diseases
- Insect and Pesticide Research
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Yersinia bacterium, plague, ectoparasites research
- Insect symbiosis and bacterial influences
- Mosquito-borne diseases and control
University of Neuchâtel
2016-2023
ABSTRACT Mixed or multiple-strain infections are common in vector-borne diseases and have important implications for the epidemiology of these pathogens. Previous studies mainly focused on interactions between pathogen strains vertebrate host, but little is known about what happens arthropod vector. Borrelia afzelii garinii two species spirochete bacteria that cause Lyme borreliosis Europe share a tick vector, Ixodes ricinus . Each tick-borne pathogens consists multiple often differentiated...
The population dynamics of vector-borne pathogens inside the arthropod vector can have important consequences for vector-to-host transmission. Tick-borne spirochete bacteria Borrelia burgdorferi (sensu lato) species complex cause Lyme borreliosis in humans and spend long periods time (>12 months) their Ixodes tick vectors. To date, few studies investigated populations unfed nymphal ticks. Larval ticks from our laboratory colony I. ricinus were experimentally infected with B. afzelii, killed...
Multistrain microbial pathogens often induce strain-specific antibody responses in their vertebrate hosts. Mothers can transmit antibodies to offspring, which provide short-term, protection against infection. Few experimental studies have investigated this phenomenon for multiple strains of zoonotic occurring wildlife reservoir The tick-borne bacterium Borrelia afzelii causes Lyme disease Europe and consists that cycle between the tick vector (Ixodes ricinus) hosts, such as bank vole (Myodes...
Abstract The spirochete bacterium Borrelia afzelii is the most common cause of Lyme borreliosis in Europe. This tick-borne pathogen can establish systemic infections rodents but not birds. However, several field studies have recovered larval Ixodes ricinus ticks infected with B. from songbirds suggesting successful transmission . We reviewed literature to determine which songbird species were frequent carriers -infected I. larvae and nymphs. tested experimentally whether capable co-feeding...
Multiple-strain pathogens often establish mixed infections inside the host that result in competition between strains. In vector-borne pathogens, competitive ability of strains must be measured both vertebrate and arthropod vector to understand outcome competition. Such studies could reveal existence trade-offs different types. We used tick-borne bacterium Borrelia afzelii test for rodent tick vector, a trade-off these two Mice were infected via bite with either one or strains, mice...
Abstract The study of polymorphic immune genes in host populations is critical for understanding genetic variation susceptibility to pathogens. Controlled infection experiments are necessary separate the probability exposure from infection, but such rare wild vertebrate reservoir hosts and their zoonotic bank vole ( Myodes glareolus ) an important Borrelia afzelii , a tick-borne spirochete that causes Lyme disease. Bank Toll-like receptor 2 (TLR2), innate recognizes bacterial lipoproteins....
Vector-borne pathogens often consist of genetically distinct strains that can establish co-infections in the vertebrate host and arthropod vector. Co-infections (or mixed infections) result competitive interactions between with important consequences for strain abundance transmission. Here we used spirochete bacterium, Borrelia afzelii, as a model system to investigate inside its tick vector, Ixodes ricinus. Larvae were fed on mice infected either one or two B. afzelii. Engorged larvae...
Abstract Pathogen species often consist of genetically distinct strains, which can establish mixed infections or coinfections in the host. In coinfections, interactions between pathogen strains have important consequences for their transmission success. We used tick-borne bacterium Borrelia afzelii, is most common cause Lyme disease Europe, as a model multi-strain to investigate relationship coinfection, competition and strain-specific Mus musculus mice were infected with one two B. strain...
Many vector-borne pathogens establish multiple-strain infections in the vertebrate host and arthropod vector. Multiple-strain influence strain acquisition by naive vectors. Whether vector strain-specific transmission to hosts remains unknown. The spirochete, Borrelia afzelii, causes Lyme borreliosis are common both tick host. Our study used two B. afzelii strains: Fin-Jyv-A3 NE4049. Donor mice were infected with alone, NE4049 or strains. Larval ticks fed on donor molted into nymphal either...
Abstract The vertebrate immune system can produce antibodies that protect the host against pathogens. Females transmit to their offspring, which provide short-term protection infection. tick-borne bacterium Borrelia afzelii causes Lyme disease in Europe and consists of multiple strains cycle between tick vector ( Ixodes ricinus ) hosts such as bank vole Myodes glareolus ). We used a controlled experiment show infected female voles protective offspring are specific for strain B. . To test...