A5020065865- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
- Organophosphorus compounds synthesis
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Reactions
- Extraction and Separation Processes
- Catalysis for Biomass Conversion
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis of Organic Compounds
- Redox biology and oxidative stress
- Neurotransmitter Receptor Influence on Behavior
- Enzyme Catalysis and Immobilization
- Sulfur Compounds in Biology
- Radical Photochemical Reactions
- Axial and Atropisomeric Chirality Synthesis
- Organometallic Complex Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Analytical Chemistry and Chromatography
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Chemical synthesis and alkaloids
- Molecular Sensors and Ion Detection
- Synthesis and Biological Evaluation
Maria Curie-Skłodowska University
2016-2025
Kansas State University
2021
University of Kansas Medical Center
2021
Southern University of Science and Technology
2021
Ruhr University Bochum
2021
Freie Universität Berlin
2021
Enamine (Ukraine)
2021
Institute of Organic Chemistry
2021
University of Warsaw
2017
For several decades, coumarins have attracted considerable attention due to the fact of their application in diverse fields such as medical science and biomedical research well industrial branches. Recently, many compounds containing coumarin moiety been intensively studied, mainly biological activities antitumor, antioxidative, anti-HIV, vasorelaxant, antimicrobial, anticancer. They are also widely used fluorescent dyes probes because great structural flexibility large quantum yields. this...
Levulinic acid is a key platform molecule derived from biomass and readily available natural sources, making it an attractive starting material for the synthesis of high-value chiral compounds. Among them, γ-valerolactone 5-methylpyrrolidin-2-one derivatives are notable their widespread occurrence biological importance. This review paper highlights importance as frameworks found in biologically active compounds pharmaceuticals. It focuses on asymmetric these building blocks levulinic acid,...
Abstract: Nature-derived thiols such as cysteine, homocysteine, and reduced glutathione play diverse important roles in both plant animal cells. In plants, they maintain redox homeostasis affect photosynthesis signal transduction processes. animals, changes the levels of biothiols have been linked to cardiovascular disease, Alzheimer's neuropsychiatric disorders, or stroke. The detection biological samples is, therefore, very important. For this purpose, rapid, sensitive, non-invasive...
This paper presents the general synthesis of a comprehensive group P-chiral phosphinyl derivatives with natural coumarin-type motif. A chiral substituent was attached at third position coumarin molecule via Knoevenagel procedure using readily available phoshinylacetic acid esters without loss enantiomeric purity. The application salicylaldehyde-based allowed incorporation substituents different electron character into backbone these coumarins making them suitable for subsequent chemical...
A simple, highly efficient synthesis of a series novel chiral non-racemic rigid tetracyclic phosphorus ligands, applicable in important chemical asymmetric transformations, was performed. In tandem cross-coupling/C-H bond activation reaction, well-recognised and readily available ligand (R,R)-NORPHOS used as the starting material. The palladium complexes new ligands were obtained characterised on example crystalline dichloropalladium complex...
Abstract A wide range of commercially available aldehydes have been applied to Knoevenagel condensation reaction give E-alkenylphosphine oxides and vinylphosphine oxides. The readily phosphinoylacetic acids derived from P(O)–H compounds were used as the starting materials in reaction, providing a highly stereoselective efficient method for constructing α,β-unsaturated phosphine Moreover, this simple practical procedure provides an alternative more environmentally friendly synthesis strategy...
In this study, we explore the synthesis and solid-state characterization of four coumarin-3-carboxylic acid esters, each modified at C-3 position with different cycloalkyl groups: cyclohexyl, menthyl, iso-pulegyl. We conducted a detailed analysis these compounds utilizing variety techniques such as single-crystal X-ray diffraction, nuclear magnetic resonance (NMR), Fourier-transform infrared (FTIR) spectroscopy. Additionally, calculated dipole moments for molecules. Our findings include...
This paper presents the efficient reduction of phosphinoylacetic acid esters and 3-phosphorylated coumarin to their corresponding phosphino-boranes using BH₃-THF complexes. Optimized conditions for resulted in high yields phosphinoborates. The straightforwardness efficiency process were demonstrated diarylphosphinoylacetic ethyl esters, as well P-stereogenic L-menthyl where simultaneous strong P=O bond ester group was exclusively observed first time. study also highlighted significant...
Colorectal cancer (CRC) is a global problem. Oncology currently practices conventional methods of treating this carcinoma, including surgery, chemotherapy, and radiotherapy. Unfortunately, their efficacy low; hence, the exploration new therapies critical. Recently, many efforts have focused on developing safe effective anticancer compounds. Some them include cannabinoids. In present study, we obtained cannabinoids, such as cannabidiol (CBD), abnormal cannabigerol (abn-CBG), cannabichromene...
The series of C2-symmetric biaryl core-based non-racemic bisphosphines possessing substituents different electronic properties: both EDG and EWG were obtained in a short sequence good yielding transformations, started from commercial 1,3-dimethyl-2-nitrobenzene. Several approaches leading to the desirable ligands practically evaluated. Notably, synthesis entire could be performed with utilization single early-stage precursor DIDAB (6,6'-diiodo-2,2',4,4'-tetramethylbiphenyl-3,3'-diamine),...
Coumarins represent an important family of naturally occurring oxygen-containing heterocyclic compounds. With their biological activity, they are structural element many broadspectrum drugs, exhibiting anti-inflammatory [1], anticoagulant [2], antifungal [3], anticancer [4] or antiviral [5].