A5065005655- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Immune responses and vaccinations
- T-cell and B-cell Immunology
- Vibrio bacteria research studies
- Viral Infections and Outbreaks Research
- HIV Research and Treatment
- CRISPR and Genetic Engineering
- Cancer Immunotherapy and Biomarkers
Universidade de São Paulo
2019-2022
Dengue fever has become a global threat, causing millions of infections every year. An effective vaccine against all four serotypes dengue virus (DENV) not been developed yet. Among the different vaccination strategies available today, DNA vaccines are safe and practical, but currently induce relatively weak immune responses in humans. In order to improve immunogenicity, antigens may be targeted dendritic cells (DCs), main antigen presenting orchestrators adaptive response, inducing T B cell...
Abstract Conventional dendritic cells (cDCs) are specialized in antigen presentation. In the mouse spleen, cDCs classified cDC1s and cDC2s, express DEC205 DCIR2 endocytic receptors, respectively. Monoclonal antibodies (mAbs) αDEC205 (αDEC) αDCIR2 have been fused to different antigens deliver them or cDC2s. We immunized mice with αDEC an using Poly(I:C) as adjuvant. The initial immune response was analyzed from days 3 6 after immunization. also studied influence of a booster dose. Our results...