A5052205909- Autism Spectrum Disorder Research
- Neurobiology of Language and Bilingualism
- Substance Abuse Treatment and Outcomes
- Opioid Use Disorder Treatment
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Face Recognition and Perception
- Reading and Literacy Development
- Cognitive and developmental aspects of mathematical skills
- Attention Deficit Hyperactivity Disorder
- Visual perception and processing mechanisms
- Behavioral and Psychological Studies
- Obsessive-Compulsive Spectrum Disorders
- Memory and Neural Mechanisms
- Child and Animal Learning Development
- Child Development and Digital Technology
- Language Development and Disorders
- Advanced Neuroimaging Techniques and Applications
- Prenatal Substance Exposure Effects
- Neuroscience and Music Perception
- Multisensory perception and integration
- Schizophrenia research and treatment
- EEG and Brain-Computer Interfaces
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
Autism & Developmental Medicine Institute
2016-2025
Geisinger Health System
2016-2025
Geisinger Neuroscience Institute
2019-2024
Commonwealth Medical College
2019-2024
Geisinger Medical Center
2019-2022
Temple University
2016
Children's Hospital of Philadelphia
2010-2015
University of Pennsylvania
2006-2013
Center for Autism and Related Disorders
2010-2013
Hospital of the University of Pennsylvania
2011
Hearing loss is one of the most common complaints in adults over age 60 and a major contributor to difficulties speech comprehension. To examine effects hearing ability on neural processes supporting spoken language processing humans, we used functional magnetic resonance imaging monitor brain activity while older with age-normal listened sentences that varied their linguistic demands. Individual differences predicted degree language-driven recruitment during auditory sentence comprehension...
Speech comprehension remains largely preserved in older adults despite significant age-related neurophysiological change. However, adults' performance declines more rapidly than that of young when listening conditions are challenging. We investigated the cortical network underlying speech healthy aging using short sentences differing syntactic complexity, with processing demands further manipulated through rate. Neural activity was monitored blood oxygen level–dependent functional magnetic...
Most behavioral training regimens in autism spectrum disorders (ASD) rely on reward-based reinforcement strategies. Although proven to significantly increase both cognitive and social outcomes successfully reduce aberrant behaviors, this approach fails benefit a substantial number of affected individuals. Given the enormous amount clinical financial resources devoted interventions, there is surprisingly large gap our knowledge basic reward mechanisms learning ASD. Understanding for...
Neuroimaging studies have identified brain regions that respond preferentially to specific stimulus categories, including 3 areas activate maximally during viewing of real-world scenes: The parahippocampal place area (PPA), retrosplenial complex (RSC), and transverse occipital sulcus (TOS). Although these findings suggest the existence specialized for scene processing, this interpretation is challenged by recent reports activity in scene-preferring modulated properties isolated single...
<b>Objectives:</b> Our social cognition model posits that knowledge and executive resources guide interpersonal decision making. We investigated this by examining the resolution of standardised dilemmas in patients with a disorder (SOC/EXEC) caused frontotemporal dementia (FTD). <b>Methods:</b> Patients SOC/EXEC (n = 12) those progressive aphasia (APH, n 14) completed measures requiring (Guilford's Cartoon Predictions Test), (theory mind false belief vignettes behavioural rating measure...
<h3>Importance</h3> Electronic health records are a potentially valuable source of information for identifying patients with opioid use disorder (OUD). <h3>Objective</h3> To evaluate whether proxy measures from electronic record data can be used reliably to identify probable OUD based on<i>Diagnostic and Statistical Manual Mental Disorders</i>(Fifth Edition) (<i>DSM-5)</i>criteria. <h3>Design, Setting, Participants</h3> This retrospective cross-sectional study analyzed individuals within the...
Abstract Sensory processing differences, particularly within the visual domain, are common in neurodevelopmental conditions, including autism. Studies examining hierarchical of figures containing global (i.e., gist) and local detail) elements inconsistent but converge on a theme relation to autism: slowed locally-oriented default. We examined behavioral pupillary responses adults with varying levels autistic traits during free-viewing task. Results showed that participants were both more...
The goals of the present study were twofold. First, we wished to investigate neural correlates stimulus-driven processing stimuli strongly suppressed from awareness and in absence top-down influences. We accomplished this using a novel approach which participants performed an orthogonal task atop flash suppression noise image prevent search. Second, extent amygdala responses differentiate between (fearful faces houses) based on their motivational relevance. Using continuous conjunction with...
Little is known about the network of brain regions activated prior to explicit awareness emotionally salient social stimuli. We investigated this in a functional magnetic resonance imaging study using technique that combined elements binocular rivalry and motion flash suppression order prevent fearful faces houses. found increased left amygdala fusiform gyrus activation for compared houses, despite from awareness. Psychophysiological interaction analyses showed was associated with...
The present study examined the organization of complex familiar activities, known as "scripts" (e.g., "going fishing"). We assessed whether events in a script are processed linear-sequential manner or clustered-hierarchical manner, and we evaluated neural basis for this processing capacity. Converging evidence was obtained from functional neuroimaging healthy young adults behavioral structural magnetic resonance imaging (MRI) data patients with focal neurodegenerative disease. In both...
Social animals are naturally drawn towards conspecifics: from birth onwards we orient other humans and seek social interactions. In this paper tested the hypothesis that a region in orbitofrontal cortex (OFC), previously identified by electrophysiology fMRI studies non-human primates, is preferentially sensitive to faces due their socially rewarding properties. Twenty healthy college students were scanned while viewing several categories of stimuli including rewards (faces) non-social...
The pupil is known to reflect a range of psychological and physiological variables, including cognitive effort, arousal, attention, even learning. Within autism spectrum disorder (ASD), some work has used physiology successfully classify patients with or without autism. As we have come understand the heterogeneity ASD other neurodevelopmental disorders, relationship between quantitative traits markers become increasingly more important, as this may lead us closer underlying biological basis...
Objective Among persons with opioid use disorder (OUD), co-occurring depression is linked to a greater risk of misuse, overdose and suicide. Less known about characteristics other comorbid health conditions depressive disorders.Methods This study used electronic record (EHR) encounters from the Geisinger Health System prior fall 2019. Adult patients were recruited medication-based treatment clinic had an OUD diagnosis (N = 692). Co-occurring was defined by in EHR. Multivariable logistic...
Opioid use disorder (OUD) is underdiagnosed in health system settings, limiting research on OUD using electronic records (EHRs). Medical encounter notes can enrich structured EHR data with documented signs and symptoms of social risks behaviors. To capture this information at scale, natural language processing (NLP) tools must be developed evaluated. We applied an annotation schema to deeply characterize related clinical, behavioral, environmental factors, automated the machine learning deep...