A5026544086- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Renal cell carcinoma treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Immune cells in cancer
- Infectious Aortic and Vascular Conditions
- Immune Cell Function and Interaction
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Biliary and Gastrointestinal Fistulas
- Monoclonal and Polyclonal Antibodies Research
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Orthopedic Infections and Treatments
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- Aortic aneurysm repair treatments
- Vascular Procedures and Complications
- Multiple Myeloma Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
University of Leeds
2013-2024
St James's University Hospital
2015-2024
Leeds Teaching Hospitals NHS Trust
2018
University of Manchester
2012-2017
North Manchester General Hospital
2011-2017
Cancer Research UK Manchester Institute
2013-2016
Leeds General Infirmary
2013-2015
University of Salford
2012-2014
Salford Royal NHS Foundation Trust
2012-2014
Royal Blackburn Teaching Hospital
2011
Pancreatic cancer (PC) often presents late with poor survival. While role of immunosuppressive cells in preclinical studies provided help to develop immunotherapeutic agents, these remain under investigation PC. The aim this study was characterise the different subsets myeloid-derived suppressor (MDSCs) and evaluate their level function circulation tissue PC patients. Significant increases circulating tumour-infiltrating granulocytic (Lin-HLA-DR-CD33+CD11b+CD15+), but not monocytic...
Nanomedicines, while having been approved for cancer therapy, present many challenges such as low stability, rapid clearance, and nonspecificity leading to off-target toxicity. Cubosomes are porous lyotropic liquid crystalline nanoparticles that have shown great premise drug delivery vehicles; however, their behavior in vivo is largely underexplored, hindering clinical translation. Here, we engineered cubosomes based on the space group Im3m loaded with copper acetylacetonate a model drug,...
Abstract Background Laparoscopic distal pancreatectomy (LDP) is increasingly being performed as an alternative to open surgery. Whether the implementation and corresponding learning curve of LDP have impact on patient outcome unknown. The aim was investigate temporal trends in practice across UK centres. Methods This a retrospective multicentre observational cohort study 11 tertiary referral centres between 2006 2016. analysed by pooling data for first 15 consecutive patients who had...
Abstract Background Cystgastrostomy is the commonest method of internal drainage pancreatic pseudocysts ( PPs ). While large and persistent retrogastric are amenable to laparoscopic cystgastrostomy, potential benefits this minimally invasive approach over open surgery remain be demonstrated. The aim study was compare outcomes approaches for cystgastrostomy. Methods Patients who underwent cystgastrostomy LCG ) were matched on a 3:1 basis those OCG according age, sex distribution, size...
// May Abd Al Samid 1, 2, * , Belal Chaudhary Yazan S. Khaled 3 Basil J. Ammori Eyad Elkord 1 Biomedical Research Centre, School of Environment and Life Sciences, University Salford, Manchester, United Kingdom 2 College Medicine Health Arab Emirates University, Ain, Institute Cancer These authors contributed equally to this work Correspondence to: Elkord, e-mail: eelkord@uaeu.ac.ae e.elkord@salford.ac.uk eyad.elkord@manchester.ac.uk Keywords: regulatory T cells, markers, GARP/LAP, FoxP3,...
Advances in surgical technologies allowed safe laparoscopic pancreaticoduodenectomy (LPD). The aim of this study is to compare the oncologic outcomes LPD open (OPD) terms safety and recurrence rate.A cohort 30 patients were matched for age, sex, American Society Anaesthesiologists, tumor size, pancreatic duct diameter, histopathologic diagnosis on a 1:1 basis (15 LPD, 15 OPD). Comparison between groups was performed intention-to-treat basis. Survival following resection compared using...
Introduction: Although the laparoscopic approach to distal pancreatectomy for benign and malignant diseases is largely replacing open surgery in some centers, well-designed studies comparing these approaches are limited. We present a case-matched study that compares outcomes of (LDP) (ODP). Methods: Of 112 patients (51 female) who underwent between January 2002 December 2011, 44 were matched on 1:1 basis (22 LDP, 22 ODP) according age, sex, tumor size. Outcomes compared an intention-to-treat...
Pancreatic resection and/or ductal drainage are common surgical options in the management of unremitting abdominal pain chronic pancreatitis (CP). We describe results largest UK series laparoscopic approach to pancreatic duct and head for CP.Patients with CP intractable requiring duodenum-preserving (Berne modification Beger procedure) or Puestow procedure were offered surgery by a single surgeon. The shown represent median (range).Six patients (3 males) (alcohol induced, n=4; idiopathic,...
Iliac artery-enteric fistula is a rare cause of lower GI bleeding and can life-threatening consequences. A high degree clinical suspicion needed in patients with previous aortic surgery to allow early multidisciplinary intervention.This case study discusses the staged management 78-year-old patient presenting gastrointestinal (GI) secondary an aortoiliac graft-enteric (GEF) into sigmoid colon on background adenocarcinoma diverticular disease. The had aorto bi-iliac synthetic dacron graft...
Theranostic nanoparticles hold promise for simultaneous imaging and therapy in colorectal cancer.
Congenital insensitivity to pain is a rare condition that often undiagnosed until patients present with variety of musculoskeletal problems. A major sequel these orthopaedic manifestations the development heterotopic ossification and callus formation following fractures, eventually leading Charcot's joint. This case reports on 7-year-old child who was diagnosed congenital type V, after he presented in our clinic fractures metatarsals his left foot while continuing weight bear, without any...
Side branch IPMN (SB-IPMN) of the pancreas has a malignancy rate between 10 and 20%. We hypothesized that surveillance at longer intervals on selected patients with SB-IPMN might be indicated.This is retrospective study prospectively collected data 276 presenting from 2000 to 2010. After 2007, we opted screen our intervals, initially 12 months then 24 using MR if no "worrisome features" were present.Complete sets for 261 analysed aged 78 (40-91) years. 232 had sole while 92% incidental (n =...
Background: Laparoscopic surgery has extended its applications to resection of malignancies with favorable results. We report the first successful simultaneous laparoscopic subtotal colectomy and pancreaticoduodenectomy (PD) in a patient familial adenomatous polyposis (FAP). Case Report: A 37-year-old man presented obstructive jaundice. Gastroscopy biopsies revealed large ampullary tubulovillous adenoma mild dysplasia (Spigelman stage III). colonoscopy for suspicion FAP numerous right-sided...
Salmonella osteomyelitis occurs infrequently in healthy children and can manifest the subacute form. This condition has only been reported few cases previously. We report first case of primary haematogenous calcaneum a 12-year-old child. The patient made uneventful recovery following surgical drainage antibiotic therapy. Histology tissue biopsy confirmed diagnosis livingstone infection. Although be difficult to establish, it should considered as an aetiological factor even children.
Anal gland carcinoma (AGC) is rare, and its innocuous presentation developing immunohistochemical profile make the diagnosis of it challenging. Predominant presenting symptoms include anal pain, rectal bleeding presence a perianal mass in advanced stages disease. Histological commonly reveals an intramural adenocarcinoma with normal unaffected overlying anorectal mucosa. Immunohistochemical analysis shows positive staining for cytokeratin (CK) 7 negative CK20. MUC5AC expression CK5/6 p53...