Abstract Purpose: To characterize the role of B cells on human papilloma virus (HPV)-associated cancer patient outcomes and determine effects radiation PD-1 blockade B-cell populations. Experimental Design: Tumor RNA-sequencing data from over 800 patients with head neck squamous cell carcinoma (HNSCC) cervical cancer, including a prospective validation cohort, was analyzed to study impact gene expression overall survival (OS). A novel murine model HPV+ HNSCC used radiotherapy activation,...

Sinonasal squamous cell carcinoma (SNSCC) is the most common malignancy of paranasal sinuses. Surgery mainstay treatment, yet positive surgical margins (PSM) are and prognostic impact on overall survival (OS) mixed. Given heterogeneity PSM OS within literature, we hypothesized that extent tumor extirpation (microscopic vs macroscopic PSM) may play a role in OS.Patients with SNSCC were identified National Cancer Database (NCDB, n = 7808). Of these, 4543 patients underwent surgery, 3265...

The effect of concussions on professional athletes has been investigated in many sports. However, few studies have evaluated National Basketball Association (NBA) players.We hypothesized that concussion incidence increased, yet the return-to-play (RTP) rate will remain high following institution NBA policy (NBACP). We also repeat be similar to first occurrences and player performance game availability not significantly affected by sustaining a concussion.Descriptive epidemiology...

Background Excessive postoperative opioid prescription is a source of diversion in the United States crisis and may contribute to chronic use. Efficient by surgeon can mitigate abuse improve pain control. In this study we sought better characterize incidence predictive baseline characteristics associated with need for additional after endoscopic sinus surgery (ESS) rhinosinusitis. Methods A retrospective review was performed on subjects undergoing ambulatory ESS between November 2016 August...

Objectives Socioeconomic factors affect oncologic outcome in sinonasal squamous cell carcinoma (SNSCC). However, the relationship between these and stage at presentation (SAP)—a critical, early point care cycle—is not known. This study sought to determine role of race/ethnicity, treatment facility type, insurance status/carrier, other socioeconomic SAP survival among patients with advanced SNSCC. Study Design Retrospective cohort study. Methods Using National Cancer Database, 6,155 SNSCC...

Socioeconomic and demographic factors have a significant impact on healthcare utilization surgical outcomes. The effect of these variables baseline symptom severity quality life (QOL) after endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) is not well established. Our goal was to investigate the association sociodemographic QOL before ESS, as reflected by 22-item Sino-Nasal Outcome Test (SNOT-22) score.Retrospective case series.From October 2016 August 2018, 244 patients with...

Objective The incidence and survivorship of human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC) are increasing. Presence HPV DNA epigenetic alterations in salivary rinses independently associated with clinical prognosis. We evaluated the utility a combined panel detecting disease recurrence during surveillance. also assessed assay’s applicability screening for HPV+ OPSCC. Study Design Retrospective cohort study. Setting Two tertiary academic hospitals....

Background Endoscopic sinus surgery (ESS) is generally well tolerated, yet a subset of patients require an additional opiate prescription in the postoperative period. The purpose this study was to quantify differences both preoperative and immediate 22‐item Sino‐Nasal Outcome Test (SNOT‐22) scores between with single those requiring prescriptions (AOPs). Methods Patients undergoing ESS November 2016 August 2017 were reviewed retrospectively. Medical Controlled Substance Utilization Review...

Cochlear implants (CIs) are a well-established treatment modality for hearing loss due to neurofibromatosis type 2 (NF2). Our aim is investigate variables that affect longitudinal performance of CIs among patients with NF2.

Clinical follow-up after endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) allows assessment of the sinonasal cavity, debridement, and tailoring medical therapies. Frequency timing postoperative clinical visits is debated, but impact adherence on disease-specific outcomes not well understood. In this longitudinal study, we assessed association between quality life (QOL) in 12 months ESS.A retrospective review patients undergoing ambulatory ESS CRS 11/2016 1/2018 was performed....

Single sided deafness (SSD) results in profound cortical reorganization that presents clinically with a significant impact on sound localization and speech comprehension. Cochlear implantation (CI) has been approved for two manufacturers' devices the United States to restore bilateral function SSD patients up 10 years of auditory deprivation. However, there is great variability performance it remains unclear how deprivation affects CI benefits within this 10-year window. This prospective...

Introduction Postoperative pain management and opioid use following endoscopic skull base surgery (ESBS) is not well understood. A subset of patients requires additional prescription (AOP) in the postoperative period. The objective this study to describe incidence AOP, as evaluate patient surgical characteristics that may predict requirements ESBS. Methods retrospective review cases undergoing ESBS between November 2016 August 2018 was performed. We reviewed patients' sociodemographic...

The round window membrane (RWM) presents a significant barrier to the local application of therapeutics inner ear. We demonstrate benchtop preclinical RWM model and evaluate superparamagnetic iron oxide nanoparticles (SPIONs) as vehicles for magnetically assisted drug delivery.

Efficient and minimally invasive drug delivery to the inner ear is a significant challenge. The round window membrane (RWM), being one of few entry points ear, has become vital focus investigation. However, due complexities isolating RWM, our understanding its pharmacokinetics remains limited. RWM comprises three distinct layers: outer epithelium, middle connective tissue layer, epithelial each potentially possessing unique properties. Current models for investigating transport across...

Efficient and minimally invasive drug delivery to the inner ear is a significant challenge. The round window membrane (RWM), being one of few entry points ear, has become vital focus investigation. However, due complexities isolating RWM, our understanding its pharmacokinetics remains limited. RWM comprises three distinct layers: outer epithelium, middle connective tissue layer, epithelial each potentially possessing unique properties. Current models for investigating transport across...

<sec> <title>BACKGROUND</title> Within the surgical field, there has been an evolution in application of robotic technology. Semi-autonomous systems and augmented visualization tools are being introduced may eventually replace existing extenders, such as da Vinci system. However, little is known about public perception these newer technologies within medical care. </sec> <title>OBJECTIVE</title> The aim this study to investigate perceptions toward surgeries with varying levels autonomy...

Objectives Transoral laser microsurgery (TLMS) and radiotherapy (XRT) are mainstays of treatment for early glottic carcinoma (EGC). Here, we investigated case‐dependent provider preferences identify factors which impact decision‐making in EGC. Methods This cross‐sectional survey laryngologists, head‐and‐neck surgeons, radiation oncologists presented five diagrammatic cases progressively advanced EGC (T1/2, N0). Respondents indicated preference TLMS or XRT ranked influenced their...

Abstract Objective This study aimed to estimate the size of United States candidacy pool meeting expanded Center for Medicare Services criteria cochlear implantation. Study Design Retrospective cross‐sectional. Setting Tertiary care center. Methods Preimplantation audiometric data from 486 patients seen at a single academic medical center were collected retrospectively and used generate predictive model AzBio score based on pure tone thresholds. was then nationally representative...

Background Endoscopic dacryocystorhinostomy (EN-DCR) is an increasingly common procedure performed by otolaryngologists. While EN-DCR has a high rate of success at relieving blockage the lacrimal system, little known regarding associated postoperative infection (POI) rates and risk factors. Objective The purpose this study was to identify factors with occurrence orbital rhinologic in large cohort patients undergoing EN-DCR. Methods A retrospective review 582 who underwent performed. All...

Background Concha bullosa (CB) is a prevalent anatomic variant and frequent surgical target in endoscopic sinus surgery (ESS). However, whether CB impacts quality-of-life (QOL) chronic rhinosinusitis (CRS) not well established. The purpose of this study was to investigate baseline post-ESS QOL differences patients with medically recalcitrant CRS without CB. Methods Demographic characteristics, postoperative 22-item Sino-Nasal Outcome Test (SNOT-22) scores for 137 who underwent primary ESS at...

Objectives/Hypothesis A subset of patients will undergo revision endoscopic sinus surgery (ESS) with a different otolaryngologist than the one who performed their primary surgery. The purpose this study is to report incidence and clinicodemographic factors associated change in surgeon for ESS. Study Design Retrospective cohort study. Methods Adult underwent at least two outpatient ESS procedures between 2009 2014 using State Ambulatory Surgery Database Florida were included Change was...