A5023335764- Neural dynamics and brain function
- Neuroscience and Music Perception
- Multisensory perception and integration
- Neurological disorders and treatments
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Neural Networks and Applications
- Genetic Neurodegenerative Diseases
- Diverse Music Education Insights
- Autism Spectrum Disorder Research
- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Transcranial Magnetic Stimulation Studies
- Neurotransmitter Receptor Influence on Behavior
Institut de Neurosciences de la Timone
2017-2025
Aix-Marseille Université
2020-2025
Emory University
2022-2024
Centre National de la Recherche Scientifique
2020-2024
Aligning Science Across Parkinson's
2024
Research Network (United States)
2024
Within the striatum, cholinergic interneurons, electrophysiologically identified as tonically active neurons (TANs), represent a relatively homogeneous group in terms of their functional properties. They display typical pause tonic firing response to rewarding events which are crucial importance for reinforcement learning. These responses uniformly distributed throughout dorsal striatum (i.e., motor and associative striatum), but it is unknown, at least monkeys, whether differences...
Abstract Prior studies have documented the role of striatum and its dopaminergic input in time processing, but contribution local striatal cholinergic innervation has not been specifically investigated. To address this issue, we recorded activity tonically active neurons (TANs), thought to be interneurons striatum, two male macaques performing self‐initiated movements after specified intervals seconds range elapsed. The behavioral data showed that movement timing was adjusted according...
Abstract There has been considerable progress in recent years toward understanding the neuronal mechanisms mediating time perception. Notably, striatum and its dopamine (DA) input from ventral midbrain are considered to be central for timing on scale of hundreds milliseconds seconds. The cholinergic interneurons (ChIs) provide an extensive local innervation, which closely interacts with striatal DA afferents. Both systems have shown influence synaptic plasticity shape transfer information...
The striatum, the main input structure of basal ganglia, is critical for action selection and adaptive motor control. To understand neuronal mechanisms underlying these functions, an analysis microcircuits that compose striatum necessary. Among these, cholinergic interneurons (ChIs) provide intrinsic striatal innervation whose dysfunction implicated in neuropsychiatric diseases, such as Parkinson's disease Tourette syndrome. ability to experimentally manipulate activity ChIs gain insights...
SUMMARY The study of motor cortices in non-human primates is relevant to our understanding human control, both healthy conditions and movement disorders. Calcium imaging miniature microscopes allow the multiple genetically identified neurons with excellent spatial resolution. We used this method examine activity patterns projection deep layers supplementary (SMA) primary areas (M1) four rhesus macaques. implanted gradient index lenses expressed GCaMP6f image calcium transients while animals...
Abstract The striatum and its dopaminergic input participate in temporal processing numerous studies provide evidence that interactions between dopamine acetylcholine are critical for striatal functioning. However, the role of local cholinergic innervation behaviors requiring precise timing has not been specifically investigated. Here, we recorded from presumed interneurons, identified as tonically active neurons (TANs), two male rhesus monkeys performing self-initiated movements after...