A5080128121- Computational Drug Discovery Methods
- Antibiotics Pharmacokinetics and Efficacy
- Protein Structure and Dynamics
- Protein Interaction Studies and Fluorescence Analysis
- RNA and protein synthesis mechanisms
- Pneumonia and Respiratory Infections
- Glycosylation and Glycoproteins Research
- Enzyme Structure and Function
- Vitamin D Research Studies
- Hippo pathway signaling and YAP/TAZ
- Asthma and respiratory diseases
- Escherichia coli research studies
- Carbohydrate Chemistry and Synthesis
- Tuberculosis Research and Epidemiology
- Lysosomal Storage Disorders Research
- Drug Transport and Resistance Mechanisms
- Ferroptosis and cancer prognosis
- Sarcoidosis and Beryllium Toxicity Research
- Gene expression and cancer classification
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Research on Leishmaniasis Studies
- Antibiotic Resistance in Bacteria
- Immune Response and Inflammation
- Genetic factors in colorectal cancer
Vellore Institute of Technology University
2017-2024
Apollo Institute of Medical Sciences & Research
2024
Tuberculosis, a transmittable killer disease caused by Mycobacterium tuberculosis whose pathogenesis is poorly understood. The treatment available for the anti-mycobacterial activity has poor observance because of uprising drug resistance strains resulted prolonged giving chance to microbe develop resistance. Hence, there an urgent need identify novel compounds from marine sources which are having antimicrobial activity. GABA-AT important enzyme involved in GABA shunt pathway TCA cycle role...
The 14-3-3ζ protein acts as a molecular switch in regulating the TGF-β pathway, which alters from tumor suppressor early stage of breast cancer to promoter metastasis late stage.
Point mutation D54K in the human N-terminal caspase recruitment domain (CARD) of nucleotide-binding oligomerization −1 (NOD1) abrogates an imperative downstream interaction with receptor-interacting protein kinase (RIPK2) that entails combating bacterial infections and inflammatory dysfunction. Here, we addressed molecular details concerning conformational changes patterns (monomeric-dimeric states) by signature-based dynamics simulation. Initially, sequence analysis prioritized as a...
The missense mutation in the mismatch repair gene MSH2 underlies several hereditary cancers. In this study, we have detailed disruptive of G322D that overtly pathogenic and clinically relevant to triple negative breast cancer (TNBC) on basis structural aspect untangle unknown factors. We systematically evaluated conformational changes undergo upon from annotation intra-residual contacts, secondary arrangements fold recognition through molecular dynamics simulation. At first, interpreted...
Abstract Carbapenem‐resistant Acinetobacter baumannii , a predominant nosocomial pathogen in hospitals of intensive care units, is associated with bacteremia and ventilator‐associated pneumonia high‐risk mortality rate. To increase the effectiveness β‐lactam (BL) antibiotics, use β‐lactamase inhibitors (BLI) acts as booster when given combination BL antibiotics. this aspect, we selected antibiotics cefiderocol, cefepime, non‐BL antibiotic eravacycline, BLI durlobactam, avibactam, enhancer...
Aspartylglucosaminuria (AGU) is a lysosomal storage disorder caused by insufficient aspartylglucosaminidase (AGA) activity leading to chronic neurodegeneration. We utilized the PhosphoSitePlus tool identify AGA protein's phosphorylation sites. The was induced on specific residue of three-dimensional protein, and structural changes upon were studied via molecular dynamics simulation. Furthermore, behaviour C163S mutation with adjacent investigated. have examined impact phosphorylated forms in...
Diabetes Mellitus is a complex metabolic disorder with one of the highest prevalence rates in world. The present study probes into Thr-Ala 642 mutation Akt substrate 160 kDa (AS160) which has been implicated diabetes by dysregulation glucose transported vesicle 4 (GLUT4) translocation. Our provides possible evidence on structural basis dysfunction AS160 and how association phosphorylated 14-3-3, downstream binding partner regulating GLUT4 translocation got disrupted due to T642A mutation. We...
The human NBD domain which is centrally located in the NOD2 protein displays an essential role oligomerization and initiates immune response via CARD-RIPK2 interaction. mutations associated with have been largely implicated inflammatory disorders such as Blau syndrome sarcoidosis. This study aims to determine structural phenotypic effect of a lethal mutation that occurs has axiomatic impact on dysfunction. Initially, most deleterious missense were screened through various silico analysis....