A5036041683- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Proteoglycans and glycosaminoglycans research
Cardiff University
2019-2023
Chondroitin sulfate (CS) is an important component of the extracellular matrix in multiple biological tissues. In cornea, CS glycosaminoglycan (GAG) exists hybrid form, whereby some repeating disaccharides are dermatan (DS). These CS/DS GAGs through their presence on proteoglycans, decorin and biglycan, help control collagen fibrillogenesis organization. also acts as a regulatory ligand for spectrum signaling molecules, including morphogens, cytokines, chemokines, enzymes during corneal...
(1) Background: Owing to its ready availability and ease of acquisition, developing chick corneal tissue has long been used for research purposes. Here, we seek ascertain the three-dimensional microanatomy spatiotemporal interrelationships cells (epithelial stromal), extracellular matrix, vasculature at corneo-scleral limbus as site stem cell niche chicken eye. (2) Methods: The (i.e., embryonic days (E) 16 18, just prior hatch) mature eyes was imaged using scanning electron microscopy (SEM),...
Chondroitin sulphate (CS) proteoglycans with variable sulphation-motifs along their glycosaminoglycan (GAG) chains are closely associated the stem cell niche of articular cartilage, where they believed to influence characteristics resident cells. Here, we investigated immunohistochemical distribution hybrid CS/dermatan (DS) GAGs in periphery adult chicken cornea, which is location cornea's a number species, using monoclonal antibody, 6C3, that recognises sulphation motif-specific CS/DS GAG...