A5073146875- Multiple and Secondary Primary Cancers
- Colorectal Cancer Surgical Treatments
- Renal cell carcinoma treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Prostate Cancer Diagnosis and Treatment
- Healthcare Systems and Public Health
- Urologic and reproductive health conditions
- Cancer Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Prostate Cancer Treatment and Research
- Medical and Agricultural Research Studies
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Melanoma and MAPK Pathways
- Urinary and Genital Oncology Studies
- Advanced Breast Cancer Therapies
- Diverticular Disease and Complications
- Pelvic floor disorders treatments
- CAR-T cell therapy research
- Male Breast Health Studies
- Enhanced Recovery After Surgery
Budgetary Health Care Institution of the Omsk Region "Clinical Oncology Center"
2014-2024
State Healthcare Institution "Regional Clinical Oncological Dispensary"
2016-2023
Siberian State University of Physical Education and Sport
2020-2022
Preclinical data suggest the combination of an anti-programmed death receptor 1 antibody plus dabrafenib and trametinib to have superior antitumor activity compared with alone. These observations are supported by translational evidence suggesting that immune checkpoint inhibitors targeted therapy may improve treatment outcomes in patients BRAF V600-mutant metastatic melanoma. COMBI-i is a phase III trial evaluating spartalizumab, antibody, (sparta-DabTram), versus placebo (placebo-DabTram)...
9527 Background: Combination of immune checkpoint inhibitors and targeted therapy may produce durable deep response in a higher proportion pts with BRAF V600–mutant unresectable or metastatic melanoma. A recent report from the randomized, double-blind, placebo (PBO)-controlled Part 3 Phase COMBI-i trial (NCT02967692) failed to show statistically significant progression-free survival (PFS) benefit (hazard ratio (HR) 0.82 (95% CI, 0.66‒1.03, p=.042)). Here, we 3-year OS data part 3. Methods:...
Objective : to investigate the severity of stress response organism during surgery on colon because a tumor by determining level hormones and glucose depending various types anesthesia. Materials methods . Patients who have undergone resection malignancy were divided into two groups: study group (n=57) comparison (n=35). In multimodal anesthesia was performed that included shallow sympathetic blockade in combination with surface inhalation inhalationintravenous basis systemic administration...
Aim. The aim of the study was to evaluate surgical treatment outcomes in a regional oncology dispensary and postoperative complications risk factors evaluation. Materials methods. retrospective included clinical data patients with verified colon carcinoma who underwent radical surgery. were assessed. Results. 968 wes analyzed. Complicated cancer observed 10.2 % patients. Postoperative mortality 0.6 %. Mortality almost significantly lower under 75 years old ( p = 0.06) OR 0.092 (95 CI...
Treatment of benign prostatic hyperplasia is an important and challenging problem modern medicine. One the most methods treatment this disease artery embolization. This procedure often done through transfemoral approach. Transradial vascular access has many advantages over access. Our study presents a comparative analysis use transradial approach in type interventions. was used 13 patients, - 12 patients. The success 100% both groups. total duration procedure, time needed for catheterization...
The study was carried out to evaluate timeliness of detection cervix malignant neoplasms against the background supply necessary manpower in region. indices active neoplasm and its stages, degree neglect tumor process lethality during first year diagnosed disease are considered. enumerated correlated with quality medical services шт part availability characteristics training available personnel. comparison data Omsk region average national implemented. corresponding municipal districts...
Background. The design and introduction of novel medicaments into clinical practice has confirmed that it is necessary to search for new prognostic factors re-evaluate the biological properties a tumor identify subgroup patients who will benefit from drug treatment. An individual approach personalization performed therapy be able substantially enhance its efficiency. Subjects methods. Thirty-four oncology urology research health care institutions 8 federal districts Russian Federation took...
The article presents the results of treatment 85 fertile age women with breast fibroadenomas. They were operated either by partial mastectomy or vacuum aspiration removal fibroadenomas En-Cor apparatus. study evaluated therapeutic effect on hormonal background achieved monophase microdose complex oral contraceptives (ethinyl estradiol at dose 20 pg) aspiration. use apparatus was effective not only in total fibroadenoma removal, but also excellent cosmetic results, reduction operation time,...
Background . Intraoperative rectal injury in patients undergoing prostatectomy is a severe complication, worsens the quality of life and leads to social maladjustment. Objective To develop, substantiate reproducibility safety technique for formation fascial duplication elimination damage anterior wall during prostatectomy. Materials methods The authors present description their own experience retropubic with 2 prostate cancer. Patients intermediate risk recurrence progression according...
Objective : to develop and substantiate the method of stabilization urethrovesical anastomosis with retropubic prostatectomy improve results early recovery urinary retention. Materials methods . 58 patients who had undergone radical were enrolled into prospective study. The patient population was divided two groups by blinded randomization. first control group consists 29 men underwent traditional routine surgical treatment. second main (29 patients) novel treatment making...
Background. Laparoscopic surgery becomes a standard treatment for many surgical diseases. Defects of stapler laparoscopic mechanical suture during the formation an anastomosis after hemicolectomy are detected in 18% observed cases. Objective. Development, substantiate reproducibility and safety manual intracorporeal term-terminal invagination ileotransverse method performing right hemicolectomy. Material Methods. Authors presented description technique their own experience on with original...
Purpose — to carry out a comparative assessment of inflammation based on evaluation intraoperative and early postoperative dynamics blood serum cytokines in pulmonary malignant neoplasm patients different anesthesia analgesia settings. Material methods. 24 45 50 years age divided into 2 groups were examined. All suffered from verified new onset neoplasms without true signs metastases. Tumor differentiation by morphology was not undertaken since that beyond the study design. Patients did...
Aim : to evaluate the results of original manual intracorporeal end-to-end invagination ileotransverse anastomosis after laparoscopic right hemicolectomy. Patients and methods twenty-two patients with colon cancer were included in study: 17 females 5 males aged 53.1±3.4 years. They underwent hemicolectomy standard D2 lymphadenectomy by technique. Follow-up period surgery was 3 months. Results no conversions open occurred. The operation time 120.0±12.5 minutes, median blood loss 87.0±5.0 ml....
Objective. To prove pathogenically the reasonability of multimodal anesthesia in patients with lung cancer to improve efficacy pain management. Materials and methods . 74 (59 men 15 women) aged 46 60 years were examined treated. 42 (the main group) underwent surgery under accompanied epidural blockade, 32 comparison subjected a surgical intervention inhalation intravenous mechanical ventilation. The surgeries including atypical resection, lobectomy pneumonectomy performed. In preoperative,...
The incidence of polyneoplasia was studied among the urban and rural populations Omsk Region. Urinary tract neoplasms constitute 10% total structure cancer morbidity, these occurring twice more frequently in population than one. Polyneoplasias involving urinary are metachronous 62.8%, synchronous 35.2%, metachronous-and-synchronous 1.2%, synchronous-and-metachronous 0.8%. Out 253 patients with tract, 176 (69.6%) died 77 (30.4%) survived during 8 years.
In order to evaluate the diagnostic efficiency of MDCT with bolus contrast enhancement in visualization renal cancer pseudocapsule a retrospective study, included 74 patients histologically confirmed renal-cell cancer, was performed. Images were acquired native, arterial, portal and nephrographic - excretory phase on 64-detector CT scanner. The accuracy detecting determined by comparison histological findings. Native axial images multiplanar reformations analyzed. According results study...
Introduction Malignant neoplasms of the liver are one most common pathologies in oncology. Chemoembolization hepatic artery is currently widely used treatment unresectable tumors. Transradial vascular access actively interventional cardiology due to fewer local complications. At same time, until recently, chemoembolization was more often performed via transfemoral access. The aim work a comparative analysis results transradial and accesses for purpose chemoembolization. Material methods data...