A5015027771- Liver Diseases and Immunity
- T-cell and B-cell Immunology
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Pregnancy and Medication Impact
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Macrophage Migration Inhibitory Factor
- Hepatitis C virus research
- Pediatric Hepatobiliary Diseases and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease and Transplantation
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Reproductive System and Pregnancy
University of Birmingham
2020-2025
NIHR Birmingham Biomedical Research Centre
2020-2024
NIHR Birmingham Liver Biomedical Research Unit
2020-2022
Queen Elizabeth Hospital
2021
University Hospitals Birmingham NHS Foundation Trust
2021
National Health Service
2021
National Institute for Health Research
2021
Abstract The presence of CD8 + T cells in the cytoplasm biliary epithelial (BEC) has been correlated with damage associated primary cholangitis (PBC). Here, we characterise mechanism cell invasion into BEC. observed within BEC were large, eccentric, and expressed E-cadherin, CD103 CD69. They also not contained secondary vesicles. Internalisation required cytoskeletal rearrangements which facilitated contact Internalised both non-cirrhotic cirrhotic diseased liver tissues but enriched PBC...
Autoimmune hepatitis (AIH) is an immune-mediated chronic liver disease that affects all ages, including women of childbearing age. Optimal management during pregnancy poorly defined. We aimed to explore the clinical and biochemical course AIH in antenatal postpartum periods, assess factors associated with premature birth flares. Pregnant reviewed autoimmune clinic at Queen Elizabeth Hospital Birmingham between 2009 2020 were identified retrospectively, clinical, biochemical, immunological...
The liver is a complex immunological organ. It has both immunogenic and tolerogenic capacity. Tolerogenic potential of human with its protective firewalls required to guard the body against continuous influx microbial product from gut via sinusoids biliary tree. Immunotolerance anergic state maintained by combined effort immune cells, parenchyma epithelial endothelial cells. Despite this, an unknown trigger can ignite pathway towards breakdown in hepatic tolerance leading autoimmune...
Abstract The presence of CD8+ T cells in the cytoplasm biliary epithelial (BEC) has been correlated with damage associated Primary Biliary Cholangitis (PBC). Here, we characterise mechanism cell entry into BEC. observed within BEC were large, eccentric, and expressed E-cadherin, CD103 CD69. Internalisation required cytoskeletal rearrangements which facilitated contact Internalised both non-cirrhotic diseased liver tissues but enriched PBC patients. E-cadherin expression by frequency...