Abstract Selective three‐component 1,2‐diamination of 1,3‐dienes with concurrent introduction two orthogonally protected amino groups remains unknown despite its significant synthetic potential. We report herein that reaction conjugated dienes N ‐aminopyridinium salts and TMSNCS affords 1,2‐aminoisothiocyanation products in a highly chemo‐ regio‐selective manner under mild photoredox catalytic conditions. Mechanistic studies indicate the facile isomerization allyl thiocyanates to...

Dual photoredox–transition-metal catalysis has emerged as a powerful tool for the development of chemical transformations. However, its application in selective difunctionalization 1,3-dienes remains essentially unexploited. By synergistic action photoredox and copper catalysts, we report herein an enantioselective 1,2-amidocyanation 1,3-dienes. Visible-light irradiation chloroform solution conjugated dienes, N-Boc-amidopyridinium salts, TMSCN presence catalytic amount fac-Ir(ppy)3,...

In spite of the obvious synthetic potential functionalized allylic azides, only limited routes have been developed. We report herein a three-component 1,2-amidoazidation 1,3-dienes. presence fac-Ir(ppy)3 under blue LED irradiation, reaction 1-aryl substituted 1,3-dienes with N-amidopyridinium salt and trimethylsilyl azide (TMSN3) affords exclusively products. The 1-alkyl counterparts undergo same moderate to high 1,2- vs 1,4-selectivity. Reduction this mixture PPh3 dynamic kinetic conditions...

Selective C(sp3)-H isothiocyanation represents a significant strategy for the synthesis of isothiocyanate derivatives. We report herein an electrochemical benzylic in highly chemo- and site-selective manner under external oxidant-free conditions. The high chemoselectivity is attributed to facile situ isomerization thiocyanates isothiocyanates. Notably, method exhibits functional group compatibility suitable late-stage functionalization bioactive molecules.

A novel copper-catalyzed tandem C–S/C–C bond-forming reaction of 2-biaryl isothiocyanates with diaryliodonium salts was developed. This is the first general approach to synthesize phenanthridines from isothiocyanates. methodology has been successfully applied synthesis trisphaeridine.

β-Ketothioamides (KTAs) are versatile building blocks for the rapid construction of various heterocyclic compounds. In past decade, a number successful reactions based on KTAs have been developed skeletons under mild conditions. This minireview focuses annulation with dielectrophilic or dinucleophilic reagents. Multicomponent using to construct heterocycles also major contents in this review.

Various intermolecular interactions in perovskite solar cells can help improving efficiency and stability.

A scalable electrochemical reduction of sulfoxides to sulfides has been developed.

An electrochemical protocol for site-selective benzylic C(sp 3 )–H thiocyanation was developed under mild reaction conditions.

Abstract A visible‐light‐induced photocatalytic trifluoromethylthiolation/cyclization of olefinic amides using N ‐trifluoromethylthiosaccharin as the trifluoromethylthiolating reagent is described. This straightforward method applicable to a wide variety and useful SCF 3 ‐containing benzoxazines oxazolines can be prepared in moderate excellent yields under mild conditions.

Visible-light-mediated trifluoromethylthiolation of <italic>N</italic>-(<italic>o</italic>-cyanobiaryl)acrylamides with <italic>N</italic>-trifluoromethylthiosaccharin as the source SCF₃ radicals provided an efficient route to SCF₃-containing ring-fused phenanthridine derivatives.

The efficient electrochemically promoted [3 + 2] annulation of imidazo[1,2-a]pyridines with alkynes using traceless electrons as green reagents has been developed, leading to the synthesis a large class polycyclic heteroaromatics in good yields broad substrate scope under mild and conditions. scaled-up experiment, follow-up procedures, potential biological applications show practicability feasibility electrochemical method.

Abstract A direct electrochemical reductive approach for deoxygenation of alcohols has been developed in the presence substoichiometric amount AlCl3. The released Al ions from sacrificial anode could combine with chloride anion to regenerate Lewis acid.

An electrochemical thiocyanation of distal C(sp 3 )–H bonds based on amidyl radical-mediated 1,5-HAT has been developed. The transformation is highly site-selective and compatible with primary, secondary, tertiary sulfonamides, bioactive derivatives.

The direct allylic C(sp3)–H functionalization provides a straightforward protocol for the synthesis of valuable molecules. We report herein first chemo- and site-selective method isothiocyanation various internal alkenes under mild electrochemical conditions. This exhibits broad functional group tolerance excellent selectivity can be applied late-stage bioactive Combined experimental computational studies indicate that reaction proceeds via an unexpected [3,3]-sigmatropic rearrangement.

This paper reviews new strategies in electrochemical organic synthesis the Csp3-H/Csp2-H activation, cyclization, REDOX processes, and three-component reactions. Traditional methods encounter numerous challenges these areas, including harsh reaction conditions, limited substrate ranges, difficulties selective control, poor environmental sustainability. Electrochemical synthesis, as a technology, utilizes electrons reagents to precisely control process by accurately managing electrode...

A copper-catalyzed tandem arylation-cyclization process to access 1-(arylthio)isoquinolines from isothiocyanates and diaryliodonium salts is described. It the first general method construct potentially useful 1-(arylthio)isoquinoline derivatives. Moreover, 1-(methylthio)isoquinoline derivatives were also achieved successfully with MeOTf instead of under metal-free conditions. Mechanistic studies reveal that these two processes proceed in different routes. This has been applied synthesis...

A novel Mn(II)-promoted tandem phosphorylation/cyclization reaction of 2-biaryl isothiocyanates with phosphine oxides is described. This the first general method to synthesize 6-phosporylated phenanthridines from isothiocyanates. The approach featured by oxidant-free, low loading P-reagent, easy operation, and high functional group tolerance.

A Cu-catalyzed arylation–cyclization approach is developed for the synthesis of thiochromeno[2,3-<italic>b</italic>]indoles through <italic>S</italic>-arylation, 5-<italic>endo-trig</italic> cyclization, and Friedel–Crafts-type cyclization sequence.

Abstract An approach for iodofluoroalkylation of unactivated alkynes and alkenes facilitated by an earth‐abundant inexpensive manganese catalyst, Mn 2 (CO) 10 , is reported. This protocol employs visible light as the energy input shows a wide substrate scope high functional‐group compatibility. A variety synthetically useful fluoroalkylated alkyl alkenyl iodides can be prepared in moderate to excellent yields. The reaction features efficiency, operational simplicity, scalability, well...