A5102851601- Neurogenetic and Muscular Disorders Research
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Amino Acid Enzymes and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Neuroscience and Neuropharmacology Research
- Cell Image Analysis Techniques
- Industrial Vision Systems and Defect Detection
- Advanced machining processes and optimization
- Venous Thromboembolism Diagnosis and Management
- Topic Modeling
- Muscle Physiology and Disorders
- Radiation Dose and Imaging
- Cancer-related gene regulation
- Metabolism, Diabetes, and Cancer
- Ultrasound in Clinical Applications
- Animal testing and alternatives
- Drug Transport and Resistance Mechanisms
- Non-Destructive Testing Techniques
- Adrenal Hormones and Disorders
- Soft tissue tumor case studies
- Nitric Oxide and Endothelin Effects
- Cardiac Imaging and Diagnostics
- Advanced Text Analysis Techniques
- bioluminescence and chemiluminescence research
Northeast Georgia Medical Center
2023-2024
Mahatma Gandhi University
2023
Panjab University
2023
Gandhi Medical College & Hospital
2023
University of Iowa
2021-2022
Uppsala University
2017-2022
Science for Life Laboratory
2022
University of Iowa Hospitals and Clinics
2020-2021
Indian Institute of Technology Delhi
2020
Italian Institute of Technology
2013-2015
Polyglutamine expansion in androgen receptor (AR) is responsible for spinobulbar muscular atrophy (SBMA) that leads to selective loss of lower motor neurons. Using SBMA as a model, we explored the relationship between protein structure/function and neurodegeneration polyglutamine diseases. We show here arginine methyltransferase 6 (PRMT6) specific co-activator normal mutant AR interaction PRMT6 with significantly enhanced mutant. occurs through steroid motif, LXXLL, activating function 2...
Amyotrophic lateral sclerosis (ALS) is a late onset and progressive motor neuron disease. Mutations in the gene coding for fused sarcoma/translocated liposarcoma (FUS) are responsible some cases of both familial sporadic forms ALS. The mechanism through which mutations FUS result degeneration loss not known. belongs to family TET proteins, regulated at post-translational level by arginine methylation. Here, we investigated impact methylation pathogenesis FUS-related We found that wild type...
Amyotrophic lateral sclerosis (ALS) is a motoneuron disease characterized by misfolded proteins aggregation in affected motoneurons. In mutant SOD1 (mutSOD1) ALS models, correlates to impaired functions of proteasome and/or autophagy, both essential for the intracellular chaperone-mediated protein quality control (PQC), and reduced mutSOD1 clearance from Skeletal muscle cells are also sensitive toxicity, but no aggregates formed these cells, that might better manage than Thus, we analyzed...
Abstract Spinal and bulbar muscular atrophy (SBMA) is characterized by loss of motoneurons sensory neurons, accompanied muscle cells. SBMA due to an androgen receptor containing a polyglutamine tract (ARpolyQ) that misfolds aggregates, thereby perturbing the protein quality control (PQC) system. Using AR113Q mice we analyzed proteotoxic stress-induced alterations HSPB8-mediated PQC machinery promoting clearance misfolded proteins autophagy. In symptomatic male mice, found expression...
Environmental chemicals are commonly studied one at a time, and there is need to advance our understanding of the effect exposure their combinations. Here we apply high-content microscopy imaging cells stained with multiplexed dyes (Cell Painting) profile effects Cetyltrimethylammonium bromide (CTAB), Bisphenol A (BPA), Dibutyltin dilaurate (DBTDL) on four human cell lines; both individually in all We show that morphological features can be used multivariate data analysis discern between...
Abstract Side experiments are performed on radiomics models to improve their reproducibility. We measure the impact of myocardial masks, radiomic side and data augmentation for information transfer (DAFIT) approach differentiate patients with without pulmonary hypertension (PH) using cardiac MRI (CMRI) derived radiomics. Feature extraction was from left ventricle (LV) right (RV) masks CMRI in 82 (42 PH 40 controls). Various study were evaluated: Original intraclass correlation (ICC)...
Graphical Abstract SLC38A10 role in cells survival under stress.
Glutamate acts as a critical regulator of neurotransmitter balance, recycling, synaptic function and homeostasis in the brain glutamate transporters control levels brain. SLC38A10 is member SLC38 family regulates protein synthesis cellular stress responses. Here, we uncover role transceptor involved glutamate-sensing signaling pathways that both mTOR-signaling. The culture primary cortex cells from knockout mice had increased intracellular glutamate. In addition, under nutrient starvation,...
ALS is a devastating disease resulting in degeneration of motor neurons (MNs) the brain and spinal cord. The survival MNs strongly depends on surrounding glial cells neurotrophic support from muscles. We previously demonstrated that boundary cap neural crest stem (bNCSCs) can give rise to vitro vivo have multiple beneficial effects co-cultured co-implanted cells, including cells. In this paper, we investigate if bNCSCs may improve harboring mutant form human SOD1 (SOD1
The role of reliable, non-invasive imaging-based recognition pulmonary hypertension (PH) remains a diagnostic challenge. aim the current pilot radiomics study was to assess performance cardiac MRI (cMRI)-based texture features accurately predict PH. involved IRB-approved retrospective analysis cMRIs from 72 patients (42 PH and 30 healthy controls) for primary analysis. A subgroup performed including group with left ventricle ejection fraction ≥ 50%. Texture were generated mid-left myocardium...
Solute Carrier (SLC) is a cluster of families membrane bound transporters, which many members lack defined substrate profile, and more are poorly characterized. Many play vital role in regulating metabolic systems, protein synthesis post translational modifications. SLC38 one the SLCs, also known as sodium-coupled neutral amino acid transporters (SNATs). In mice, it has 11 (SNAT1-11) but Drosophila there two homologues for family; CG13743 CG30394. Here, we show characteristics closely...
The number of transporter proteins that are not fully characterized is immense. Here, we used Drosophila melanogaster and human cell lines to perform a first in-depth characterization CG4928, an ortholog the UNC93A, which little known. Solute carriers regulate maintain biochemical pathways important for body, malfunctioning transport associated with multiple diseases. Based on phylogenetic analysis, CG4928 closely related UNC93A has secondary tertiary protein structure folding similar major...
Presented hereunder is probably the first reported case of endometriosis at vaginal apex following hysterectomy. No other similar could be traced in review literature.
Leclercia adecarboxylata is a Gram-negative bacillus commonly seen in immunocompromised individuals and often misdiagnosed as Escherichia coli. L. an opportunistic pathogen found aquatic environments. It nonfatal infection that has low virulence endorses susceptibility to many common antibiotics. We report case of 53-year-old male who was managed for bacteremia.