A5046669174- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Insect and Pesticide Research
- Viral Infections and Vectors
- Insect symbiosis and bacterial influences
- Immune Cell Function and Interaction
- Vector-Borne Animal Diseases
- Toxoplasma gondii Research Studies
- IL-33, ST2, and ILC Pathways
- Herpesvirus Infections and Treatments
- Insect behavior and control techniques
- Insect Pest Control Strategies
- Yersinia bacterium, plague, ectoparasites research
- Immunodeficiency and Autoimmune Disorders
- Rabbits: Nutrition, Reproduction, Health
- Urticaria and Related Conditions
- Malaria Research and Control
- T-cell and Retrovirus Studies
- Environmental Toxicology and Ecotoxicology
- Animal Nutrition and Physiology
- Insect and Arachnid Ecology and Behavior
- Research on Leishmaniasis Studies
- Escherichia coli research studies
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
University of Pennsylvania
2019-2025
Philadelphia University
2024
University Hospital of Basel
2021-2022
University of Basel
2021-2022
University of Neuchâtel
2015-2019
California University of Pennsylvania
2019
Centre de Recherche et de Veille sur les Maladies Emergentes dans l’Océan Indien
2012
Institut de Recherche pour le Développement
2012
Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
2012
Centre National de la Recherche Scientifique
2012
Reunion Island suffers from high densities of the chikungunya and dengue vector Aedes albopictus. The sterile insect technique (SIT) offers a promising strategy for mosquito-borne diseases prevention control. For such to be effective, males need competitive enough fulfil their intended function by reducing wild mosquito populations in natura. We studied effect irradiation on sexual maturation mating success males, compared competitiveness versus presence females semi-field conditions. all...
Mucosal-associated invariant T (MAIT) cells are the most abundant in human liver. They respond to bacterial metabolites presented by major histocompatibility complex-like molecule MR1. MAIT exert regulatory and antimicrobial functions implicated liver fibrogenesis. It is not well understood which function as antigen (Ag)-presenting for cells, under conditions stimulatory Ags reach circulation.We used different types of primary Ag-presentation assays blood-derived liver-derived cells. We...
Studies on the biology and mating behaviour of male mosquitoes are major importance in a frame Sterile Insect Technique which could be used against mosquito vector species. Most particularly, assumption possible multiple inseminations species must investigated order to optimize alternative control methods (Sterile Techniques with genetically modified mosquitoes, cytoplasmic incompatibility, radiation…). The occurrence insemination events was after 2 field samplings Aedes albopictus (Diptera:...
ABSTRACT Many vector-borne pathogens consist of multiple strains that circulate in both the vertebrate host and arthropod vector. Characterization community pathogen vector is therefore important for understanding epidemiology mixed infections. Borrelia afzelii B. garinii are two species tick-borne bacteria cause Lyme disease humans. These sympatric use same tick, Ixodes ricinus , but adapted to different classes hosts. Both classified using highly polymorphic ospC gene. Vertebrate...
IL-33 is an alarmin required for resistance to the parasite Toxoplasma gondii , but its role in innate this organism unclear. Infection with T. promotes increased stromal cell expression of IL-33, and levels replication correlate release affected tissues. In response infection, a subset lymphoid cells (ILC) emerges composed IL-33R + NK ILC1s. Rag1 −/− mice, where ILC1 production IFN-γ mediate loss resulted reduced ILC responses replication. Furthermore, administration mice marked decrease...
Latency is a microbial strategy for persistence. For Toxoplasma gondii the bradyzoite stage forms long-lived cysts critical transmission, and its presence in neurons considered important immune evasion. However, extent to which cyst formation escapes pressure mediates persistence remained unclear. Here we developed mathematical model highlighting that bradyzoite-directed immunity contributes control of numbers. In vivo studies demonstrated transgenic CD8+ T cells recognized cyst-derived...
The population dynamics of vector-borne pathogens inside the arthropod vector can have important consequences for vector-to-host transmission. Tick-borne spirochete bacteria Borrelia burgdorferi (sensu lato) species complex cause Lyme borreliosis in humans and spend long periods time (>12 months) their Ixodes tick vectors. To date, few studies investigated populations unfed nymphal ticks. Larval ticks from our laboratory colony I. ricinus were experimentally infected with B. afzelii, killed...
Transmission from the vertebrate host to arthropod vector is a critical step in life-cycle of any vector-borne pathogen. How probability host-to-vector transmission changes over duration infection an important predictor pathogen fitness. The Lyme disease Borrelia afzelii transmitted by Ixodes ricinus ticks and establishes chronic inside rodent reservoir hosts. present study compares temporal pattern host-to-tick between two strains B. afzelii. Laboratory mice were experimentally infected via...
Multistrain microbial pathogens often induce strain-specific antibody responses in their vertebrate hosts. Mothers can transmit antibodies to offspring, which provide short-term, protection against infection. Few experimental studies have investigated this phenomenon for multiple strains of zoonotic occurring wildlife reservoir The tick-borne bacterium Borrelia afzelii causes Lyme disease Europe and consists that cycle between the tick vector (Ixodes ricinus) hosts, such as bank vole (Myodes...
The populations of many pathogen species consist a collection common and rare strains but the factors underlying this strain-specific variation in frequency are often unknown. Understanding among is particularly challenging for vector-borne pathogens where fitness depends on performance both vertebrate host arthropod vector. Two sympatric multiple-strain tick-borne pathogens, Borrelia afzelii B. garinii, that use same tick vector, Ixodes ricinus, different hosts were studied. 454-sequencing...
Summary Vector‐borne pathogens use a diversity of strategies to evade the vertebrate immune system. Co‐feeding transmission is potential evasion strategy because vector‐borne pathogen minimizes time spent in host. We tested whether Lyme disease pathogen, B orrelia afzelii , can co‐feeding escape acquired response induced strain‐specific, protective antibody by immunizing mice with one two variants OspC (A3 and A10), highly variable outer surface protein C pathogens. Immunized were challenged...
Anthropogenic disturbances are changing the geographic distribution of ticks and tick-borne diseases. Over last few decades, tick Ixodes ricinus has expanded its range abundance considerably in northern Europe. Concurrently, incidence diseases, such as Lyme borreliosis encephalitis, increased human populations Scandinavian countries. Wildlife can serve sentinels for changes We used serum samples from a long-term study on brown bear, Ursus arctos, standard immunological methods to test...
Female Aedes aegypti mosquitoes are vectors of yellow fever, dengue and chikungunya viruses. Pre-exposure Ae. larvae to the herbicide atrazine significantly reduced their sensitivity organophosphate insecticide temephos. Mosquito pre-exposed for 48 h non-lethal concentrations ranging from 1 10 μg/l commonly encountered in field, appeared slightly less sensitive temephos than non-pre-exposed larvae. The effect a pre-exposure on larval tolerance did not seem be related an induction...
Abstract Latency is a microbial strategy for persistence. For Toxoplasma gondii the ability of bradyzoite stage to form long-lived cysts critical transmission, while their presence in neurons considered important immune evasion. Development mathematical model highlighted that pressure on bradyzoites should contribute dynamics cyst formation and reactivation. Experimental data demonstrated cyst-derived antigen was recognized by CD8 + T cells IFN-γ signaling contributes control. In addition,...
Abstract The vertebrate immune system can produce antibodies that protect the host against pathogens. Females transmit to their offspring, which provide short-term protection infection. tick-borne bacterium Borrelia afzelii causes Lyme disease in Europe and consists of multiple strains cycle between tick vector ( Ixodes ricinus ) hosts such as bank vole Myodes glareolus ). We used a controlled experiment show infected female voles protective offspring are specific for strain B. . To test...