A5091584832- T-cell and B-cell Immunology
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Renal Diseases and Glomerulopathies
- Immunotherapy and Immune Responses
- Pharmaceutical Economics and Policy
- Angiogenesis and VEGF in Cancer
- Mycobacterium research and diagnosis
- Pleural and Pulmonary Diseases
- Immunodeficiency and Autoimmune Disorders
- RNA Interference and Gene Delivery
- Peripheral Artery Disease Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Kidney Disease and Diabetes
- Biosimilars and Bioanalytical Methods
- Peripheral Neuropathies and Disorders
- Ovarian cancer diagnosis and treatment
- Platelet Disorders and Treatments
- Multiple Myeloma Research and Treatments
- Renal cell carcinoma treatment
- Lipoproteins and Cardiovascular Health
- Biomedical Ethics and Regulation
- Immune Response and Inflammation
Peking University Shenzhen Hospital
2021-2025
Guangdong Medical College
2017-2021
University of Illinois Urbana-Champaign
2021
University of Illinois Chicago
2021
Illinois College
2021
Key Laboratory of Guangdong Province
2017
Identifying alpha-fetal protein (AFP)-negative focal hepatic lesions presents a significant challenge, particularly in China. We sought to develop an economically portable tool for the diagnosis of benign and malignant liver with AFP-negative status, explore its clinical diagnostic efficiency. A retrospective study was conducted at Peking University Shenzhen Hospital from January 2017 February 2023, including total 348 inpatients space-occupying lesions. The used training set 252 September...
Genetic and epigenetic mechanisms regulate antimicrobial immunity against Mycobacterium tuberculosis (Mtb) infection.The present study assessed circular RNA TRAPPC6B (circTRAPPC6B) for immune functions defined wherein circTRAPPC6B regulates Mtb growth, autophagy microRNA in macrophages.The infection of monocytes/macrophages resulted a significantly decreased level that inhibited intracellular growth macrophages. Conversely, expression enhanced or autophagy-associated protein LC3-II...
Little is known about how tuberculosis (TB) impairs dendritic cell (DC) function and anti-TB immune responses. We previously showed that the B T lymphocyte attenuator (BTLA), an inhibitory receptor, involved in TB pathogenesis. Here, we examined whether BTLA expression affects phenotypic functional aspects of DCs. Active patients exhibited higher myeloid cells (mDCs) plasmacytoid DCs (pDCs) subsets compared with healthy controls (HCs). was similarly high untreated TB, relapse,...
Abstract IL-35 is an anti-inflammatory cytokine and thought to be produced by regulatory T (Treg) cells. A previous study found that was upregulated in the serum of patients with active tuberculosis (ATB), IL-35-producing B cells infiltrated tuberculous granuloma ATB. Purified from such generated more after stimulation antigens Mycobacterium secreted IL-10. However, function underlying mechanisms TB progression have not been investigated. The present expression mRNA subsets Ebi3 p35 elevated...
Numerous studies have suggested that circular RNAs (circRNAs), a type of non‑coding RNA lacking 5'‑caps and 3'‑poly(A) tails, are involved in the biological processes various human diseases. However, little is known about their functions diagnostic value active pulmonary tuberculosis (APTB). The aim present study was to examine whether hsa_circ_0001380 able serve as biomarker for patients with APTB. expression level detected peripheral blood 32 APTB 31 healthy volunteers by reverse...
B cell activating factor (BAFF), a member of the tumor necrosis family, is key cytokine for survival, function that essential maturation and memory. The expression levels BAFF its potential contribution to remain elusive in patients with tuberculous pleural effusion (TPE). present study enrolled 40 healthy controls (HC) 45 TPE patients, investigated plasma effusion. Concomitantly, subsets including naïve (CD19+IgD+CD27‑), unswitched (CD19+IgD+CD27+), switched (CD19+IgD‑CD27+), total memory...
Background Data on the prevalence of monoclonal gammopathy undetermined significance (MGUS) in China are very limited. Our aim was to determine and clinical characteristics MGUS a large Chinese population.
Background: Genetic and epigenetic mechanisms appear to regulate antimicrobial immunity against Mycobacterium tuberculosis (Mtb) infection. Methods: We assessed circular RNA TRAPPC6B (circTRAPPC6B) for immune functions defined whereby circTRAPPC6B regulates Mtb growth, autophagy microRNA in macrophages. Findings: While infection of monocytes/macrophages resulted a significantly decreased level, inhibited intracellular growth Whereas, expression enhanced or autophagy-associated protein LC3-II...
Abstract Background: To make early prediction of immunoglobulin A nephropathy (IgAN) before renal biopsy, we developed and validated a new non-invasive nomogram for the IgAN in primary glomerulonephritis (GN) south China. Methods: total 431 patients were included this study additional 113 as independent test cohorts to validate our results. stepwise regression model was used features selection. Multivariate logistic analysis with 5-fold cross validation result Performance assessed respect...