A5046492136- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Photoreceptor and optogenetics research
- Retinoids in leukemia and cellular processes
- Neuroinflammation and Neurodegeneration Mechanisms
- Connexins and lens biology
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Cellular Mechanics and Interactions
- Cardiovascular Health and Risk Factors
- Retinopathy of Prematurity Studies
- Sphingolipid Metabolism and Signaling
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Biosensors and Analytical Detection
- Caveolin-1 and cellular processes
- Neuropeptides and Animal Physiology
- Ion Transport and Channel Regulation
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Protein Tyrosine Phosphatases
- Photochromic and Fluorescence Chemistry
- Graphene and Nanomaterials Applications
- Retinal and Optic Conditions
Centro de Investigaciones Biológicas Margarita Salas
2011-2022
Universidad de Alcalá
2006-2019
Consejo Superior de Investigaciones Científicas
2014-2017
Abstract Growing evidence suggests that inflammation is involved in the progression of retinitis pigmentosa (RP) both patients and animal models. The aim this study was to investigate effect Adalimumab, a monoclonal anti-TNFα antibody, on retinal degeneration murine model human autosomal recessive RP, rd10 mice at postnatal day (P) 18. In our housing conditions, retinas were seriously damaged P18. Adalimumab reduced photoreceptor cell death, as determined by scoring number TUNEL-positive...
Abstract ProNGF signaling through p75 NTR has been associated with neurodegenerative disorders. Retinitis pigmentosa (RP) comprises a group of inherited retinal dystrophies that causes progressive photoreceptor cell degeneration and death, at rate dependent on the genetic mutation. There are more than 300 mutations causing RP, this is challenge to therapy. Our study was designed explore common mechanism for in progression assess its potential value as therapeutic target. The proNGF/p75...
A novel suspended planar-array chips technology is described, which effectively allows molecular multiplexing using a single chip to analyze extraordinarily small volumes. The are fabricated by combining silicon-based and polymer-pen lithography, obtaining increased pattern flexibility, improving miniaturization parallel production. so dramatic that it permits the intracellular analysis of living cells. Advances in biomolecular studies benefit enormously from biological assays.1, 2...
Current advances in materials science have demonstrated that extracellular mechanical cues can define cell function and fate. However, a fundamental understanding of the manner which intracellular affect mechanics remains elusive. How hindrance, reinforcement, supports interfere with cycle promote death is described here. Reproducible devices highly controlled size, shape, broad range stiffness are internalized HeLa cells. Once inside, they induce characteristic cell-cycle deviations death....
Synaptic loss, neuronal death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Retinitis pigmentosa (RP), the leading cause inherited blindness, is a group retinal dystrophies characterized by photoreceptor dysfunction death. The insulin receptor, key controller metabolism, also regulates survival synaptic formation, maintenance, activity. Indeed, deficient receptor signaling has been implicated in several brain pathologies. We present...
Abstract Antipsychotics are established drugs in schizophrenia treatment which, however, not free of side effects. Lipid rafts critical for normal brain function. Several G protein‐coupled receptors, such as somatostatin (SRIF) have been shown to localize lipid rafts. The aim this study was investigate whether haloperidol affects the composition and functionality SH‐SY5Y neuroblastoma cells. Haloperidol inhibited cholesterol biosynthesis, leading a marked reduction cell content an...
The aim of this study was to elucidate whether sulfadiazine, shown improve cognitive capacity in the elderly, can prevent amyloid beta peptide (Aβ) (25–35)-induced impairment somatostatinergic system previously reported by our group rat temporal cortex. Male Wistar rats were thus treated with sulfadiazine (160 mg/kg) or vehicle, via a gastric cannula, twice on day prior Aβ(25–35) treatment. On following and during 14 days, administered intracerebroventricularly (i.c.v.) an osmotic minipump...