A5078818236- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Photoreceptor and optogenetics research
- Optical Imaging and Spectroscopy Techniques
- Neuroscience and Neural Engineering
- Traumatic Brain Injury and Neurovascular Disturbances
- Thermal Regulation in Medicine
- Neurotransmitter Receptor Influence on Behavior
- Psychology of Moral and Emotional Judgment
- Amyotrophic Lateral Sclerosis Research
- Receptor Mechanisms and Signaling
- Epilepsy research and treatment
- Amphibian and Reptile Biology
- Neurogenesis and neuroplasticity mechanisms
- Animal Behavior and Reproduction
- Laser-induced spectroscopy and plasma
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Heart Rate Variability and Autonomic Control
- Cultural Differences and Values
- Laser-Ablation Synthesis of Nanoparticles
UK Dementia Research Institute
2019-2024
University College London
2019-2024
Virginia Commonwealth University
2023-2024
University of London
2022-2023
Invitae (United States)
2023
Baptist Memorial Hospital
2023
Goethe University Frankfurt
2021
German Center for Neurodegenerative Diseases
2021
Columbia University Irving Medical Center
2021
University of Sheffield
2010-2019
Abstract People often discount evidence that contradicts their firmly held beliefs. However, little is known about the neural mechanisms govern this behavior. We used neuroimaging to investigate systems involved in maintaining belief face of counterevidence, presenting 40 liberals with arguments contradicted strongly political and non-political views. Challenges beliefs produced increased activity default mode network—a set interconnected structures associated self-representation...
The difference between believing and disbelieving a proposition is one of the most potent regulators human behavior emotion. When accepts statement as true, it becomes basis for further thought action; rejected false, remains string words. purpose this study was to differentiate belief, disbelief, uncertainty at level brain.We used functional magnetic resonance imaging (fMRI) brains 14 adults while they judged written statements be "true" (belief), "false" (disbelief), or "undecidable"...
While religious faith remains one of the most significant features human life, little is known about its relationship to ordinary belief at level brain. Nor it whether believers and nonbelievers differ in how they evaluate statements fact. Our lab previously has used functional neuroimaging study as a general mode cognition [1], others have looked specifically [2]. However, no research compared these two states mind directly.We magnetic resonance imaging (fMRI) measure signal changes brains...
Abstract Dipeptide repeat proteins are a major pathogenic feature of C9orf72 amyotrophic lateral sclerosis (C9ALS)/frontotemporal dementia (FTD) pathology, but their physiological impact has yet to be fully determined. Here we generated dipeptide knock-in mouse models characterized by expression 400 codon-optimized polyGR or polyPR repeats, and heterozygous reduction. (GR)400 (PR)400 mice recapitulate key features C9ALS/FTD, including cortical neuronal hyperexcitability, age-dependent spinal...
Reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer's disease (AD), but the underlying assumption that neurons are main source pathogenic Aβ is untested. Here, we challenge this prevailing belief by demonstrating oligodendrocytes an important human brain and play a key role promoting abnormal neuronal hyperactivity AD knock-in mouse model. We show selectively suppressing oligodendrocyte production improves pathology restores function model vivo. Our findings...
It is generally recognised that event related potentials (ERPs) of electroencephalogram (EEG) primarily reflect summed post-synaptic activity the local pyramidal neural population(s). However, it still not understood how positive and negative deflections (e.g. P1, N1 etc) observed in ERP recordings are to underlying excitatory inhibitory activity. We investigated neurogenesis P1 ERPs by pharmacologically manipulating somatosensory cortex rodent, concurrently recording EEG field (LFPs). found...
Understanding neurovascular coupling is a prerequisite for the interpretation of results obtained from modern neuroimaging techniques. This study investigated hemodynamic and neural responses in rat somatosensory cortex elicited by 16 seconds electrical whisker stimuli. Hemodynamics were measured optical imaging spectroscopy activity multichannel electrophysiology. Previous studies have suggested that whisker-evoked response contains two mechanisms, transient ‘backwards’ dilation middle...
Abstract Neural activity is closely followed by a localised change in cerebral blood flow, process termed neurovascular coupling. These hemodynamic changes form the basis of contrast functional magnetic resonance imaging (fMRI) and are used as correlate for neural activity. Anesthesia widely employed animal fMRI studies, however anesthetics known to profoundly affect vascular physiology, particularly mice. Therefore, we investigated efficacy novel ‘modular’ anesthesia that combined...
Laser synthesis in liquids is often carried out organic solvents to prevent oxidation of metals during nanoparticle generation and produce tailored carbon-based nanomaterials. This work investigates laser ablation neat acetone, ethanol, n-hexane, toluene with pulse widths ranging from 30 fs 4 ps through measurements reaction kinetics characterization the products optical spectroscopy mass spectrometry. Increasing width impacts both product distributions, suppressing formation solvent...
Pulsed laser ablation in organic solvents is widely used to produce oxide-free metal and carbide nanoparticles, often with carbon coatings resulting from laser-induced reactions the solvent. To gain insight into how molecular structure of solvent affects these reaction pathways, this work investigates C
Studies that use prolonged periods of sensory stimulation report associations between regional reductions in neural activity and negative blood oxygenation level-dependent (BOLD) signaling. However, the generators BOLD response remain to be characterized. Here, we single-impulse electrical whisker pad anesthetized rat identify components are related “negative” hemodynamic changes brain. Laminar multiunit local field potential recordings were performed concurrently with two-dimensional...
Reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer’s Disease (AD), but the underlying assumption that neurons are main source pathogenic Aβ is untested. Here we challenge this prevailing belief by demonstrating oligodendrocytes an important Aβ, and play a key role promoting abnormal neuronal hyperactivity AD. We show selectively suppressing oligodendrocyte production improves AD brain pathology restores function vivo . Our findings suggest targeting could...
In vivo calcium imaging is an incredibly powerful technique that provides simultaneous information on fast neuronal events, such as action potentials and subthreshold synaptic activity, well slower events occur in the glia surrounding neuropil. Bulk-loading methods involve multiple injections can be used for single-cell wide-field studies. However, result inhomogeneous loading sites of potential cortical injury. We convection-enhanced delivery to create smooth, continuous a large area...
Characterization of neural and hemodynamic biomarkers epileptic activity that can be measured using non-invasive techniques is fundamental to the accurate identification epileptogenic zone (EZ) in clinical setting. Recently, oscillations at gamma-band frequencies above (>30 Hz) have been suggested provide valuable localizing information EZ track cortical activation associated with processes. Although a tight coupling between hemodynamic-based signals has consistently demonstrated...
Abstract Neurovascular coupling (NVC) is a mechanism that, amongst other known and latent critical functions, ensures activated brain regions are adequately supplied with oxygen glucose. This biological phenomenon underpins non-invasive perfusion-related neuroimaging techniques recent reports have implicated NVC impairment in several neurodegenerative disorders. Yet, much remains unknown regarding health disease, only recently has there been burgeoning recognition of close interplay...
Abstract Although promise exists for patterns of resting‐state blood oxygen level‐dependent ( BOLD ) functional magnetic resonance imaging fMRI brain connectivity to be used as biomarkers early pathology, a full understanding the nature relationship between neural activity and spontaneous fluctuations is required before such data can correctly interpreted. To investigate this issue, we combined electrophysiological recordings rapid changes in multi‐laminar local field potentials from...
Summary Objective Whether epileptic events disrupt normal neurovascular coupling mechanisms locally or remotely is unclear. We sought to investigate in an acute model of focal neocortical epilepsy, both within the seizure onset zone and contralateral homotopic cortex. Methods Neurovascular ipsilateral vibrissal cortices urethane‐anesthetized rat were examined during recurrent 4‐aminopyridine (4‐ AP , 15 m 1 μl) induced seizures. Local field potential ( LFP ) multiunit spiking activity MUA...
ORIGINAL RESEARCH article Front. Neuroenergetics, 11 August 2010 https://doi.org/10.3389/fnene.2010.00015