A5001438849- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Cancer Risks and Factors
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Biochemical Acid Research Studies
- T-cell and Retrovirus Studies
- Monoclonal and Polyclonal Antibodies Research
- Acute Lymphoblastic Leukemia research
- CNS Lymphoma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Liver Disease Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Diet, Metabolism, and Disease
- Lipid metabolism and biosynthesis
- Biosimilars and Bioanalytical Methods
- Biochemical and Molecular Research
- Sepsis Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
City Of Hope National Medical Center
2017-2024
City of Hope
2016-2024
UCLA Medical Center
2013-2017
University of California, Los Angeles
2011-2017
The Lundquist Institute
2011-2017
Cancer Research Center
2014
Harbor–UCLA Medical Center
2013
Nonalcoholic fatty liver disease is common in developed countries and associated with obesity, metabolic syndrome, type 2 diabetes. T deficiency a risk factor for developing these deficiencies, but its role hepatic steatosis has not been well studied. We investigated the effects of on pathogenesis rats fed high-fat diet (HFD). Adult male were randomly placed into four groups treated 15 weeks: intact regular chow (RCD), liquid HFD (I+HFD), castrated (C+HFD), replacement (C+HFD+T). Fat...
Fludarabine/cyclophosphamide (Flu/Cy) is established for lymphodepletion (LD) prior to standard-of-care CAR T-cell therapy lymphoma. There ongoing need test alternative LD regimens preserve efficacy, improve safety, and address challenges including the recent national fludarabine shortage. We retrospectively evaluated outcomes among patients with relapsed/refractory aggressive B-cell lymphoma who received bendamustine (n = 27) or Flu/Cy 42) before axicabtagene ciloleucel (axi-cel) at our...
Bridging therapy (BT) with systemic (ST), radiation (RT), or combined-modality (CMT) is increasingly being utilized prior to chimeric antigen receptor (CAR) T-cell for large B-cell lymphoma (LBCL). We report the long-term outcomes of patients who received commercial CAR without BT.
Double-hit lymphomas (DHLs) and double-expressor (DELs) are associated with resistance to frontline salvage immunochemotherapy, as well autologous stem cell transplantation (SCT). We hypothesized that allogeneic SCT (alloSCT) could overcome the chemoresistance DEL/DHL. retrospectively studied impact of DEL/DHL status in a multicenter cohort patients who underwent alloSCT for relapsed/refractory (rel/ref) aggressive B non-Hodgkin lymphoma (B-NHL). Seventy-eight transplanted at 3 centers whom...
We previously showed that testosterone (T) deficiency enhanced high-fat/low-carbohydrate diet (HFD)-induced hepatic steatosis in rats independent of insulin resistance and T replacement reduced macrovesicular fat accumulation inflammation. The present report explores the mechanism Tʼs protective effects on HFD-induced steatohepatitis. Adult male were randomized into four treatment groups for 15 wk: intact regular chow or HFD, castrated HFD with without replacement. Fatty acid β-oxidation de...
On 1 April 2016, the Food and Drug Administration approved Defitelio, known for many years as Defibrotide (DF), marketing in United States. The indication is severe hepatic veno-occlusive disease (sVOD) following high-dose chemotherapy autologous bone marrow transplantation, a toxicity of therapy with high mortality. not kind oligonucleotide drug beloved by molecular biologists proponents personalized medicine. Its very complicated mechanism action, which still elusive, without question...
Outcomes after programmed death-1 (PD-1) blockade in B-cell lymphomas are disappointing with few durable responses. Histone deacetylase inhibitors exhibit favorable immunomodulatory effects and demonstrate synergistic anti-tumor immune responses anti-PD-1 therapy preclinical models. We, therefore, developed a phase I study to evaluate the safety preliminary efficacy of pembrolizumab vorinostat relapsed/refractory lymphomas. Patients were treated dose-escalation cohort using Rolling 6 design...
To enhance protective cytomegalovirus (CMV)-specific T cells in immunosuppressed recipients of an allogeneic hematopoietic cell transplant (HCT), we evaluated post-HCT impact vaccinating healthy HCT donors with Triplex. Triplex is a viral vectored recombinant vaccine expressing three immunodominant CMV antigens. The vector modified vaccinia Ankara (MVA), attenuated, non-replicating poxvirus derived from the virus strain Ankara. It demonstrated tolerability and immunogenicity adults...
Background: The purpose of this study was to examine the association between baseline skeletal muscle measurements, acute toxicity (immune effector cell–associated neurotoxicity syndrome [ICANS], cytokine release syndrome), and treatment efficacy in patients undergoing CAR T-cell therapy for B-lineage lymphoma. Patients Methods: Skeletal measurements were obtained from automated CT 226 consecutive who received 2015 2021. Kaplan-Meier method used progression-free survival (PFS) overall (OS)...
Abstract Introduction In November 2020, the FDA issued an emergency use authorization (EUA) for monoclonal antibody (mAb) therapy in patients with mild‐to‐moderate COVID‐19 at high risk disease progression. Methods We retrospectively reviewed 38 adult hematology who received mAbs from 11/2020 to 2/2021. Results Thirty (79%) bamlanivimab and 8 (21%) casirivimab‐imdevimab. Four (11%) were hospitalized due COVID‐19, two (5%) progressed severe one patient (3%) died within 30 days disease. Most (...
Purpose/objective(s) Bridging radiation therapy (bRT) is increasingly being utilized prior to chimeric antigen receptor (CAR) T-cell for large B-cell lymphoma (LBCL). It unknown how the extent of cytoreduction during bRT impacts outcomes. Materials/methods We retrospectively reviewed patients with LBCL treated followed by CAR therapy. Metabolic tumor volume (MTV), maximum standardized uptake value (SUV max ), SUV mean , and total lesion glycolysis (TLG) were extracted from...