A5015337199- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiovascular Effects of Exercise
- Tracheal and airway disorders
- Hip and Femur Fractures
- Cardiac tumors and thrombi
- Potassium and Related Disorders
- Diabetes Treatment and Management
- COVID-19 and healthcare impacts
- Vascular Procedures and Complications
- Sarcoma Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Cardiac Ischemia and Reperfusion
Northwestern Medicine
2018-2024
Northwestern University
2014-2024
Northwestern Memorial Hospital
2015-2024
Northwestern University
2024
Cardiovascular Institute of the South
2018-2021
San Diego Cardiac Center
2021
Valve (United States)
2021
University of Minnesota
2016
University of Virginia
2007-2016
Virginia Commonwealth University
2010-2013
Rationale: Ischemia–reperfusion (IR) injury after lung transplantation, which affects both short- and long-term allograft survival, involves activation of NADPH oxidase 2 (NOX2) invariant natural killer T (iNKT) cells to produce IL-17. Adenosine A2A receptor (A2AR) agonists are known potently attenuate IR IL-17 production. However, mechanisms for iNKT cell A2AR agonist–mediated protection remain unclear.Objectives: We tested the hypothesis that NOX2 mediates production by agonism prevents...
Bicuspid aortic valve (BAV) disease is associated with increased risk of aortopathy. In addition to current intervention guidelines, BAV mediated changes in 3D hemodynamics have been considered as stratification measures. We aimed evaluate the association 4D flow cardiovascular magnetic resonance (CMR) derived voxel-wise reverse dilation and investigate role regurgitation (AR) stenosis (AS) on systole diastole.
The purpose of our study was to assess the value true lumen and false hemodynamics compared aortic morphological measurements for predicting adverse-aorta related outcomes (AARO) growth in patients with type B dissection (TBAD).Using an IRB approved protocol, we retrospectively identified descending aorta (DAo) at a large tertiary center. Inclusion criteria includes known TBAD ≥ 6 months clinical follow-up after initial presentation or ascending intervention repaired A residual (rTAAD)....
Background 4D Flow MRI is a quantitative imaging technique to evaluate blood flow patterns; however, it unclear how compressed sensing (CS) acceleration would impact aortic hemodynamic quantification in type B dissection (TBAD). Purpose To investigate CS‐accelerated performance compared GRAPP‐accelerated (GRAPPA) hemodynamics TBAD. Study Type Prospective. Population Twelve TBAD patients, two volunteers. Field Strength/Sequence 1.5T, 3D time‐resolved cine phase‐contrast gradient echo...
Abstract Background Alkaptonuria is a rare metabolic disease that causes an increase in homogentisic acid (HGA) due to lack of enzymatic activity. Commonly, accumulation HGA presents with dark discoloration skin and other tissues, also known as ochronosis. Additionally, alkaptonuria can result clinical manifestations, including arthritis cardiac disease. This case highlights alkaptonuria-related challenges surgery teams may face when treating this patient population. Case summary A...
Background: The desire of patients to avoid anticoagulation, together with the potential valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR), have resulted in increasing use bioprosthetic valves for (AVR). While patient-prosthesis mismatch (PPM) is known be an adverse risk after AVR, few studies addressed effect PPM on durability. This study evaluates role size and hemodynamics long term durability AVR a Magna bioprosthesis. Methods: We performed retrospective, single-center...
Background Aortopathy is common with bicuspid aortic valve (BAV), and underlying intrinsic tissue abnormalities are believed causative. Valve‐mediated hemodynamics altered in BAV may contribute to aortopathy its progression. The contribution of defects versus progression not known. Purpose To investigate relative contributions tissue‐innate aortopathy. Study Type Retrospective. Subjects Four hundred seventy‐three patients dilatation (diameter ≥40 mm; comprised 281 varied AS severity, 192...
Stanford type B aortic dissection (TBAD) is a potentially fatal condition involving tear in the descending aorta. As TBAD can be managed with medical therapy or surgical repair, identifying predictors of adverse outcomes important to risk-stratify patients for preemptive procedures. 4D flow magnetic resonance imaging (MRI) has shown useful characterizing complex hemodynamics seen and correlating patterns outcomes. We report case 58-year-old man who presented hospital acute large primary...