A5065178554- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Vitamin D Research Studies
- Adrenal Hormones and Disorders
- Psoriasis: Treatment and Pathogenesis
- IL-33, ST2, and ILC Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- T-cell and B-cell Immunology
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Gut microbiota and health
- Inflammasome and immune disorders
- Food composition and properties
- Urticaria and Related Conditions
- Neuropeptides and Animal Physiology
- Advancements in Transdermal Drug Delivery
- Microbial Metabolites in Food Biotechnology
- Protein Kinase Regulation and GTPase Signaling
- Fungal and yeast genetics research
- Exercise and Physiological Responses
- Food Allergy and Anaphylaxis Research
- Bacterial Genetics and Biotechnology
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
Leo Pharma (Denmark)
2016-2022
Technical University of Denmark
2015-2018
Rockefeller University
2015-2016
University of Copenhagen
2015
The University of Texas Southwestern Medical Center
1990
University of Chicago
1988
Neuropeptide Y (NPY) inhibited the Ca2+ current (ICa) in rat dorsal root ganglion neurons vitro. NPY sustained ICa evoked by steps to 0 mV from a holding potential of -40 and inactivating ICa, which was additionally more negative -80 mV. The effects on both phases were abolished if cells first treated with pertussis toxin (PTX). When combination GTP purified alpha-subunit guanine nucleotide-binding protein Go perfused into PTX-treated cells, inhibitory reappeared time-dependent fashion. or...
Complementary DNAs for the G protein alpha subunits Gi 1, 2, 3, and Go were expressed in Escherichia coli, four proteins purified to homogeneity. The recombinant exchange hydrolyze guanine nucleotide, are ADP-ribosylated by pertussis toxin, interact with beta gamma subunits. rates of dissociation GDP from 1 3 (0.03 min-1) an order magnitude slower than that rGo alpha; release 2 is also relatively slow (0.07 min-1). However, values kcat hydrolysis GTP three rGi approximately same, about min-1...
The interleukin (IL)-23/IL-17 immune axis is of central importance in psoriasis. However, the impact IL-17 family cytokines other than IL-17A psoriasis has not been fully established.To elucidate contribution psoriasis.To address expression and localization cytokines, lesional nonlesional skin samples from patients with were analysed by several complementary methods, including quantitative polymerase chain reaction, immunoassays, situ hybridization immunohistochemistry. Mechanistic studies...
Atopic dermatitis (AD) is a common inflammatory skin disorder characterized by heterogeneous and fluctuating disease course. To obtain detailed molecular understanding of both the temporal spatial variation in AD, we conducted longitudinal case-control study, which followed population, GENAD (Gentofte AD) cohort, mild-to-moderate patients with AD matched healthy controls for more than year. By use 1.5 mm minipunch biopsies, obtained 393 samples from lesional, nonlesional, multiple anatomical...
Glucocorticoids (GCs) are commonly used topical treatments for skin diseases but associated with both local and systemic side effects. In this study, we describe a selective non-steroidal glucocorticoid receptor (GR) agonist use, LEO 134310, which is rapidly deactivated in the blood resulting low exposure higher therapeutic index TPA-induced inflammation mouse model compared betamethasone valerate (BMV) clobetasol propionate (CP). Selectivity of 134310 GR was confirmed within panel nuclear...
The protein called p97 in mammals and Cdc48 budding fission yeast is a homo-hexameric, ring-shaped, ubiquitin-dependent ATPase complex involved range of cellular functions, including degradation, vesicle fusion, DNA repair, cell division. cdc48+ gene essential for viability yeast, point mutations the human orthologue have been linked to disease. To analyze function p97/Cdc48 further, we performed screen cold-sensitive suppressors temperature-sensitive cdc48-353 strain. In total, 29...
Introduction T-helper 17 (Th17) cytokines play a key role in the pathophysiology of psoriasis by driving inflammatory responses that lead to epidermal alterations. Markers differentiation, including proteins loricrin (LOR), filaggrin (FLG) and involucrin (IVL), are dysregulated psoriatic skin. The fixed-dose combination calcipotriol/betamethasone dipropionate (Cal/BD) foam clobetasol propionate (CP) widely used, effective topical treatments for psoriasis. In this study, we investigated...
Tape stripping is a non-invasive skin sampling technique, which has recently gained use for the study of transcriptome atopic dermatitis (AD), common inflammatory disorder characterized by defective epidermal barrier and perturbated immune response. Here, we performed BRB-seq-a low cost, multiplex-based, transcriptomic profiling technique-on tape-stripped from 30 AD patients healthy controls to evaluate methods' ability assess transcriptome. An signature consisting 91 differentially...