A5058914149- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Cancer Genomics and Diagnostics
- Hematopoietic Stem Cell Transplantation
- Genomic variations and chromosomal abnormalities
- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Advanced biosensing and bioanalysis techniques
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- DNA and Nucleic Acid Chemistry
- Protein Degradation and Inhibitors
- Renal and related cancers
- Immune Cell Function and Interaction
- Hematological disorders and diagnostics
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Congenital Ear and Nasal Anomalies
- Chromosomal and Genetic Variations
City Of Hope National Medical Center
2013-2023
City of Hope
2012-2023
Murata (United States)
2020
University of Colorado Denver
1996
University of Denver
1987
Purpose Double-hit lymphomas (DHLs) and double-expressor (DELs) are subtypes of diffuse large B-cell lymphoma (DLBCL) associated with poor outcomes after standard chemoimmunotherapy. Data limited regarding patients relapsed or refractory (rel/ref) DEL DHL who undergo autologous stem-cell transplantation (ASCT). We retrospectively studied the prognostic impact status on ASCT in rel/ref DLBCL. Methods Patients chemotherapy-sensitive DLBCL underwent at two institutions whom archival tumor...
Sezary syndrome (SS) and tumor-stage mycosis fungoides (MF) are generally incurable with currently available treatments. We conducted a retrospective study to evaluate the outcome of allogeneic hematopoietic stem-cell transplantation (HSCT) in this patient population.From August 1996 through October 2002, eight patients advanced MF/SS underwent HSCT at our institution. All were heavily pretreated, having failed median number seven prior therapies (range, five 12). Clonal T-cell populations...
Immunophenotypic studies are essential to distinguish acute lymphoblastic leukemia (ALL) from minimally differentiated myeloid (AMLM0) and classify ALL into immunologic subtypes. Frequently, immunophenotyping identifies antigen expression in ALL, causing a potential diagnostic problem. To evaluate the immunophenotype of we studied 210 cases pediatric adult by flow cytometry compared results with French-American-British (FAB) Cooperative Group classification karyotypic findings....
Background Desmoplastic small round cell tumor (DSRCT) is a rare malignant that generally manifests as abdominal paraserosal masses and affects mainly male adolescents young adults. When presenting within visceral organs, the diagnosis of DSRCT poses significant difficulties. Methodology Four primary renal in children diagnosed during 3-year period are basis this report. The medical records pathologic material were reviewed, including immunohistochemical, ultrastructural,...
Abstract Purpose: We performed detailed genomic analysis on 87 cases of de novo diffuse large B-cell lymphoma germinal center type (GCB DLBCL) to identify characteristics that are associated with survival in those treated R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). Experimental Design: The were extensively characterized by combining the results IHC, cell-of-origin gene expression profiling (GEP; NanoString), double-hit GEP (DLBCL90), FISH cytogenetic for...
The tumor microenvironment (TME) is important in the pathogenesis and prognosis of lymphoma. Previous studies have demonstrated that features diffuse large B-cell lymphoma (DLBCL) TME can be associated with prognosis, but questions remain about mechanisms underlying these features, interplay between cells local TME. Therefore, we performed multispectral immunofluorescence (mIF) using two 6-color panels to interrogate cellular proportions T-cell subsets, macrophages, natural killer 57 cases...
Therapy-related myelodysplastic syndrome is a long-term complication of cancer treatment in patients receiving cytotoxic therapy, characterized by high-risk genetics and poor outcomes. Allogeneic hematopoietic cell transplantation the only potential cure for this disease, but prognostic impact pre-transplant clinical features has not yet been fully characterized. We report here genetic characteristics outcomes relatively large cohort with therapy-related (n=67) who underwent allogeneic...
Double-hit lymphomas (DHLs) and double-expressor (DELs) are associated with resistance to frontline salvage immunochemotherapy, as well autologous stem cell transplantation (SCT). We hypothesized that allogeneic SCT (alloSCT) could overcome the chemoresistance DEL/DHL. retrospectively studied impact of DEL/DHL status in a multicenter cohort patients who underwent alloSCT for relapsed/refractory (rel/ref) aggressive B non-Hodgkin lymphoma (B-NHL). Seventy-eight transplanted at 3 centers whom...
Multicolor spectral karyotyping allows simultaneous visualization of all human chromosomes and screening for chromosomal rearrangements without a priori knowledge any abnormalities involved. Based on this potentially increased sensitivity, we investigated, in preliminary manner, whether could detect cytogenetic aberrations karyotypically normal leukemia. The test population was comprised 28 cryopreserved, cytogenetically acute myeloid leukemia (AML) samples from patients registered to...
Acute lymphoblastic leukemia (ALL) of B-cell lineage may be classified using the French-American-British (FAB) classification as LI, L2, or L3 type. LI and L2 ALLs characteristically express terminal deoxynucleotidyl transferase (TdT) are surface immunoglobulin (sIg)-negative. In contrast, ALL is typically TdT-negative sIg-positive. However, in a few large studies children with ALL, sIg expression has been reported less than 2% L1 neoplasms. these sIg-positive cases, IgM usually detected, Ig...
We report feasibility and response results of a phase II study investigating prolonged weekly bortezomib dexamethasone followed by thalidomide as maintenance therapy after single autologous stem cell transplantation (ASCT) in patients with multiple myeloma. Within 4 to 8 weeks ASCT, received for six cycles, more cycles. Thalidomide alone was continued until disease progression. Forty-five underwent ASCT. Forty started therapy; these, 36 four 32 completed cycles bortezomib. Of these 40...
Elevated cyclin D1 (CCND1) expression levels in mantle cell lymphoma (MCL) are associated with aggressive clinical manifestations related to chemoresistance, but little is known about how this important proto-oncogene contributes the resistance of MCL. Here, we showed that RNA interference-mediated depletion CCND1 increased caspase-3 activities and induced apoptosis human MCL lines UPN-1 JEKO-1. In vitro xenotransplant studies revealed toxic effect cells was likely due increase histone H2AX...
Cyclophosphamide (Cy)/etoposide combined with fractionated total body irradiation (FTBI) or i.v. busulfan (Bu) has been the main conditioning regimens for allogeneic hematopoietic cell transplantation (alloHCT) young patients acute myelogenous leukemia (AML) eligible a myeloablative (MAC) regimen. Recent data suggested that Bu could be preferred regimen in myeloid malignancies. However, Bu-based are associated higher rates of sinusoidal obstruction syndrome. Here we report long-term survival...
Summary We analysed the long‐term outcomes of 60 multiple myeloma patients who underwent reduced intensity allogeneic stem cell transplantation between A ugust 2000 and M arch 2008. Regimens included fludarabine melphalan conditioning (flu‐mel regimen) for haematopoietic transplant ( HCT ) or a planned tandem regimen consisting high‐dose autograft followed by low‐dose total body irradiation (auto‐allo regimen). Donors human‐leucocyte‐antigen‐matched siblings n = 55) matched unrelated donors...
Abstract Acute myeloid leukemia (AML) occurring concurrently with or after untreated chronic lymphocytic (CLL) is rare. We report a case of 59‐year‐old man who was evaluated for anemia, thrombocytopenia, and leukocytosis circulating blasts. On the basis morphology immunophenotyping results, preliminary diagnosis myelomonocytic concurrent CLL considered. Subsequently, cytogenetic analysis leukemic blood specimen revealed inv(16)(p13.1q22) secondary trisomy 22 in sideline clone. Fluorescence...
Burkitt lymphoma patients with bulky disease often have bone marrow involvement. However, leukemic presentation of in the absence a mass (pure leukemia; PBL) is uncommon. Both PBL and lymphoma/leukemia, presenting tumor involvement (BLL), are considered stage IV disease, which associated poor prognosis. there limited information on prognosis adults because they typically been included cohorts BLL. This study identified 23 patients, 10 13 BLL cases. Complex karyotypes (100%) were seen all...