A5035509440- Dialysis and Renal Disease Management
- Muscle and Compartmental Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Electrolyte and hormonal disorders
- Advanced Fluorescence Microscopy Techniques
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Acute Kidney Injury Research
- Nutrition and Health in Aging
- Healthcare cost, quality, practices
- Bone fractures and treatments
- Abdominal Surgery and Complications
- Biotin and Related Studies
- Orthopedic Surgery and Rehabilitation
- Healthcare Systems and Public Health
- Myasthenia Gravis and Thymoma
- Microbial Natural Products and Biosynthesis
- Photoreceptor and optogenetics research
- bioluminescence and chemiluminescence research
- Heart Rate Variability and Autonomic Control
- Biochemical and Structural Characterization
- Cell Image Analysis Techniques
- Streptococcal Infections and Treatments
- Methemoglobinemia and Tumor Lysis Syndrome
- Neonatal and Maternal Infections
- Liver Disease and Transplantation
S. M. Kirov Military Medical Academy
2020-2025
Institute of Bioorganic Chemistry
2002-2004
Russian Academy of Sciences
2002
Institute of Immunological Engineering
1992-1993
Increasing number of studies’ results indicate that intestinal microbiota may be involved in the development and maintenance hypertensive phenotype patients with end-stage renal disease. Various metabolites bacteria are considered as potential modulators this association. Objective. To study relationship between levels uremic toxins microbial origin blood serum, well content short-chain fatty acids faeces 24-hour pressure profile indicators on long-term hemodialysis. Materials methods. Daily...
The yellow fluorescent protein (zFP538) from coral Zoanthus sp. belongs to a family of green (GFP). Absorption and emission spectra zFP538 show an intermediate bathochromic shift as compared with number recently cloned GFP-like red nonfluorescent chromoproteins the DsRed subfamily. Here we report that chromophore is very close, if not identical, in chemical structure DsRed. To gain insight into mechanism fluorescence chemistry, studied three chromophore-containing peptides isolated enzymatic...
The purple chromoprotein (asFP595) from Anemonia sulcata belongs to the family of green fluorescent protein (GFP). Absorption and emission spectra asFP595 are similar those a number recently cloned GFP-like red proteins DsRed subfamily. earlier proposed chromophore structure [Martynov, V. I.; et al. (2001) J. Biol. Chem. 276, 21012−21016] was postulated result an "alternative cyclization" giving rise pyrazine-type six-membered heterocycle. Here we report that is actually very close in...
Of all cases of acute kidney injury (AKI), 45-70% are associated with sepsis. Lethality in sepsis-associated AKI requiring renal replacement therapy (RRT) ranges from 40 to 50%, and combined other organ dysfunctions - 60-80%. In order improve the results treatment sepsis septic shock, various methods extracorporeal detoxification (ECD) have been developed. The effectiveness these is controversial. sepsis, RRT used not only replace impaired function kidneys, but also remove excess cytokines...
BACKGROUND . The lack of data on the epidemiology presarcopenia/sarcopenia leads to an underestimation role this condition in structure morbidity and mortality haemodialysis patients theRussian Federation. THE AIM : study epidemiological aspects presarcopenia /sarcopenia with chronic kidney disease stage 5d. PATIENTS AND METHODS This comprised 317 receiving programmed bicarbonate for 8.2 ± 5.1 years, among them 171 women 146 men, average age was 57.1 11.3 years. assessment presence...
<h3></h3> Септический шок является наиболее опасным проявлением сепсиса. В 55—73% случаев течение септического шока осложняется развитием острого повреждения почек, что ведет к увеличению показателя летальности до уровня, превышающего 60%. <h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Сопоставить детоксикационную эффективность применения различных современных методов эфферентной терапии при лечении пациентов с септическим шоком, осложненным острым повреждением путем изучения динамики уровня эндотоксина и...
ZAO ECOlab (Russia) developed Line Blot Syphilis, a new test system on the basis of linear immunoblotting method using Treponema рallidum recombinant antigens. The article assessed diagnostic value Syphilis in form confirmatory test. As part conducted study, demonstrated its absolute sensitivity and specificity to serum-positive (n = 237) serum-negative 114) samples, which presence or absence Т.pallidum antibodies was confirmed by two treponemal tests. result examining 14 samples attributed...
The objective was to evaluate the effect of renal replacement therapy on concentration tigecycline in blood treatment patients with sepsis and acute kidney injury. Materials methods . serum level analyzed three sepsis-associated injury against back -ground (RRT) hemodiafiltration mode. quantitative content determined by high-performance liquid chromatography. Results Significant variability levels revealed (AKI) under conditions use RRT. standard dosage regimens this situation may be...
Peritoneal dialysis is an effective method of renal replacement therapy. Currently, different opinions have been put forward as to which catheter implantation technique preferable for peritoneal dialysis. In this study, the application laparoscopic and improving effectiveness in patients with stage 5 chronic kidney disease substantiated. The study included 1,228 who received medical care by were observed 26 centers between 2000 2020. Group 1 open (n = 1105 people; 477 men [43%], 628 women...
Acute cerebrovascular accidents in patients with end-stage chronic kidney disease are an important but not well understood problem. The main difficulty is the lack of approved clinical guidelines and large multicenter studies that would allow determination a proven approach to therapy combination these diseases. This group rarely included trials has high risks complications. Up third strokes receiving hemodialysis develop hospital classified as intrahospital. Assessing associated performing...
The relevance. Meropenem is a broad-spectrum carbapenem antibiotic widely used to treat patients with sepsis / septic shock. Critically ill are usually supported one of the forms extracorporeal blood purification. However, data on effect various support techniques pharmacokinetics and pharmacodynamics meropenem insufficient or contradictory. Aim: To evaluate effectiveness dosage regimens in treatment during Materials methods. Plasma concentrations were monitored three critically Patients...
The objective: to study in vitro adsorption properties of various devices for selective lipopolysaccharide (LPS) adsorption. Subjects and Methods: Various methods closed circuit circulating bovine serum endotoxin solutions were used. was perfused using an LPS sorption device 240 min. Serum samples collected before the start perfusion, 30, 60, 120, 150, minutes after circulation. concentrations measured by turbidimetric method. One column polymyxin hemoperfusion three lipopolysaccharides...
Procedures using iodine-containing X-ray contrast agents pose a risk to kidney function, especially in patients with pre-existing renal dysfunction. Contrast-induced nephropathy is the third most common cause of acute injury, and high-risk groups incidence contrast-induced may approach 20-30 %. Therefore, assessing reducing remains very important issue. There no treatment for world, so main focus on its prevention. This methodological article describes detail definition, methodology risks...
The effectiveness of antibacterial therapy is a critical factor to improve treatment outcomes in sepsis patients. Impaired renal function and replacement lead significant change the pharmacokinetic parameters most intravenous drugs, which many cases accompanied by insufficient or excessive concentration blood results failure. article presents current views describes problems for during use extracorporeal detoxification methods. objective : analyze publications on detoxification. Results:...
Relevance. Discussion of the criteria for decision making “amputation vs. preservation”, when viability extremity is uncertain, has been continuing. The case description. lower a serviceman was injured by caterpillar tractor. severity damage determined following conditions: open segmental fracture femoral diaphysis, 5 cm traction-compression popliteal artery, acute thrombosis and tibial arteries, sciatic nerve damage, circular detachment thigh skin, hemorrhage, II degree shock, uncompensated...
The results of the determination levels apoptosis in vitro lymphocytes during procedures extracorporeal photochemotherapy (extracorporeal photopheresis) using flow cytometry are described. It was found that carrying out photopheresis does not have a significant effect on viability cells immediately after procedures. Thus, relative content living samples isolation mononuclear fraction peripheral blood did differ from both prepared for and this procedure. should be noted lead to rapid cell...
Anti‑NMDA encephalitis is a rare autoimmune disease of the central nervous system caused by synthesis autoantibodies to NR1/NR2 subunits NMDA receptor, characterized development acute mental, cognitive, motor, autonomic disorders, epileptic syndrome and hypoventilation.The article presents three‑year observation patient 34 years old with anti‑NMDA ncephalitis associated late‑ stage ovarian teratoma, accompanied an increase titer antibodies receptors in serum 1:640.Based on detailed analysis...