Levulinic acid is a key platform molecule derived from biomass and readily available natural sources, making it an attractive starting material for the synthesis of high-value chiral compounds. Among them, γ-valerolactone 5-methylpyrrolidin-2-one derivatives are notable their widespread occurrence biological importance. This review paper highlights importance as frameworks found in biologically active compounds pharmaceuticals. It focuses on asymmetric these building blocks levulinic acid,...

Cyclic sulfones play an important role in the field of drug discovery and design due to their valuable properties broad range applications. Herein, we report efficient cerium(IV)-catalyzed allylic oxidation a simple 3-sulfolene. This process provides straightforward facile approach sulfol-2-en-4-one, versatile synthetic intermediate. Notably, this study represents first instance cerium catalysis employed oxidation. Furthermore, demonstrated transformation sulfol-2-en-4-one into 4-substituted...

In this work, we establish quantitative structure–property relationships (QSPR) to predict the melting temperatures of diphosphine dioxides possessing a tetradecahydrophosphanthrene core, based on four two-parameter models.

Nickel-supported nanoparticles were used as catalysts for ligand-free Hirao coupling between secondary phosphine oxides and aryl halides.

This paper presents the thermal behavior of polymer microspheres based on glycidyl methacrylate (GMA) and crosslinking agents benzene-1,4-diylbis(2-methylprop-2-enoate) (1,4DMB) trimethylolpropane trimethacrylate (TRIM) before after functionalization with thioglycolic acid (TGA). The stability polymers was determined using thermogravimetric analysis differential scanning calorimetry under non-oxidizing conditions. evolved gases were detected by FTIR NMR spectroscopy, chemical structure solid...

Abstract The desymmetrization of the prochiral tetrabromobiphenyl via asymmetric bromine–lithium exchange as a key step synthesis novel biphenyl‐diphosphine ligands is reported. This new approach allows an easy access to twelve enantiomerically pure atropisomeric in one‐ three‐step reactions good excellent yields. magnified image

Thiochalcones undergo cycloaddition reactions in THF solution at 60 °C with the synthetically unexplored 1-phenyl-4

Two synthetic protocols for the conversion of 1-phenylphosphinan-4-ones to novel P-stereogenic 1-phenylphosphin-2-en-4-ones by enantioselective deprotonation followed oxidation and asymmetric organocatalytic halogenation accompanied elimination have been developed. These two-step one-pot transformations provide convenient access optically active 1-phenylphosphin-2-en-4-one 1-sulfide 1-oxide 96 55% enantiomeric purities, respectively.

1-Phenylphosphol-2-ene 1-oxide is effectively resolved by L-menthyl bromoacetate to afford both SP and RP enantiomers of 1-phenylphosphol-2-ene on a multigram scale. The oxide has been found undergo face-selective endo-selective cycloadditions with series acyclic cyclic dienes produce enantiopure P-stereogenic C-P heterocycles hexahydrophosphindole hexahydrobenzophosphindole as well phospha[5.2.1.02,6]decene phospha[5.2.2.02,6]undecene structures. Conversions these cycloadducts the fully...

α-Oxy- o-xylylene, a highly reactive diene readily accessible from benzocyclobutenol, undergoes Diels-Alder reaction with vinylphosphine oxides, yielding the corresponding 2-phosphorylated 1-hydroxy-1,2,3,4-tetrahydronaphthalenes in excellent yields. Use of unsubstituted and trans-2-aryl-substituted oxides leads to cycloadducts complete regioselectivity cis/trans selectivity up 19:1 most favorable case. In case P-stereogenic virtually chirality transfer P C can be achieved. Dehydration...

Gerty T. and Carl F. Cori discovered, during research on the metabolism of sugars in organisms, important role phosphate ester a simple sugar. Glucose molecules are released from glycogen—the glucose stored liver—in presence phosphates enter blood as α-D-glucose-1-phosphate (Glc-1PH2). Currently, crystal structure three phosphates, Glc-1PNa2·3.5·H2O, Glc-1PK2·2H2O, Glc-1PHK, is known. Research has shown that reactions Glc-1PH2 with carbonates produce new complexes ammonium ions...

Abstract Review: 49 refs.

The resolution of racemic 1-phenylphosphin-2-en-4-one 1-oxide (2), was achieved through the fractional crystallization its diastereomeric complexes with (4R,5R)-(-)-2,2-dimethyl -α,α,α',α'-tetraphenyl-dioxolan-4,5-dimethanol (R,R-TADDOL) followed by liberation individual enantiomers 2 flash chromatography on silica gel columns. process furnished two 99.1 and 99.9% e.e. at isolated yields 62 59% (counted for single enantiomer), respectively. absolute configurations were established means...

Abstract Twelve novel chiral biphenyl‐diphosphine ligands, e.g. compounds (III), (V), and (VI), are prepared starting from the common precursor (I).