A5066381055- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Muscle activation and electromyography studies
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Neuroscience and Neural Engineering
- Bone health and osteoporosis research
- Prosthetics and Rehabilitation Robotics
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Bone fractures and treatments
- Motor Control and Adaptation
- Pelvic and Acetabular Injuries
- Lower Extremity Biomechanics and Pathologies
- Sports injuries and prevention
- Elasticity and Material Modeling
- Astronomy and Astrophysical Research
- Balance, Gait, and Falls Prevention
- Galaxies: Formation, Evolution, Phenomena
- Medical Imaging and Analysis
- Sports Performance and Training
- Orthopedic Surgery and Rehabilitation
- Advanced Materials and Mechanics
- Dental Implant Techniques and Outcomes
- Stellar, planetary, and galactic studies
Imperial College London
2014-2024
Royal British Legion
2014-2024
SUNY Upstate Medical University
2020-2022
AstraZeneca (United Kingdom)
2017-2022
The Ohio State University
2020
Charing Cross Hospital
2018
University of California, Santa Cruz
2002-2014
Australian National University
2010
University of Edinburgh
2003-2006
University of Bath
2006
The Automated Planet Finder (APF) is a facility purpose-built for the discovery and characterization of extrasolar planets through high-cadence Doppler velocimetry reflex barycentric accelerations their host stars. Located atop Mount Hamilton, APF consists 2.4 m telescope its Levy spectrometer, an optical echelle spectrometer optimized precision velocimetry. features fixed-format spectral range from 374–970 nm, delivers "throughput" (resolution × slit width product) 114,000'', with...
The spinal motor neurons are the only neural cells whose individual activity can be noninvasively identified. This is usually done using grids of surface electromyographic (EMG) electrodes and source separation algorithms; an approach called EMG decomposition. In this study, we combined computational experimental analyses to assess how design parameters influence number properties identified units. We first computed percentage units that could theoretically discriminated within a pool 200...
We present the luminosity function and color-redshift relation of a magnitude-limited sample 145 mostly red field E/S0 galaxies at z < 1 from DEEP Groth Strip Survey (GSS). Most E/S0s (86%) form envelope in redshift-color diagram, consistent with predictions spectral synthesis models which dominant stellar population is formed redshifts > 1.5. Constructing full E/S0s, we find that there about 1.1--1.9 magnitude brightening rest-frame B band back to = 0.8 z=0, other studies. Together colors,...
Edge loading causes clinical problems for hard-on-hard hip replacements, and edge wear scars are present on the majority of retrieved components. We asked question: lines action joint muscles such that can occur in a well-designed, well-positioned acetabular cup? A musculoskeletal model, based cadaveric lower limb geometry, was used to calculate each muscle, every position within complete range motion, whether its contraction would safely pull femoral head into cup or contribute loading. The...
Fetal movements in the uterus are a natural part of development and known to play an important role normal musculoskeletal development. However, very little is about biomechanical stimuli that arise during utero, despite these being crucial bone joint formation. Therefore, objective this study was create series computational steps by which forces generated kick utero could be predicted from clinically observed fetal using novel cine-MRI data three fetuses, aged 20–22 weeks. A custom tracking...
Through much of the anatomical and clinical literature bone is studied with a focus on its structural architecture, while it rare for to be modelled using mechanics as opposed continuum approach in engineering literature. A novel mesoscale model femur presented which truss shell elements are used represent trabecular cortical bone, respectively. Structural optimisation strain-based adaptation algorithm incorporated within musculoskeletal finite element modelling framework predict structure...
Mechanical forces generated by fetal kicks and movements result in stimulation of the skeleton form stress strain. This is known to be critical for prenatal musculoskeletal development; indeed, abnormal or absent have been implicated multiple congenital disorders. However, mechanical strain experienced developing human utero never before characterized. Here, we quantify biomechanics during second half gestation modelling captured using novel cine-magnetic resonance imaging technology. By...
Deep learning biomechanical models perform optimally when trained with large datasets, however these can be challenging to collect in gait labs, while limited augmentation techniques are available. This study presents a data approach based on generative adversarial networks which generate synthetic motion capture (mocap) datasets of marker trajectories and ground reaction forces (GRFs). The proposed architecture, called autoencoder, consists an encoder compressing mocap latent vector,...
A mosaic of two 2k x 4k fully depleted, high resistivity CCD detectors was installed in the red channel Low Resolution Imaging Spectrograph for Keck-I Telescope June, 2009 replacing a monolithic Tektronix/SITe CCD. These CCDs were fabricated at Lawrence Berkeley National Laboratory (LBNL) and packaged characterized by UCO/Lick Observatory. Major goals detector upgrade increased throughput reduced interference fringing wavelengths beyond 800 nm, as well improvements maintainability...
We present Spitzer 16 μm imaging of the Great Observatories Origins Deep Survey (GOODS) fields. survey 150 arcmin2 in each two GOODS fields (North and South), to an average 3σ depth 40 65 μJy, respectively. detect ∼1300 sources both combined. validate photometry using 3–24 spectral energy distribution stars compared spectroscopic templates. Comparison with ISOCAM AKARI observations same shows reasonable agreement, though uncertainties are large. provide a catalog photometry, cross-correlated...
SUMMARY Functional adaptation of the femur has been studied extensively by embedding remodelling algorithms in finite element models, with bone commonly assumed to have isotropic material properties for computational efficiency. However, isotropy is insufficient predicting directionality bone's observed microstructure. A novel iterative orthotropic 3D algorithm proposed and applied a model whole femur. Bone was modelled as an optimised strain‐driven adaptive continuum local symmetry. Each...
The fetal membrane surrounds the fetus during pregnancy and is a thin tissue composed of two layers, chorion amnion. While rupture this normally occurs at term, preterm can result in increased risk mortality morbidity, as well danger infection mother. Although structural changes have been observed such cases, mechanical behaviour human vivo remains poorly understood challenging to investigate experimentally. Therefore, objective study was develop simplified finite element models membrane,...
Our understanding of the behaviour spinal alpha-motoneurons (MNs) in mammals partly relies on our knowledge relationships between MN membrane properties, such as size, resistance, rheobase, capacitance, time constant, axonal conduction velocity, and afterhyperpolarization duration. We reprocessed data from 40 experimental studies adult cat, rat, mouse preparations to empirically derive a set quantitative mathematical these electrophysiological anatomical properties. This validated framework,...
Our understanding of the firing behaviour motoneuron (MN) pools during human voluntary muscle contractions is currently limited to electrophysiological findings from animal experiments extrapolated humans, mathematical models MN not validated for data, and experimental results obtained decomposition electromyographical (EMG) signals. These approaches are in accuracy or provide information on only small partitions population. Here, we propose a method based combination high-density EMG...
Abstract The spinal motor neurons are the only neural cells whose individual activity can be non-invasively identified. This is usually done using grids of surface electromyographic (EMG) electrodes and source separation algorithms; an approach called EMG decomposition. In this study, we combined computational experimental analyses to assess how design parameters influence number properties identified units. We first computed percentage units that could theoretically discriminated within a...
The computational simulation of human voluntary muscle contraction is possible with EMG-driven Hill-type models whole muscles. Despite impactful applications in numerous fields, the neuromechanical information and physiological accuracy such provide remain limited because multiscale simplifications that limit comprehensive description internal dynamics during contraction. We addressed this limitation by developing a novel motoneuron-driven neuromuscular model, describes force-generating...
Functional adaptation of the femur has been investigated in several studies by embedding bone remodelling algorithms finite element (FE) models, with simplifications often made to representation bone's material symmetry and mechanical environment. An orthotropic strain-driven algorithm is proposed order predict femur's volumetric property distribution directionality its internal structures within a continuum. The was applied FE model femur, muscles, ligaments joints included explicitly....
Structural components designed to absorb energy and shield a more valuable structure ideally require mechanical properties that combine relatively high load-carrying capacity followed by practically zero stiffness. This ensures specified quantity may be absorbed within limited displacement any stress transfer the is minimized. Material damage has been historically mobilized provide such properties, but this obviously renders single-use. By contrast, mobilization of elastic instability can...