A5009329097- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- RNA Research and Splicing
- Angiogenesis and VEGF in Cancer
- CRISPR and Genetic Engineering
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Hippo pathway signaling and YAP/TAZ
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- 14-3-3 protein interactions
Murdoch University
2020-2023
Perron Institute for Neurological and Translational Science
2018-2023
Vellore Institute of Technology University
2017
No exon-skipping with antisense oligos despite high thermal stability? Consider adding phosphorothioates (PS) into the sequence.
Alpha-l-Locked nucleic acid (α-l-LNA) is a stereoisomeric analogue of locked (LNA), which possesses excellent biophysical properties and also exhibits high target binding affinity to complementary oligonucleotide sequences resistance nuclease degradations. Therefore, α-l-LNA nucleotides could be utilised develop stable antisense oligonucleotides (AO), can truncated without compromising the integrity efficacy AO. In this study, we explored potential nucleotides-modified modulate splicing by...
Cancer is one of the leading causes death globally. Epidermal growth factor receptor proteins involved in cancer cell proliferation, differentiation, and invasion. Antisense oligonucleotides are chemical nucleic acids that bind to target messenger ribonucleic acid modulate its expression. Herein, we demonstrate efficacy splice-modulating antisense specific exons extracellular (exon 3) intracellular 18, 21) domains epidermal receptor. These were synthesized as 25mer 2'-O methyl...
The 14-3-3ζ protein acts as a molecular switch in regulating the TGF-β pathway, which alters from tumor suppressor early stage of breast cancer to promoter metastasis late stage.