A5053671210- Essential Oils and Antimicrobial Activity
- Neuroscience and Neuropharmacology Research
- Amino Acid Enzymes and Metabolism
- Pancreatic function and diabetes
- Electrospun Nanofibers in Biomedical Applications
- Phytochemistry and Biological Activities
- Space Exploration and Technology
- Tissue Engineering and Regenerative Medicine
- Phytochemical compounds biological activities
- Spaceflight effects on biology
- Genomic variations and chromosomal abnormalities
- Phytochemicals and Medicinal Plants
- Metabolism, Diabetes, and Cancer
- Ethnobotanical and Medicinal Plants Studies
- Genomics and Rare Diseases
- Nitric Oxide and Endothelin Effects
- Natural product bioactivities and synthesis
- GABA and Rice Research
- Phytochemistry and Bioactive Compounds
- Genetics, Aging, and Longevity in Model Organisms
- Tannin, Tannase and Anticancer Activities
- Food Science and Nutritional Studies
- Natural Antidiabetic Agents Studies
- Adipose Tissue and Metabolism
- Polyamine Metabolism and Applications
Uppsala University
2018-2022
Science for Life Laboratory
2022
Centre for Cellular and Molecular Biology
2019-2020
Maharaja Engineering College
2017
Amino acid sensing and signalling is vital for cells, both gene expression protein levels of amino transporters are regulated in response to availability. Here, the aim was study regulation all members SLC38 transporter family, Slc38a1-11, mouse brain cells following starvation. We reanalyzed microarray data immortalized hypothalamic cell line N25/2 subjected complete starvation 1 h, 2 3 5 h or 16 focusing specifically on family. All 11 Slc38 genes were expressed line, Slc38a1, Slc38a2...
Graphical Abstract SLC38A10 role in cells survival under stress.
Glutamate acts as a critical regulator of neurotransmitter balance, recycling, synaptic function and homeostasis in the brain glutamate transporters control levels brain. SLC38A10 is member SLC38 family regulates protein synthesis cellular stress responses. Here, we uncover role transceptor involved glutamate-sensing signaling pathways that both mTOR-signaling. The culture primary cortex cells from knockout mice had increased intracellular glutamate. In addition, under nutrient starvation,...
Abstract Understanding how stem cells adapt to space flight conditions is fundamental for human missions and extraterrestrial settlement. We analyzed gene expression in boundary cap neural crest (BCs), which are attractive regenerative medicine by their ability promote proliferation survival of cocultured co‐implanted cells. BCs were launched (space exposed cells) (SEC), onboard sounding rocket MASER 14 as free‐floating neurospheres or a bioprinted scaffold. For comparison, placed random...
The solute carrier (SLC) family-38 of transporters has eleven members known to transport amino acids, with glutamine being a common substrate for ten them, SLC38A9 the exception. In this study, we examine subcellular localization SNAT10 in several independent immortalized cell lines and stem cell-derived neurons. Co-localization studies confirmed was specifically localized secretory organelles. is expressed both excitatory inhibitory neurons mouse brain, predominantly endoplasmic reticulum,...
Many newly identified SLCs and putative transporters have the possibility to be intricately involved in glucose metabolism. Here we show that many of this type display a high degree regulation at both mRNA protein level following no or low availability mouse cortex cultures. We is also case D. melanogaster subjected starvation diets with different sugar content. Interestingly, re-introduction media, refeeding flies, normalized gene expression number targets, indicating fast highly dynamic...
Understanding how stem cells adapt to space flight conditions is fundamental for human missions and extraterrestrial settlement. We analyzed gene expression in boundary cap neural crest (bNCSCs), which are attractive regenerative medicine by their ability promote proliferation survival of co-cultured co-implanted cells. bNCSCs were launched (Space cells), onboard Sounding rocket as free-floating neurospheres or bioprinted scaffold. For comparison, placed random positioning machine simulate...
Objective: The aim of this study was to examine various extracts leaves Holoptelea integrifolia against some test bacteria and fungi.
 Methods: Disk diffusion method adopted for the assessment antimicrobial activity. Amikacin nystatin were used as standard drugs antibacterial antifungal activity, respectively.
 Results: screening data indicated that all four showed activity Staphylococcus aureus, but growth inhibited most by aqueous extract. In case efficacy, almost fungi....
The aim of this study was to characterize the phytochemicals and investigate antimicrobial efficacy shade dried roots Asparagus adscendens. powder were extracted with chloroform after removal solvent under reduced pressure subjected for chromatographic separation. After column chromatography purification five compounds i.e .hexacosanyltriacontanoate, hexatriacontanone, 2,3,5,7-tetramethoxydi hydrophenanthrene, -sitosterol stigmasterol characterized help physical spectral analysis(IR, 1HNMR,...
The aim of the present study was to investigate phytochemical and antibacterial potential Calendula officinals L. Catharanthus roseus G. Don leaves. leaves both plants were screened for physico-chemical analysis. Phytochemical screening carried out find phytoconstituents subsequent studies extracts against pathogenic bacterial strains Bacillus cereus, subtilis, Escherichia coli, Staphylococcus aureus Salmonella typhi using Kirby bauer method. extract with maximum activity further processed...
The present study deals with pharmacological studies of ethanolic extract roots H. integrifolia (Roxb.) Planch (Family: Ulmaceae) . extracts were examined for antimicrobial by using Disc diffusion method , antiviral efficacy was undertaken plaque inhibition and antineoplastic activity tested Sarcoma 180A 0 as the test system data suggested that root showed pronounced against bacteria viruses. It also exhibited antifungal but failed to demonstrated any antitumor activity.
Objective: The present study deals with the phytochemical and Biological investigation of ethanolic extract aerial parts Abutilon bitentatum Hochst.Methods: Ethanolic A. was chromatographed over a silica gel column for analysis Pharmacological studies includes anti-microbial, anti-viral anti-tumor activity bidentatum.Results: Phytochemical revealed presence n-tetracosane, cetyl stearate, tetracosyl alcohol, cycloartenone, β-amyrin, β-sitisterol, alantolactone, isoalantolactone new cholestane...
Abstract Extracellular matrix of each tissue is unique in composition, architecture and finer details that support the very identity organ by regulating status/character cells within it. Tissue engineering centers around creating a niche similar to natural one, with purpose developing an organ/oid. In this study, whole decellularization pancreas was attempted followed reseeding it adult mesenchymal stem cells. Decellularization completely removes leaving behind extracellular rich scaffold....
Dravet syndrome is an early onset devastating epilepsy usually caused by heterozygous mutations in SCN1A. We generated a human iPSC line (UUIGPi015-A) from dermal fibroblasts of patient with carrying deletion on chromosome 2 encompassing SCN1A and 9 flanking genes. Characterization the confirmed expression pluripotency markers, tri-lineage differentiation capacity absence exogenous reprogramming factors. The retained was genomically stable. UUIGPi015-A provides useful resource for studies...